hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02315.1
Complex Portal: CPX-14540
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IDH3G | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma) | 5 | UniProt NCBI |
| IDH3B | Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Isocitric dehydrogenase subunit beta) (NAD(+)-specific ICDH subunit beta) | 5 | UniProt NCBI |
| GDF3 | Growth/differentiation factor 3 (GDF-3) | 5 | UniProt NCBI |
| IDH3A | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6949 | 7.01606139244e-10 | 0.75 | IDH3B IDH3G IDH3A | Isocitrate dehydrogenase [NAD], mitochondrial |
| WP:WP78 | 2.84994785564e-07 | 0.75 | IDH3B IDH3G IDH3A | TCA cycle aka Krebs or citric acid cycle |
| GO:0004449 | 3.84480164306e-07 | 0.75 | IDH3B IDH3G IDH3A | isocitrate dehydrogenase (NAD+) activity |
| GO:0005962 | 3.84480164306e-07 | 0.75 | IDH3B IDH3G IDH3A | mitochondrial isocitrate dehydrogenase complex (NAD+) |
| GO:0045242 | 3.84480164306e-07 | 0.75 | IDH3B IDH3G IDH3A | isocitrate dehydrogenase complex (NAD+) |
| KEGG:01210 | 1.39180908404e-06 | 0.75 | IDH3B IDH3G IDH3A | 2-Oxocarboxylic acid metabolism |
| KEGG:00020 | 1.39180908404e-06 | 0.75 | IDH3B IDH3G IDH3A | Citrate cycle (TCA cycle) |
| REAC:R-HSA-71403 | 1.86454808481e-06 | 0.75 | IDH3B IDH3G IDH3A | Citric acid cycle (TCA cycle) |
| GO:0004448 | 3.84440695359e-06 | 0.75 | IDH3B IDH3G IDH3A | isocitrate dehydrogenase [NAD(P)+] activity |
| GO:0006102 | 3.84440695359e-06 | 0.75 | IDH3B IDH3G IDH3A | isocitrate metabolic process |
| KEGG:01230 | 1.63910874597e-05 | 0.75 | IDH3B IDH3G IDH3A | Biosynthesis of amino acids |
| REAC:R-HSA-71406 | 3.0932996971e-05 | 0.75 | IDH3B IDH3G IDH3A | Pyruvate metabolism and Citric Acid (TCA) cycle |
| KEGG:01200 | 6.21896513057e-05 | 0.75 | IDH3B IDH3G IDH3A | Carbon metabolism |
| GO:0030062 | 6.34131776058e-05 | 0.75 | IDH3B IDH3G IDH3A | mitochondrial tricarboxylic acid cycle enzyme complex |
| GO:0072350 | 8.45465618902e-05 | 0.75 | IDH3B IDH3G IDH3A | tricarboxylic acid metabolic process |
| GO:0045239 | 0.000261258639543 | 0.75 | IDH3B IDH3G IDH3A | tricarboxylic acid cycle enzyme complex |
| GO:0006099 | 0.000777349058504 | 0.75 | IDH3B IDH3G IDH3A | tricarboxylic acid cycle |
| REAC:R-HSA-1428517 | 0.00109943198837 | 0.75 | IDH3B IDH3G IDH3A | The citric acid (TCA) cycle and respiratory electron transport |
| HPA:0090183 | 0.0296286402726 | 0.75 | IDH3B IDH3G IDH3A | cerebellum; cells in granular layer[High] |
| GO:1902652 | 0.0339114962397 | 0.75 | IDH3B IDH3G IDH3A | secondary alcohol metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| IDH3G | IDH3B | 1.0 | 0.538 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction | |
| IDH3B | IDH3A | 0.999 | 0.846 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM gupta_WMM fraction treiber_WMM | |
| IDH3G | IDH3A | 0.999 | 0.808 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM fraction | |
| IDH3B | GDF3 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| GDF3 | IDH3A | 0.01 | WMM_only treiber_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| IDH3G | huMAP3_02315.1 huMAP3_09052.1 huMAP3_12348.1 |
| IDH3B | huMAP3_02315.1 huMAP3_12348.1 |
| GDF3 | huMAP3_02315.1 huMAP3_04071.1 huMAP3_11339.1 huMAP3_14620.1 |
| IDH3A | huMAP3_02315.1 huMAP3_12348.1 |