hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02247.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PRMT5 | Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed] | 5 | UniProt NCBI |
| RIOK1 | Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1) | 5 | UniProt NCBI |
| CIRBP | Cold-inducible RNA-binding protein (A18 hnRNP) (Glycine-rich RNA-binding protein CIRP) | 5 | UniProt NCBI |
| WDR77 | Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2838 | 1.53774525569e-05 | 0.5 | PRMT5 WDR77 | MEP50-PRMT5-ICLN complex |
| CORUM:837 | 1.53774525569e-05 | 0.5 | PRMT5 WDR77 | MEP50-PRMT5-ICLN complex |
| CORUM:6858 | 5.12488211613e-05 | 0.5 | PRMT5 WDR77 | CHTOP-methylosome complex |
| CORUM:811 | 0.000107602882996 | 0.5 | PRMT5 WDR77 | FCP1-associated protein complex |
| CORUM:810 | 0.000107602882996 | 0.5 | PRMT5 WDR77 | FCP1-associated protein complex |
| GO:0048026 | 0.000372255315939 | 0.75 | PRMT5 CIRBP WDR77 | positive regulation of mRNA splicing, via spliceosome |
| GO:0050685 | 0.000777349058504 | 0.75 | PRMT5 CIRBP WDR77 | positive regulation of mRNA processing |
| GO:0033120 | 0.00155882617412 | 0.75 | PRMT5 CIRBP WDR77 | positive regulation of RNA splicing |
| REAC:R-HSA-194441 | 0.0130136556072 | 0.5 | PRMT5 WDR77 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 0.0130136556072 | 0.5 | PRMT5 WDR77 | snRNP Assembly |
| REAC:R-HSA-3214858 | 0.0239057396727 | 0.5 | PRMT5 WDR77 | RMTs methylate histone arginines |
| CORUM:2764 | 0.0249718442456 | 0.25 | PRMT5 | PRMT5 complex |
| CORUM:1748 | 0.0249718442456 | 0.25 | PRMT5 | PRMT5 complex |
| GO:0048024 | 0.0364824972322 | 0.75 | PRMT5 CIRBP WDR77 | regulation of mRNA splicing, via spliceosome |
| GO:0034708 | 0.0464975978221 | 0.75 | PRMT5 RIOK1 WDR77 | methyltransferase complex |
| CORUM:825 | 0.049938562206 | 0.25 | PRMT5 | JBP1-pICln complex |
| CORUM:6853 | 0.049938562206 | 0.25 | PRMT5 | COPRS-PRMT5 complex |
| CORUM:836 | 0.049938562206 | 0.25 | PRMT5 | 20S methyltransferase core complex |
| CORUM:7410 | 0.049938562206 | 0.25 | PRMT5 | CAPG-PRMT5 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PRMT5 | WDR77 | 0.999 | 0.914 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| PRMT5 | RIOK1 | 0.994 | 0.214 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM |
| RIOK1 | WDR77 | 0.994 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| CIRBP | WDR77 | 0.993 | 0.022 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CIRBP | PRMT5 | 0.971 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| CIRBP | RIOK1 | 0.963 | 0.03 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
Related Complexes