hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02340.1
Complex Portal: CPX-13356
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MATCAP1 | Microtubule-associated tyrosine carboxypeptidase 1 (EC 3.4.17.17) (Microtubule-associated tyrosine carboxypeptidase) | 5 | UniProt NCBI |
| EGLN1 | Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20) | 5 | UniProt NCBI |
| BDH2 | Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.-) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (EC 1.1.1.30) (4-oxo-L-proline reductase) (EC 1.1.1.104) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1) | 5 | UniProt NCBI |
| CREBBP | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | 5 | UniProt NCBI |
| CITED1 | Cbp/p300-interacting transactivator 1 (Melanocyte-specific protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8866907 | 0.000683310775372 | 0.4 | CITED1 CREBBP | Activation of the TFAP2 (AP-2) family of transcription factors |
| WP:WP4241 | 0.00290547066497 | 0.4 | EGLN1 CREBBP | Type 2 papillary renal cell carcinoma |
| WP:WP5236 | 0.00631928190743 | 0.4 | CITED1 EGLN1 | Markers of kidney cell lineage |
| REAC:R-HSA-8864260 | 0.00799229651072 | 0.4 | CITED1 CREBBP | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
| KEGG:05211 | 0.00937366158534 | 0.4 | EGLN1 CREBBP | Renal cell carcinoma |
| KEGG:04066 | 0.0217595858915 | 0.4 | EGLN1 CREBBP | HIF-1 signaling pathway |
| REAC:R-HSA-1234174 | 0.0363707033179 | 0.4 | EGLN1 CREBBP | Cellular response to hypoxia |
| WP:WP366 | 0.0406395857275 | 0.4 | CITED1 CREBBP | TGF beta signaling pathway |
| CORUM:5198 | 0.0498708842806 | 0.2 | CREBBP | CBP-RARA-RXRA-DNA complex, ligand stimulated |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| BDH2 | CITED1 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CREBBP | CITED1 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MATCAP1 | CITED1 | 0.987 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| EGLN1 | CITED1 | 0.974 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CREBBP | BDH2 | 0.905 | 0.024 | bioplex3_WMM WMM_only | |
| CREBBP | MATCAP1 | 0.415 | bioplex3_WMM WMM_only | ||
| MATCAP1 | BDH2 | 0.415 | bioplex3_WMM WMM_only | ||
| EGLN1 | BDH2 | 0.351 | 0.026 | bioplex3_WMM WMM_only | |
| CREBBP | EGLN1 | 0.122 | 0.09 | bioplex3_WMM youn_WMM WMM_only | |
| MATCAP1 | EGLN1 | 0.102 | bioplex3_WMM WMM_only |
Related Complexes