hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02343.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SKIC8 | Superkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)] | 5 | UniProt NCBI |
| PAF1 | RNA polymerase II-associated factor 1 homolog (hPAF1) (Pancreatic differentiation protein 2) | 5 | UniProt NCBI |
| LEO1 | RNA polymerase-associated protein LEO1 (Replicative senescence down-regulated leo1-like protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1167 | 2.33868713081e-09 | 1.0 | SKIC8 PAF1 LEO1 | Paf complex |
| GO:0016593 | 3.36420143768e-06 | 1.0 | SKIC8 PAF1 LEO1 | Cdc73/Paf1 complex |
| REAC:R-HSA-8866654 | 1.1573599509e-05 | 1.0 | SKIC8 PAF1 LEO1 | E3 ubiquitin ligases ubiquitinate target proteins |
| REAC:R-HSA-75955 | 1.365277865e-05 | 1.0 | SKIC8 PAF1 LEO1 | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 1.365277865e-05 | 1.0 | SKIC8 PAF1 LEO1 | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-8852135 | 3.02470171978e-05 | 1.0 | SKIC8 PAF1 LEO1 | Protein ubiquitination |
| REAC:R-HSA-674695 | 3.68984307198e-05 | 1.0 | SKIC8 PAF1 LEO1 | RNA Polymerase II Pre-transcription Events |
| GO:0008023 | 0.00155858646605 | 1.0 | SKIC8 PAF1 LEO1 | transcription elongation factor complex |
| GO:0045638 | 0.00381702295119 | 1.0 | SKIC8 PAF1 LEO1 | negative regulation of myeloid cell differentiation |
| GO:0016591 | 0.00481715197859 | 1.0 | SKIC8 PAF1 LEO1 | RNA polymerase II, holoenzyme |
| WP:WP2853 | 0.00738685655077 | 0.666666666667 | LEO1 PAF1 | Endoderm differentiation |
| GO:0055029 | 0.0120707547584 | 1.0 | SKIC8 PAF1 LEO1 | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 0.0124731132503 | 1.0 | SKIC8 PAF1 LEO1 | DNA-directed RNA polymerase complex |
| GO:0030880 | 0.013733631469 | 1.0 | SKIC8 PAF1 LEO1 | RNA polymerase complex |
| GO:0006368 | 0.0150763323228 | 1.0 | SKIC8 PAF1 LEO1 | transcription elongation by RNA polymerase II |
| GO:0031442 | 0.0210651876021 | 0.666666666667 | LEO1 PAF1 | positive regulation of mRNA 3'-end processing |
| GO:0006354 | 0.0243625856112 | 1.0 | SKIC8 PAF1 LEO1 | DNA-templated transcription elongation |
| GO:0045637 | 0.0376871301854 | 1.0 | SKIC8 PAF1 LEO1 | regulation of myeloid cell differentiation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SKIC8 | LEO1 | 1.0 | 0.186 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM |
| LEO1 | PAF1 | 1.0 | 0.95 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM |
| SKIC8 | PAF1 | 1.0 | 0.264 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 fraction boldt_WMM |
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