hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02241.1

Confidence: Extremely High

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Genename	Protein Name	Uniprot Annotation Score	Links
IDS	Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain]	5	UniProt NCBI
PCSK9	Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9)	5	UniProt NCBI
PPIB	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)	5	UniProt NCBI

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP2846	0.00908670029654	1.0	PCSK9	PCSK9 mediated LDL receptor degradation
WP:WP3408	0.00908670029654	1.0	PCSK9	Evolocumab mechanism to reduce LDL cholesterol

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Protein 1	Protein 2	Score	ProteomeHD	Evidence
PPIB	IDS	0.975	0.196	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
IDS	PCSK9	0.952	0.134	bioplex3_WMM bioplex3_HCT116 WMM_only
PPIB	PCSK9	0.06	0.102	bioplex3_HEK293 bioplex3_WMM WMM_only

Showing 1 to 3 of 3 entries

Related Complexes

Genename	Complexes
PPIB	huMAP3_00018.1 huMAP3_02241.1 huMAP3_04471.1 huMAP3_04483.1 huMAP3_04766.1 huMAP3_05492.1 huMAP3_07528.1 huMAP3_08741.1 huMAP3_09054.1 huMAP3_10032.1 huMAP3_10056.1 huMAP3_10782.1 huMAP3_12287.1 huMAP3_12688.1 huMAP3_13862.1 huMAP3_14866.1
IDS	huMAP3_02241.1 huMAP3_07528.1 huMAP3_08741.1 huMAP3_09327.1 huMAP3_10485.1
PCSK9	huMAP3_02241.1 huMAP3_04426.1 huMAP3_04698.1 huMAP3_07112.1 huMAP3_07528.1 huMAP3_08571.1 huMAP3_08741.1 huMAP3_08802.1 huMAP3_09327.1 huMAP3_09675.1 huMAP3_09956.1