hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02312.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HEXB | Beta-hexosaminidase subunit beta (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit beta) (Hexosaminidase subunit B) (Cervical cancer proto-oncogene 7 protein) (HCC-7) (N-acetyl-beta-glucosaminidase subunit beta) [Cleaved into: Beta-hexosaminidase subunit beta chain B; Beta-hexosaminidase subunit beta chain A] | 5 | UniProt NCBI |
| HEXA | Beta-hexosaminidase subunit alpha (EC 3.2.1.52) (Beta-N-acetylhexosaminidase subunit alpha) (Hexosaminidase subunit A) (N-acetyl-beta-glucosaminidase subunit alpha) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6274 | 1.70876175213e-06 | 1.0 | HEXA HEXB | HEXA-HEXB complex |
| KEGG:00603 | 1.26804361689e-05 | 1.0 | HEXA HEXB | Glycosphingolipid biosynthesis - globo and isoglobo series |
| KEGG:00604 | 1.70698179197e-05 | 1.0 | HEXA HEXB | Glycosphingolipid biosynthesis - ganglio series |
| KEGG:00511 | 2.21094784484e-05 | 1.0 | HEXA HEXB | Other glycan degradation |
| KEGG:00531 | 2.48731632544e-05 | 1.0 | HEXA HEXB | Glycosaminoglycan degradation |
| WP:WP5299 | 3.31996874241e-05 | 1.0 | HEXA HEXB | Ganglio series sphingolipid metabolism |
| WP:WP4153 | 5.7886634483e-05 | 1.0 | HEXA HEXB | Degradation pathway of sphingolipids including diseases |
| WP:WP4815 | 5.7886634483e-05 | 1.0 | HEXA HEXB | Glycosaminoglycan degradation |
| HP:0004343 | 7.17679935894e-05 | 1.0 | HEXA HEXB | Abnormal glycosphingolipid metabolism |
| REAC:R-HSA-2160916 | 9.39818963671e-05 | 1.0 | HEXA HEXB | Hyaluronan uptake and degradation |
| REAC:R-HSA-2022857 | 0.000112778275641 | 1.0 | HEXA HEXB | Keratan sulfate degradation |
| REAC:R-HSA-2024101 | 0.000112778275641 | 1.0 | HEXA HEXB | CS/DS degradation |
| KEGG:00513 | 0.000126804361689 | 1.0 | HEXA HEXB | Various types of N-glycan biosynthesis |
| REAC:R-HSA-2142845 | 0.000155497319444 | 1.0 | HEXA HEXB | Hyaluronan metabolism |
| KEGG:00520 | 0.000160943997529 | 1.0 | HEXA HEXB | Amino sugar and nucleotide sugar metabolism |
| KEGG:00600 | 0.000175737839726 | 1.0 | HEXA HEXB | Sphingolipid metabolism |
| HP:0010969 | 0.000225556551281 | 1.0 | HEXA HEXB | Abnormality of glycolipid metabolism |
| HP:0010729 | 0.000310994638887 | 1.0 | HEXA HEXB | Cherry red spot of the macula |
| GO:1905379 | 0.000468200720083 | 1.0 | HEXA HEXB | beta-N-acetylhexosaminidase complex |
| REAC:R-HSA-1638074 | 0.000743311362176 | 1.0 | HEXA HEXB | Keratan sulfate/keratin metabolism |
| HP:0002267 | 0.00102525705128 | 1.0 | HEXA HEXB | Exaggerated startle response |
| REAC:R-HSA-3560782 | 0.00120125951175 | 1.0 | HEXA HEXB | Diseases associated with glycosaminoglycan metabolism |
| KEGG:04142 | 0.00121976041763 | 1.0 | HEXA HEXB | Lysosome |
| REAC:R-HSA-1660662 | 0.00126619245833 | 1.0 | HEXA HEXB | Glycosphingolipid metabolism |
| GO:0004563 | 0.00140460216025 | 1.0 | HEXA HEXB | beta-N-acetylhexosaminidase activity |
| REAC:R-HSA-1793185 | 0.00176856841345 | 1.0 | HEXA HEXB | Chondroitin sulfate/dermatan sulfate metabolism |
| REAC:R-HSA-428157 | 0.00449062588459 | 1.0 | HEXA HEXB | Sphingolipid metabolism |
| HP:0000630 | 0.00625406801279 | 1.0 | HEXA HEXB | Abnormal retinal artery morphology |
| HP:3000036 | 0.00849254590808 | 1.0 | HEXA HEXB | Abnormal head blood vessel morphology |
| GO:0006689 | 0.00983221512175 | 1.0 | HEXA HEXB | ganglioside catabolic process |
| REAC:R-HSA-1630316 | 0.010244026704 | 1.0 | HEXA HEXB | Glycosaminoglycan metabolism |
| REAC:R-HSA-3781865 | 0.0106216630512 | 1.0 | HEXA HEXB | Diseases of glycosylation |
| REAC:R-HSA-3656248 | 0.0249718442457 | 0.5 | HEXB | Defective HEXB causes GM2G2 |
| REAC:R-HSA-3656234 | 0.0249718442457 | 0.5 | HEXA | Defective HEXA causes GM2G1 |
| CORUM:6275 | 0.0249718442457 | 0.5 | HEXB | HEXB homodimer complex |
| GO:0015929 | 0.0257510396046 | 1.0 | HEXA HEXB | hexosaminidase activity |
| REAC:R-HSA-5668914 | 0.0297170756313 | 1.0 | HEXA HEXB | Diseases of metabolism |
| GO:0046479 | 0.0309012475255 | 1.0 | HEXA HEXB | glycosphingolipid catabolic process |
| GO:0046514 | 0.0365196561665 | 1.0 | HEXA HEXB | ceramide catabolic process |
| GO:0019377 | 0.0426062655276 | 1.0 | HEXA HEXB | glycolipid catabolic process |
| HP:6000122 | 0.0499436884913 | 0.5 | HEXB | Increased urinary N-acetylglucosamine-rich oligosaccharide level |
| HP:0033978 | 0.0499436884913 | 0.5 | HEXB | Reduced beta-hexosaminidase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HEXB | HEXA | 0.999 | 0.652 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes
| Genename | Complexes |
|---|---|
| HEXB | huMAP3_02312.1 huMAP3_08135.1 huMAP3_10763.1 huMAP3_13392.1 huMAP3_14235.1 huMAP3_14589.1 |
| HEXA | huMAP3_02312.1 huMAP3_08135.1 huMAP3_10763.1 |