hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02277.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NEK1 | Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (Never in mitosis A-related kinase 1) (NimA-related protein kinase 1) (Renal carcinoma antigen NY-REN-55) | 5 | UniProt NCBI |
| TEKT4 | Tektin-4 | 5 | UniProt NCBI |
| CFAP410 | Cilia- and flagella-associated protein 410 (C21orf-HUMF09G8.5) (Leucine-rich repeat-containing protein 76) (YF5/A2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5234 | 0.00321742070882 | 0.666666666667 | CFAP410 NEK1 | Bardet Biedl syndrome |
| HP:0009067 | 0.00667190161012 | 0.666666666667 | CFAP410 NEK1 | Progressive spinal muscular atrophy |
| HP:0008955 | 0.0075178385046 | 0.666666666667 | CFAP410 NEK1 | Progressive distal muscular atrophy |
| HP:0033683 | 0.00888120343534 | 0.666666666667 | CFAP410 NEK1 | Jaw hyperreflexia |
| HP:0025425 | 0.00888120343534 | 0.666666666667 | CFAP410 NEK1 | Laryngospasm |
| HP:0030195 | 0.00985306624309 | 0.666666666667 | CFAP410 NEK1 | Fatigable weakness of swallowing muscles |
| HP:0012473 | 0.0119478163599 | 0.666666666667 | CFAP410 NEK1 | Tongue atrophy |
| HP:0025424 | 0.0119478163599 | 0.666666666667 | CFAP410 NEK1 | Abnormal larynx physiology |
| HP:0007354 | 0.0130706759587 | 0.666666666667 | CFAP410 NEK1 | Amyotrophic lateral sclerosis |
| WP:WP4803 | 0.0135986549013 | 0.666666666667 | CFAP410 NEK1 | Ciliopathies |
| HP:0002145 | 0.0142438401108 | 0.666666666667 | CFAP410 NEK1 | Frontotemporal dementia |
| HP:0000217 | 0.0154672949612 | 0.666666666667 | CFAP410 NEK1 | Xerostomia |
| HP:0007269 | 0.0154672949612 | 0.666666666667 | CFAP410 NEK1 | Spinal muscular atrophy |
| HP:0030196 | 0.0173967419879 | 0.666666666667 | CFAP410 NEK1 | Fatigable weakness of respiratory muscles |
| HP:0030192 | 0.0201452261528 | 0.666666666667 | CFAP410 NEK1 | Fatigable weakness of bulbar muscles |
| HP:0007373 | 0.022338444757 | 0.666666666667 | CFAP410 NEK1 | Motor neuron atrophy |
| HPA:0210862 | 0.0302328294218 | 0.666666666667 | CFAP410 TEKT4 | fallopian tube; ciliated cells (cilia axoneme)[>=Medium] |
| HP:0002450 | 0.0313463863633 | 0.666666666667 | CFAP410 NEK1 | Abnormal motor neuron morphology |
| HPA:0210861 | 0.0333626298265 | 0.666666666667 | CFAP410 TEKT4 | fallopian tube; ciliated cells (cilia axoneme)[>=Low] |
| HP:0002180 | 0.0340663843581 | 0.666666666667 | CFAP410 NEK1 | Neurodegeneration |
| HP:0012757 | 0.0359423574679 | 0.666666666667 | CFAP410 NEK1 | Abnormal neuron morphology |
| HP:0004326 | 0.045003983416 | 0.666666666667 | CFAP410 NEK1 | Cachexia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NEK1 | CFAP410 | 1.0 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () gupta_WMM boldt_WMM |
| NEK1 | TEKT4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TEKT4 | CFAP410 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes
| Genename | Complexes |
|---|---|
| NEK1 | huMAP3_02277.1 huMAP3_09035.1 huMAP3_15205.1 |
| TEKT4 | huMAP3_02277.1 huMAP3_09035.1 |
| CFAP410 | huMAP3_02277.1 huMAP3_09035.1 |