hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02241.1
Complex Portal: CPX-23149
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PPIB | Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) | 5 | UniProt NCBI |
| IDS | Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain] | 5 | UniProt NCBI |
| PCSK9 | Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2846 | 0.00908670029654 | 1.0 | PCSK9 | PCSK9 mediated LDL receptor degradation |
| WP:WP3408 | 0.00908670029654 | 1.0 | PCSK9 | Evolocumab mechanism to reduce LDL cholesterol |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PPIB | IDS | 0.975 | 0.196 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IDS | PCSK9 | 0.952 | 0.134 |
structurally_consistent (dimer)
|
bioplex3_WMM bioplex3_HCT116 WMM_only |
| PPIB | PCSK9 | 0.06 | 0.102 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes