hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02285.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase) | 5 | UniProt NCBI |
| BIRC3 | Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1) | 5 | UniProt NCBI |
| BCL10 | B-cell lymphoma/leukemia 10 (B-cell CLL/lymphoma 10) (Bcl-10) (CARD-containing molecule enhancing NF-kappa-B) (CARD-like apoptotic protein) (hCLAP) (CED-3/ICH-1 prodomain homologous E10-like regulator) (CIPER) (Cellular homolog of vCARMEN) (cCARMEN) (Cellular-E10) (c-E10) (Mammalian CARD-containing adapter molecule E10) (mE10) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0012123 | 3.46378526402e-09 | 1.0 | BCL10 MALT1 BIRC3 | Posterior uveitis |
| HP:0012191 | 4.84929936962e-07 | 1.0 | BCL10 MALT1 BIRC3 | B-cell lymphoma |
| HP:0100721 | 1.75267534359e-06 | 1.0 | BCL10 MALT1 BIRC3 | Mediastinal lymphadenopathy |
| CORUM:2053 | 3.41752350426e-06 | 0.666666666667 | MALT1 BCL10 | BCL10-MALT1 complex |
| CORUM:2753 | 3.41752350426e-06 | 0.666666666667 | MALT1 BCL10 | FYB-CARMA1-BCL-10-MALT1 complex |
| CORUM:2752 | 3.41752350426e-06 | 0.666666666667 | MALT1 BCL10 | CARMA1-BCL10-MALT1 complex |
| KEGG:04064 | 4.29196879067e-06 | 1.0 | BCL10 MALT1 BIRC3 | NF-kappa B signaling pathway |
| HP:0012539 | 5.18182275497e-06 | 1.0 | BCL10 MALT1 BIRC3 | Non-Hodgkin lymphoma |
| HP:0000554 | 7.91388338196e-06 | 1.0 | BCL10 MALT1 BIRC3 | Uveitis |
| HP:0045026 | 8.55554960212e-06 | 1.0 | BCL10 MALT1 BIRC3 | Abnormal mediastinum morphology |
| HP:0045027 | 1.4041319514e-05 | 1.0 | BCL10 MALT1 BIRC3 | Abnormality of the thoracic cavity |
| HP:0002113 | 1.49774074816e-05 | 1.0 | BCL10 MALT1 BIRC3 | Pulmonary infiltrates |
| CORUM:2054 | 2.05032700758e-05 | 0.666666666667 | MALT1 BCL10 | CASP8-FADD-MALT1-BCL10 complex |
| CORUM:2055 | 3.41705576683e-05 | 0.666666666667 | MALT1 BCL10 | CASP8-CHUK-IKBKB-MALT1-BCL10 complex |
| CORUM:2745 | 3.41705576683e-05 | 0.666666666667 | MALT1 BCL10 | Ubiquitin E3 ligase (TRAF6, TAB2, MALT1, UEV1A, BCL10) |
| HP:0000614 | 3.607878731e-05 | 1.0 | BCL10 MALT1 BIRC3 | Abnormal nasolacrimal system morphology |
| HP:0002665 | 0.00015769228793 | 1.0 | BCL10 MALT1 BIRC3 | Lymphoma |
| HP:0031983 | 0.000237112554302 | 1.0 | BCL10 MALT1 BIRC3 | Abnormal pulmonary thoracic imaging finding |
| HP:0000975 | 0.000379274961 | 1.0 | BCL10 MALT1 BIRC3 | Hyperhidrosis |
| HP:0100533 | 0.000773463249455 | 1.0 | BCL10 MALT1 BIRC3 | Inflammatory abnormality of the eye |
| HP:0007550 | 0.000989893541945 | 1.0 | BCL10 MALT1 BIRC3 | Hypohidrosis or hyperhidrosis |
| HP:0002716 | 0.00100560613785 | 1.0 | BCL10 MALT1 BIRC3 | Lymphadenopathy |
| HP:0025276 | 0.00110338533207 | 1.0 | BCL10 MALT1 BIRC3 | Abnormality of skin adnexa physiology |
| HP:0002733 | 0.00124334303944 | 1.0 | BCL10 MALT1 BIRC3 | Abnormal lymph node morphology |
| WP:WP3863 | 0.00132925024934 | 0.666666666667 | MALT1 BCL10 | T cell antigen receptor TCR pathway during Staphylococcus aureus infection |
| WP:WP5072 | 0.00155728900053 | 0.666666666667 | MALT1 BCL10 | Modulators of TCR signaling and T cell activation |
| KEGG:04662 | 0.00173372250929 | 0.666666666667 | MALT1 BCL10 | B cell receptor signaling pathway |
| WP:WP69 | 0.00206734131669 | 0.666666666667 | MALT1 BCL10 | T cell receptor signaling pathway |
| HP:0004377 | 0.002595597013 | 1.0 | BCL10 MALT1 BIRC3 | Hematological neoplasm |
| KEGG:04625 | 0.00271491421694 | 0.666666666667 | MALT1 BCL10 | C-type lectin receptor signaling pathway |
| HP:0002027 | 0.00303431918859 | 1.0 | BCL10 MALT1 BIRC3 | Abdominal pain |
| WP:WP5098 | 0.00304949085786 | 0.666666666667 | MALT1 BCL10 | T cell activation SARS CoV 2 |
| WP:WP23 | 0.00321742070882 | 0.666666666667 | MALT1 BCL10 | B cell receptor signaling pathway |
| KEGG:04660 | 0.00399150940056 | 0.666666666667 | MALT1 BCL10 | T cell receptor signaling pathway |
| GO:0032449 | 0.00421361424067 | 0.666666666667 | MALT1 BCL10 | CBM complex |
| HP:0001824 | 0.00481840327101 | 1.0 | BCL10 MALT1 BIRC3 | Weight loss |
| HP:0001945 | 0.00572267550502 | 1.0 | BCL10 MALT1 BIRC3 | Fever |
| HP:0002019 | 0.00742959944095 | 1.0 | BCL10 MALT1 BIRC3 | Constipation |
| KEGG:05152 | 0.00802719593767 | 0.666666666667 | MALT1 BCL10 | Tuberculosis |
| HP:0012378 | 0.00876021081823 | 1.0 | BCL10 MALT1 BIRC3 | Fatigue |
| GO:0031398 | 0.0109157763448 | 1.0 | BCL10 MALT1 BIRC3 | positive regulation of protein ubiquitination |
| HP:0000820 | 0.0122104318992 | 1.0 | BCL10 MALT1 BIRC3 | Abnormality of the thyroid gland |
| HP:0004370 | 0.0123780791059 | 1.0 | BCL10 MALT1 BIRC3 | Abnormality of temperature regulation |
| REAC:R-HSA-1169091 | 0.0141416283812 | 0.666666666667 | MALT1 BCL10 | Activation of NF-kappaB in B cells |
| HP:0002017 | 0.0149841228953 | 1.0 | BCL10 MALT1 BIRC3 | Nausea and vomiting |
| HP:0000553 | 0.0173987795596 | 1.0 | BCL10 MALT1 BIRC3 | Abnormal uvea morphology |
| REAC:R-HSA-1168372 | 0.0183561585619 | 0.666666666667 | MALT1 BCL10 | Downstream signaling events of B Cell Receptor (BCR) |
| REAC:R-HSA-2871837 | 0.0188582038017 | 0.666666666667 | MALT1 BCL10 | FCERI mediated NF-kB activation |
| HP:0001903 | 0.0189203502844 | 1.0 | BCL10 MALT1 BIRC3 | Anemia |
| GO:1903322 | 0.0190783863531 | 1.0 | BCL10 MALT1 BIRC3 | positive regulation of protein modification by small protein conjugation or removal |
| KEGG:05131 | 0.0193802248568 | 0.666666666667 | MALT1 BCL10 | Shigellosis |
| GO:1901875 | 0.019623483106 | 1.0 | BCL10 MALT1 BIRC3 | positive regulation of post-translational protein modification |
| HP:0002205 | 0.0204103893061 | 1.0 | BCL10 MALT1 BIRC3 | Recurrent respiratory infections |
| HP:0001877 | 0.0249404281241 | 1.0 | BCL10 MALT1 BIRC3 | Abnormal erythrocyte morphology |
| CORUM:2051 | 0.0249718442456 | 0.333333333333 | MALT1 | MALT1 homo-oligomer complex |
| CORUM:2052 | 0.0249718442456 | 0.333333333333 | BCL10 | BCL10 homo-oligomer complex |
| REAC:R-HSA-202424 | 0.0265950995478 | 0.666666666667 | MALT1 BCL10 | Downstream TCR signaling |
| REAC:R-HSA-5607764 | 0.0271982878007 | 0.666666666667 | MALT1 BCL10 | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-983705 | 0.0309588280961 | 0.666666666667 | MALT1 BCL10 | Signaling by the B Cell Receptor (BCR) |
| HP:0100763 | 0.0347303971889 | 1.0 | BCL10 MALT1 BIRC3 | Abnormality of the lymphatic system |
| REAC:R-HSA-202403 | 0.0377646799279 | 0.666666666667 | MALT1 BCL10 | TCR signaling |
| HP:0011947 | 0.0389077603189 | 1.0 | BCL10 MALT1 BIRC3 | Respiratory tract infection |
| GO:2000116 | 0.0402954436201 | 1.0 | BCL10 MALT1 BIRC3 | regulation of cysteine-type endopeptidase activity |
| REAC:R-HSA-2454202 | 0.041419681818 | 0.666666666667 | MALT1 BCL10 | Fc epsilon receptor (FCERI) signaling |
| HP:0012531 | 0.0434073386094 | 1.0 | BCL10 MALT1 BIRC3 | Pain |
| REAC:R-HSA-5621481 | 0.0484217025219 | 0.666666666667 | MALT1 BCL10 | C-type lectin receptors (CLRs) |
| CORUM:2744 | 0.0499402709677 | 0.333333333333 | MALT1 | TRAF2-MALT1 complex |
| CORUM:2743 | 0.0499402709677 | 0.333333333333 | MALT1 | TRAF6-MALT1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| BCL10 | MALT1 | 0.998 | 0.226 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| BIRC3 | BCL10 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | MALT1 | 0.255 | bioplex3_WMM WMM_only |
Related Complexes