hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02242.1

Complex Portal: CPX-15219

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
AHSG	Alpha-2-HS-glycoprotein (Alpha-2-Z-globulin) (Ba-alpha-2-glycoprotein) (Fetuin-A) [Cleaved into: Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B]	5	UniProt NCBI
C4A	Complement C4-A (Acidic complement C4) (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2) [Cleaved into: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain]	5	UniProt NCBI
FGG	Fibrinogen gamma chain	5	UniProt NCBI
ORM1	Alpha-1-acid glycoprotein 1 (AGP 1) (Orosomucoid-1) (OMD 1)	5	UniProt NCBI
C3	Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]	5	UniProt NCBI
APOA4	Apolipoprotein A-IV (Apo-AIV) (ApoA-IV) (Apolipoprotein A4)	5	UniProt NCBI
FGA	Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]	5	UniProt NCBI
SERPINA3	Alpha-1-antichymotrypsin (ACT) (Cell growth-inhibiting gene 24/25 protein) (Serpin A3) [Cleaved into: Alpha-1-antichymotrypsin His-Pro-less]	5	UniProt NCBI
TF	Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0072562	1.13730532079e-15	1.0	APOA4 C3 FGA C4A FGG TF SERPINA3 ORM1 AHSG	blood microparticle
REAC:R-HSA-8957275	7.3286024579e-10	0.666666666667	C3 FGA C4A FGG TF AHSG	Post-translational protein phosphorylation
REAC:R-HSA-381426	1.72600644838e-09	0.666666666667	C3 FGA C4A FGG TF AHSG	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
REAC:R-HSA-114608	2.3281537443e-09	0.666666666667	SERPINA3 FGA FGG ORM1 TF AHSG	Platelet degranulation
REAC:R-HSA-76005	3.09576293776e-09	0.666666666667	SERPINA3 FGA FGG ORM1 TF AHSG	Response to elevated platelet cytosolic Ca2+
REAC:R-HSA-76002	1.91811224112e-07	0.666666666667	SERPINA3 FGA FGG ORM1 TF AHSG	Platelet activation, signaling and aggregation
GO:0005788	6.32929651398e-07	0.777777777778	APOA4 C3 FGA C4A FGG TF AHSG	endoplasmic reticulum lumen
GO:0034774	1.91424416232e-06	0.777777777778	SERPINA3 FGA FGG TF ORM1 C3 AHSG	secretory granule lumen
GO:0060205	2.00945238543e-06	0.777777777778	SERPINA3 FGA FGG TF ORM1 C3 AHSG	cytoplasmic vesicle lumen
GO:0031983	2.05855651849e-06	0.777777777778	SERPINA3 FGA FGG TF ORM1 C3 AHSG	vesicle lumen
KEGG:04610	3.19788320085e-06	0.444444444444	FGA FGG C4A C3	Complement and coagulation cascades
GO:0031093	4.28357878785e-06	0.555555555556	FGA FGG SERPINA3 AHSG ORM1	platelet alpha granule lumen
WP:WP2806	8.02500853475e-06	0.444444444444	FGA FGG C4A C3	Complement system
GO:0031091	1.92708556818e-05	0.555555555556	FGA FGG SERPINA3 AHSG ORM1	platelet alpha granule
REAC:R-HSA-168249	2.28848309051e-05	0.777777777778	C3 FGA C4A FGG SERPINA3 ORM1 AHSG	Innate Immune System
REAC:R-HSA-109582	3.79190436273e-05	0.666666666667	SERPINA3 FGA FGG ORM1 TF AHSG	Hemostasis
CORUM:6417	8.20609246787e-05	0.222222222222	FGG FGA	Fibrinogen complex
KEGG:05150	0.000167515848143	0.333333333333	FGG C4A C3	Staphylococcus aureus infection
KEGG:05171	0.00021375047254	0.444444444444	FGA FGG C4A C3	Coronavirus disease - COVID-19
GO:0062023	0.000289590581476	0.666666666667	APOA4 SERPINA3 FGA FGG ORM1 AHSG	collagen-containing extracellular matrix
GO:0070062	0.000373674637146	1.0	APOA4 C3 FGA C4A FGG TF SERPINA3 ORM1 AHSG	extracellular exosome
WP:WP176	0.000380392295535	0.333333333333	FGG SERPINA3 FGA	Folate metabolism
GO:1903561	0.000406158005187	1.0	APOA4 C3 FGA C4A FGG TF SERPINA3 ORM1 AHSG	extracellular vesicle
GO:0043230	0.000408144647603	1.0	APOA4 C3 FGA C4A FGG TF SERPINA3 ORM1 AHSG	extracellular organelle
GO:0065010	0.000408144647603	1.0	APOA4 C3 FGA C4A FGG TF SERPINA3 ORM1 AHSG	extracellular membrane-bounded organelle
WP:WP4927	0.000460776596117	0.222222222222	FGG FGA	COVID 19 thrombosis and anticoagulation
GO:0030141	0.000555284428772	0.777777777778	SERPINA3 FGA FGG TF ORM1 C3 AHSG	secretory granule
WP:WP15	0.000723743379875	0.333333333333	FGG SERPINA3 FGA	Selenium micronutrient network
GO:0060627	0.000845655443194	0.666666666667	C3 FGA C4A FGG TF AHSG	regulation of vesicle-mediated transport
HP:0400008	0.000919082356402	0.222222222222	FGG FGA	Menometrorrhagia
HP:0034287	0.000919082356402	0.222222222222	FGG FGA	Afibrinogenemia
GO:0031012	0.000980122410403	0.666666666667	APOA4 SERPINA3 FGA FGG ORM1 AHSG	extracellular matrix
GO:0030312	0.000980122410403	0.666666666667	APOA4 SERPINA3 FGA FGG ORM1 AHSG	external encapsulating structure
GO:0099503	0.00145860766152	0.777777777778	SERPINA3 FGA FGG TF ORM1 C3 AHSG	secretory vesicle
REAC:R-HSA-174577	0.00167485737707	0.222222222222	C3 C4A	Activation of C3 and C5
REAC:R-HSA-168256	0.00186369688073	0.777777777778	C3 FGA C4A FGG SERPINA3 ORM1 AHSG	Immune System
REAC:R-HSA-392499	0.00202692701529	0.777777777778	APOA4 C3 FGA C4A FGG TF AHSG	Metabolism of proteins
HP:0100310	0.00306165140522	0.222222222222	FGG FGA	Epidural hemorrhage
HP:0012223	0.00306165140522	0.222222222222	FGG FGA	Splenic rupture
WP:WP545	0.00416305404355	0.222222222222	C3 C4A	Complement activation
KEGG:04613	0.00421630879124	0.333333333333	FGG FGA C3	Neutrophil extracellular trap formation
REAC:R-HSA-354194	0.00438093013445	0.222222222222	FGG FGA	GRB2:SOS provides linkage to MAPK signaling for Integrins
WP:WP272	0.00468193988771	0.222222222222	FGG FGA	Blood clotting cascade
REAC:R-HSA-372708	0.00525543712779	0.222222222222	FGG FGA	p130Cas linkage to MAPK signaling for integrins
REAC:R-HSA-597592	0.00564787922656	0.666666666667	C3 FGA C4A FGG TF AHSG	Post-translational protein modification
HP:0004936	0.00600237677255	0.333333333333	FGG C4A FGA	Venous thrombosis
HP:0011884	0.0064253619375	0.222222222222	FGG FGA	Abnormal umbilical stump bleeding
REAC:R-HSA-5602498	0.00724150508664	0.222222222222	FGG FGA	MyD88 deficiency (TLR2/4)
REAC:R-HSA-5603041	0.00724150508664	0.222222222222	FGG FGA	IRAK4 deficiency (TLR2/4)
GO:0005615	0.00730177587354	1.0	APOA4 C3 FGA C4A FGG TF SERPINA3 ORM1 AHSG	extracellular space
REAC:R-HSA-5686938	0.00835291407054	0.222222222222	FGG FGA	Regulation of TLR by endogenous ligand
GO:0051050	0.00875194794696	0.666666666667	C3 FGA C4A FGG TF AHSG	positive regulation of transport
REAC:R-HSA-166663	0.00954313848115	0.222222222222	C3 C4A	Initial triggering of complement
REAC:R-HSA-140875	0.0108121024449	0.222222222222	FGG FGA	Common Pathway of Fibrin Clot Formation
GO:0031410	0.0109403276913	0.888888888889	APOA4 C3 FGA FGG TF SERPINA3 ORM1 AHSG	cytoplasmic vesicle
HP:0030137	0.0110078716337	0.222222222222	FGG FGA	Prolonged bleeding following circumcision
GO:0097708	0.0110977854262	0.888888888889	APOA4 C3 FGA FGG TF SERPINA3 ORM1 AHSG	intracellular vesicle
WP:WP5115	0.0114539669178	0.333333333333	FGG TF FGA	Network map of SARS CoV 2 signaling pathway
GO:0051049	0.0132611155138	0.777777777778	APOA4 C3 FGA C4A FGG TF AHSG	regulation of transport
WP:WP4136	0.016080037976	0.222222222222	FGG FGA	Fibrin complement receptor 3 signaling pathway
GO:0045807	0.0166325722167	0.444444444444	TF C3 AHSG C4A	positive regulation of endocytosis
REAC:R-HSA-354192	0.0166738379974	0.222222222222	FGG FGA	Integrin signaling
GO:0005576	0.0175413137939	1.0	APOA4 C3 FGA C4A FGG TF SERPINA3 ORM1 AHSG	extracellular region
REAC:R-HSA-6798695	0.0194423778228	0.444444444444	ORM1 SERPINA3 AHSG C3	Neutrophil degranulation
HP:0100309	0.0201617678902	0.222222222222	FGG FGA	Subdural hemorrhage
HP:0001934	0.0201617678902	0.222222222222	FGG FGA	Persistent bleeding after trauma
REAC:R-HSA-5260271	0.0278157587689	0.222222222222	FGG FGA	Diseases of Immune System
REAC:R-HSA-5602358	0.0278157587689	0.222222222222	FGG FGA	Diseases associated with the TLR signaling cascade
KEGG:05133	0.0286338067835	0.222222222222	C3 C4A	Pertussis
REAC:R-HSA-76009	0.0299458635385	0.222222222222	FGG FGA	Platelet Aggregation (Plug Formation)
GO:0031982	0.0299859493569	1.0	APOA4 C3 FGA C4A FGG TF SERPINA3 ORM1 AHSG	vesicle
HP:0006298	0.0320448157979	0.222222222222	FGG FGA	Prolonged bleeding after dental extraction
REAC:R-HSA-6802948	0.0344394959621	0.222222222222	FGG FGA	Signaling by high-kinase activity BRAF mutants
WP:WP5218	0.0356319901131	0.222222222222	C3 C4A	Extrafollicular and follicular B cell activation by SARS CoV 2
HP:0002248	0.0366109494459	0.222222222222	FGG FGA	Hematemesis
REAC:R-HSA-140877	0.0368028731299	0.222222222222	FGG FGA	Formation of Fibrin Clot (Clotting Cascade)
REAC:R-HSA-5674135	0.0443583465173	0.222222222222	FGG FGA	MAP2K and MAPK activation
REAC:R-HSA-9656223	0.0470317013402	0.222222222222	FGG FGA	Signaling by RAF1 mutants
WP:WP5356	0.0482342246392	0.222222222222	FGG FGA	Affected pathways in Duchenne muscular dystrophy

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
FGG	C3	0.986	0.512		bioplex_WMM bioplex3_WMM WMM_only boldt_WMM treiber_WMM
AHSG	ORM1	0.984	0.282	mutually_exclusive (O43240)	bioplex_WMM bioplex3_WMM WMM_only
ORM1	SERPINA3	0.982	0.77		bioplex_WMM bioplex3_WMM WMM_only
FGA	TF	0.982	0.306		bioplex_WMM bioplex3_WMM WMM_only boldt_WMM
AHSG	FGG	0.981	0.188		bioplex_WMM bioplex3_WMM WMM_only
C3	TF	0.979	0.49		bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM treiber_WMM WMM_only
FGG	FGA	0.979	0.364	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM WMM_only boldt_WMM treiber_WMM
AHSG	C3	0.978	0.394		bioplex_WMM bioplex3_WMM WMM_only
APOA4	C3	0.977	0.296		bioplex_WMM bioplex3_WMM WMM_only
ORM1	APOA4	0.977	0.406		bioplex_WMM bioplex3_WMM WMM_only
AHSG	APOA4	0.977	0.138	structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM WMM_only
FGG	TF	0.976	0.388		bioplex_WMM bioplex3_WMM WMM_only boldt_WMM treiber_WMM
C3	FGA	0.972	0.428		bioplex_WMM bioplex3_WMM WMM_only boldt_WMM treiber_WMM
ORM1	TF	0.972	0.374		bioplex_WMM bioplex3_WMM WMM_only
C3	SERPINA3	0.971	0.366		bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM
APOA4	TF	0.971	0.244		bioplex_WMM bioplex3_WMM WMM_only
AHSG	SERPINA3	0.967	0.276		bioplex_WMM bioplex3_WMM WMM_only
ORM1	C3	0.966	0.676		bioplex_WMM bioplex3_WMM WMM_only
C4A	ORM1	0.966	0.492		bioplex_WMM bioplex3_WMM WMM_only
C4A	C3	0.961	0.474		bioplex_WMM bioplex3_WMM WMM_only treiber_WMM
ORM1	FGA	0.958	0.586		bioplex_WMM bioplex3_WMM WMM_only
ORM1	FGG	0.956	0.642		bioplex_WMM bioplex3_WMM WMM_only
SERPINA3	TF	0.953	0.364		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
C4A	TF	0.949	0.458		bioplex_WMM bioplex3_WMM WMM_only
AHSG	C4A	0.946	0.31		bioplex_WMM bioplex3_WMM WMM_only
AHSG	TF	0.944	0.412		bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only
APOA4	SERPINA3	0.936	0.416		bioplex_WMM bioplex3_WMM WMM_only
C4A	SERPINA3	0.933	0.218		bioplex_WMM bioplex3_WMM WMM_only
FGA	SERPINA3	0.93	0.3		bioplex_WMM bioplex3_WMM WMM_only treiber_WMM
APOA4	FGA	0.891	0.378		bioplex_WMM bioplex3_WMM WMM_only
APOA4	FGG	0.888	0.376		bioplex_WMM bioplex3_WMM WMM_only
FGG	SERPINA3	0.877	0.342		bioplex_WMM bioplex3_WMM WMM_only treiber_WMM
AHSG	FGA	0.765	0.15		bioplex_WMM bioplex3_WMM WMM_only
C4A	FGG	0.669	0.358		bioplex_WMM bioplex3_WMM WMM_only
C4A	FGA	0.637	0.252		bioplex_WMM bioplex3_WMM WMM_only
C4A	APOA4	0.617	0.46		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
AHSG	huMAP3_00484.1 huMAP3_02242.1 huMAP3_07265.1 huMAP3_07432.1 huMAP3_08395.1 huMAP3_08700.1 huMAP3_09434.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1
C4A	huMAP3_00484.1 huMAP3_02242.1 huMAP3_07265.1 huMAP3_07432.1 huMAP3_07603.1 huMAP3_08395.1 huMAP3_08450.1 huMAP3_08700.1 huMAP3_09273.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10426.1 huMAP3_10678.1 huMAP3_11174.1 huMAP3_15040.1
FGG	huMAP3_02242.1 huMAP3_07541.1 huMAP3_08224.1 huMAP3_08395.1 huMAP3_09434.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1
ORM1	huMAP3_00484.1 huMAP3_02242.1 huMAP3_07265.1 huMAP3_07432.1 huMAP3_08395.1 huMAP3_08700.1 huMAP3_09434.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1
C3	huMAP3_02242.1 huMAP3_07432.1 huMAP3_08224.1 huMAP3_08395.1 huMAP3_09434.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1
APOA4	huMAP3_00484.1 huMAP3_02242.1 huMAP3_07265.1 huMAP3_07432.1 huMAP3_08395.1 huMAP3_08700.1 huMAP3_09434.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1
FGA	huMAP3_02242.1 huMAP3_06675.1 huMAP3_07432.1 huMAP3_08224.1 huMAP3_08395.1 huMAP3_09434.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1
SERPINA3	huMAP3_02242.1 huMAP3_07265.1 huMAP3_07432.1 huMAP3_08224.1 huMAP3_08395.1 huMAP3_09434.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1
TF	huMAP3_02242.1 huMAP3_07265.1 huMAP3_07432.1 huMAP3_08224.1 huMAP3_08395.1 huMAP3_09434.1 huMAP3_09531.1 huMAP3_10101.1 huMAP3_10678.1 huMAP3_15040.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_02242.1

Complex Portal: CPX-15219