hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02322.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SHC3 | SHC-transforming protein 3 (Neuronal Shc) (N-Shc) (Protein Rai) (SHC-transforming protein C) (Src homology 2 domain-containing-transforming protein C3) (SH2 domain protein C3) | 5 | UniProt NCBI |
| SHC4 | SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04917 | 0.000307419292249 | 1.0 | SHC3 SHC4 | Prolactin signaling pathway |
| KEGG:05214 | 0.00037033376401 | 1.0 | SHC3 SHC4 | Glioma |
| KEGG:01521 | 0.000439100744773 | 1.0 | SHC3 SHC4 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05220 | 0.000439100744773 | 1.0 | SHC3 SHC4 | Chronic myeloid leukemia |
| KEGG:04012 | 0.000463323629249 | 1.0 | SHC3 SHC4 | ErbB signaling pathway |
| KEGG:05100 | 0.000463323629249 | 1.0 | SHC3 SHC4 | Bacterial invasion of epithelial cells |
| KEGG:01522 | 0.000539893955346 | 1.0 | SHC3 SHC4 | Endocrine resistance |
| KEGG:04915 | 0.000680516741066 | 1.0 | SHC3 SHC4 | Estrogen signaling pathway |
| KEGG:04722 | 0.000804719987643 | 1.0 | SHC3 SHC4 | Neurotrophin signaling pathway |
| KEGG:04935 | 0.000804719987643 | 1.0 | SHC3 SHC4 | Growth hormone synthesis, secretion and action |
| KEGG:04926 | 0.000939327694667 | 1.0 | SHC3 SHC4 | Relaxin signaling pathway |
| KEGG:04650 | 0.00095688522167 | 1.0 | SHC3 SHC4 | Natural killer cell mediated cytotoxicity |
| KEGG:04072 | 0.00108433986214 | 1.0 | SHC3 SHC4 | Phospholipase D signaling pathway |
| KEGG:04910 | 0.00128023634398 | 1.0 | SHC3 SHC4 | Insulin signaling pathway |
| KEGG:05224 | 0.00130072012548 | 1.0 | SHC3 SHC4 | Breast cancer |
| WP:WP4806 | 0.00131138765325 | 1.0 | SHC3 SHC4 | EGFR tyrosine kinase inhibitor resistance |
| WP:WP673 | 0.00137906393915 | 1.0 | SHC3 SHC4 | ErbB signaling pathway |
| KEGG:05226 | 0.00138428094844 | 1.0 | SHC3 SHC4 | Gastric cancer |
| KEGG:04062 | 0.00155920593969 | 1.0 | SHC3 SHC4 | Chemokine signaling pathway |
| KEGG:05034 | 0.00179249345126 | 1.0 | SHC3 SHC4 | Alcoholism |
| KEGG:05225 | 0.00204203793228 | 1.0 | SHC3 SHC4 | Hepatocellular carcinoma |
| KEGG:04510 | 0.00241871191437 | 1.0 | SHC3 SHC4 | Focal adhesion |
| KEGG:04014 | 0.00273702337615 | 1.0 | SHC3 SHC4 | Ras signaling pathway |
| WP:WP3929 | 0.00309012475255 | 1.0 | SHC3 SHC4 | Chemokine signaling pathway |
| WP:WP2380 | 0.00319355454799 | 1.0 | SHC3 SHC4 | Brain derived neurotrophic factor BDNF signaling pathway |
| WP:WP4262 | 0.00373624174627 | 1.0 | SHC3 SHC4 | Breast cancer pathway |
| WP:WP4223 | 0.00456751084292 | 1.0 | SHC3 SHC4 | Ras signaling |
| WP:WP306 | 0.00633262755764 | 1.0 | SHC3 SHC4 | Focal adhesion |
| CORUM:903 | 0.0499419797295 | 0.5 | SHC3 | RET-Rai complex |
| CORUM:904 | 0.0499419797295 | 0.5 | SHC3 | SHC3-GAB1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SHC4 | SHC3 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| SHC3 | huMAP3_02322.1 huMAP3_05315.1 |
| SHC4 | huMAP3_01821.1 huMAP3_02322.1 huMAP3_05315.1 |