hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02261.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CACNA2D1 | Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1] | 5 | UniProt NCBI |
| ITGAV | Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] | 5 | UniProt NCBI |
| MFGE8 | Lactadherin (Breast epithelial antigen BA46) (HMFG) (MFGM) (Milk fat globule-EGF factor 8) (MFG-E8) (SED1) [Cleaved into: Lactadherin short form; Medin] | 5 | UniProt NCBI |
| ITGB5 | Integrin beta-5 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2350 | 5.12628525639e-06 | 0.5 | ITGAV ITGB5 | ITGAV-ITGB5 complex |
| CORUM:2347 | 5.12628525639e-06 | 0.5 | ITGAV ITGB5 | ITGAV-ITGB5-SPP1 complex |
| WP:WP2118 | 1.13301263399e-05 | 0.75 | ITGAV CACNA2D1 ITGB5 | Arrhythmogenic right ventricular cardiomyopathy |
| CORUM:2345 | 1.53774525569e-05 | 0.5 | ITGAV ITGB5 | ITGAV-ITGB5-ICAM4 complex |
| CORUM:2346 | 1.53774525569e-05 | 0.5 | ITGAV ITGB5 | ITGAV-ITGB5-ADAM9 complex |
| CORUM:2348 | 1.53774525569e-05 | 0.5 | ITGAV ITGB5 | ITGAV-ITGB5-CYR61 complex |
| CORUM:2343 | 1.53774525569e-05 | 0.5 | ITGAV ITGB5 | ITGAV-ITGB5-PLAUR complex |
| CORUM:3117 | 1.53774525569e-05 | 0.5 | ITGAV ITGB5 | ITGB5-ITGAV-VTN complex |
| KEGG:05412 | 1.71467161414e-05 | 0.75 | ITGAV CACNA2D1 ITGB5 | Arrhythmogenic right ventricular cardiomyopathy |
| KEGG:05410 | 2.40425716137e-05 | 0.75 | ITGAV CACNA2D1 ITGB5 | Hypertrophic cardiomyopathy |
| KEGG:05414 | 2.40425716137e-05 | 0.75 | ITGAV CACNA2D1 ITGB5 | Dilated cardiomyopathy |
| KEGG:04148 | 0.000105799991328 | 0.75 | ITGAV ITGB5 MFGE8 | Efferocytosis |
| REAC:R-HSA-1236973 | 0.000215205765992 | 0.5 | ITGAV ITGB5 | Cross-presentation of particulate exogenous antigens (phagosomes) |
| REAC:R-HSA-3000170 | 0.00236402400204 | 0.5 | ITGAV ITGB5 | Syndecan interactions |
| GO:0034684 | 0.0028092043205 | 0.5 | ITGAV ITGB5 | integrin alphav-beta5 complex |
| WP:WP3888 | 0.00315915016761 | 0.75 | ITGAV CACNA2D1 ITGB5 | VEGFA VEGFR2 signaling |
| REAC:R-HSA-2129379 | 0.00415229579539 | 0.5 | ITGAV ITGB5 | Molecules associated with elastic fibres |
| KEGG:04512 | 0.00551283411821 | 0.5 | ITGAV ITGB5 | ECM-receptor interaction |
| REAC:R-HSA-1566948 | 0.00643909852192 | 0.5 | ITGAV ITGB5 | Elastic fibre formation |
| REAC:R-HSA-2173789 | 0.00837722051003 | 0.5 | ITGAV ITGB5 | TGF-beta receptor signaling activates SMADs |
| WP:WP185 | 0.00883615359641 | 0.5 | ITGAV ITGB5 | Integrin mediated cell adhesion |
| WP:WP5090 | 0.00992155513194 | 0.5 | ITGAV MFGE8 | Complement system in neuronal development and plasticity |
| REAC:R-HSA-3000171 | 0.0115164156767 | 0.5 | ITGAV ITGB5 | Non-integrin membrane-ECM interactions |
| WP:WP4541 | 0.011545786253 | 0.5 | ITGAV ITGB5 | Hippo Merlin signaling dysregulation |
| WP:WP4217 | 0.0168573248614 | 0.5 | ITGAV MFGE8 | Ebola virus infection in host |
| REAC:R-HSA-3000178 | 0.0168610262513 | 0.5 | ITGAV ITGB5 | ECM proteoglycans |
| REAC:R-HSA-216083 | 0.0199119958937 | 0.5 | ITGAV ITGB5 | Integrin cell surface interactions |
| KEGG:04145 | 0.0214296747035 | 0.5 | ITGAV ITGB5 | Phagosome |
| CORUM:2846 | 0.0249718442456 | 0.25 | ITGAV | ITGAV-ITGB3-THBS1 complex |
| CORUM:2352 | 0.0249718442456 | 0.25 | ITGAV | ITGAV-ITGB6-SPP1 complex |
| CORUM:2353 | 0.0249718442456 | 0.25 | ITGAV | ITGAV-ITGB6-TGFB3 complex |
| CORUM:2354 | 0.0249718442456 | 0.25 | ITGAV | ITGAV-ITGB6 complex |
| CORUM:2358 | 0.0249718442456 | 0.25 | ITGAV | ITGAV-ITGB3-SPP1 complex |
| CORUM:2816 | 0.0249718442456 | 0.25 | ITGAV | ITGAV-ITGB3 complex |
| CORUM:2849 | 0.0249718442456 | 0.25 | ITGAV | ITGAV-ITGB3-NOV complex |
| CORUM:2373 | 0.0249718442456 | 0.25 | ITGAV | ITGAV-ITGB3-SPP1 complex |
| CORUM:2365 | 0.0249718442456 | 0.25 | ITGAV | ITGAV-ITGB3-COL4A3 complex |
| KEGG:04510 | 0.03673756538 | 0.5 | ITGAV ITGB5 | Focal adhesion |
| WP:WP306 | 0.0374055211141 | 0.5 | ITGAV ITGB5 | Focal adhesion |
| REAC:R-HSA-170834 | 0.0380580405855 | 0.5 | ITGAV ITGB5 | Signaling by TGF-beta Receptor Complex |
| KEGG:05205 | 0.0406374666322 | 0.5 | ITGAV ITGB5 | Proteoglycans in cancer |
| KEGG:04810 | 0.0466115978004 | 0.5 | ITGAV ITGB5 | Regulation of actin cytoskeleton |
| REAC:R-HSA-1236975 | 0.0483046623758 | 0.5 | ITGAV ITGB5 | Antigen processing-Cross presentation |
| CORUM:6993 | 0.049938562206 | 0.25 | ITGAV | FGF1-ITGAV-ITGB3 complex |
| CORUM:6193 | 0.049938562206 | 0.25 | ITGAV | ADAM12-alphaVbeta3-integrin-MMP-14 complex |
| CORUM:5712 | 0.049938562206 | 0.25 | ITGB5 | FAK-beta5 integrin complex, VEGF induced |
| CORUM:7356 | 0.049938562206 | 0.25 | MFGE8 | IL-15-lactadherin complex |
| CORUM:2374 | 0.049938562206 | 0.25 | ITGAV | ITGAV-ITGB3-LAMA4 complex |
| CORUM:2885 | 0.049938562206 | 0.25 | ITGAV | ITGAV-ITGB1-SPP1 complex |
| CORUM:2826 | 0.049938562206 | 0.25 | ITGAV | ITGB3-ITGAV-VTN complex |
| CORUM:2436 | 0.049938562206 | 0.25 | ITGAV | ITGAV-ITGB1 complex |
| CORUM:2369 | 0.049938562206 | 0.25 | ITGAV | ITGAV-ITGB3-EGFR complex |
| CORUM:2366 | 0.049938562206 | 0.25 | ITGAV | ITGAV-ITGB3-PPAP2b complex |
| CORUM:2364 | 0.049938562206 | 0.25 | ITGAV | ITGAV-ITGB3-ADAM23 complex |
| CORUM:2363 | 0.049938562206 | 0.25 | ITGAV | ITGAV-ITGB3-PXN-PTK2b complex |
| CORUM:2362 | 0.049938562206 | 0.25 | ITGAV | ITAGV-ITGB3-F11R complex |
| CORUM:2359 | 0.049938562206 | 0.25 | ITGAV | ITGAV-ITGB3-ADAM15 complex |
| CORUM:2356 | 0.049938562206 | 0.25 | ITGAV | ITGB3-ITGAV-CD47 complex |
| CORUM:3103 | 0.049938562206 | 0.25 | ITGAV | ITGAV-ITGB3-SLC3A2 complex |
| CORUM:2355 | 0.049938562206 | 0.25 | ITGAV | ITGAV-ITGB3-CD47-FCER2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MFGE8 | ITGB5 | 0.992 | 0.176 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ITGAV | MFGE8 | 0.986 | 0.156 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CACNA2D1 | ITGAV | 0.973 | 0.074 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ITGAV | ITGB5 | 0.963 | 0.236 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CACNA2D1 | MFGE8 | 0.87 | 0.256 | bioplex_WMM bioplex3_WMM WMM_only |
| CACNA2D1 | ITGB5 | 0.151 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| CACNA2D1 | huMAP3_02261.1 huMAP3_05262.1 huMAP3_05532.1 huMAP3_08957.1 huMAP3_09956.1 huMAP3_12928.1 huMAP3_14107.1 |
| ITGAV | huMAP3_02261.1 huMAP3_09956.1 |
| MFGE8 | huMAP3_02261.1 huMAP3_09327.1 huMAP3_09956.1 |
| ITGB5 | huMAP3_02261.1 huMAP3_04904.1 huMAP3_07112.1 huMAP3_09956.1 huMAP3_10065.1 |