hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02347.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SKA1 | Spindle and kinetochore-associated protein 1 | 5 | UniProt NCBI |
| SKA2 | Spindle and kinetochore-associated protein 2 (Protein FAM33A) | 5 | UniProt NCBI |
| SKA3 | Spindle and kinetochore-associated protein 3 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000940 | 0.000109576846827 | 1.0 | SKA3 SKA1 SKA2 | outer kinetochore |
| GO:0051315 | 0.000194546963139 | 1.0 | SKA3 SKA1 SKA2 | attachment of mitotic spindle microtubules to kinetochore |
| GO:0008608 | 0.0018839528051 | 1.0 | SKA3 SKA1 SKA2 | attachment of spindle microtubules to kinetochore |
| GO:0007080 | 0.0028124724019 | 1.0 | SKA3 SKA1 SKA2 | mitotic metaphase chromosome alignment |
| GO:0005876 | 0.00623088554274 | 1.0 | SKA3 SKA1 SKA2 | spindle microtubule |
| GO:0031110 | 0.00731242824493 | 1.0 | SKA3 SKA1 SKA2 | regulation of microtubule polymerization or depolymerization |
| GO:0051310 | 0.0116771431902 | 1.0 | SKA3 SKA1 SKA2 | metaphase chromosome alignment |
| GO:0051303 | 0.0128843147861 | 1.0 | SKA3 SKA1 SKA2 | establishment of chromosome localization |
| GO:0050000 | 0.0150763323228 | 1.0 | SKA3 SKA1 SKA2 | chromosome localization |
| GO:0031109 | 0.0219076797621 | 1.0 | SKA3 SKA1 SKA2 | microtubule polymerization or depolymerization |
| REAC:R-HSA-141424 | 0.0284248695791 | 0.666666666667 | SKA1 SKA2 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 0.0284248695791 | 0.666666666667 | SKA1 SKA2 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| GO:0070507 | 0.0343879058955 | 1.0 | SKA3 SKA1 SKA2 | regulation of microtubule cytoskeleton organization |
| REAC:R-HSA-69618 | 0.0392065258044 | 0.666666666667 | SKA1 SKA2 | Mitotic Spindle Checkpoint |
| GO:0000776 | 0.0402954436201 | 1.0 | SKA3 SKA1 SKA2 | kinetochore |
| REAC:R-HSA-9648025 | 0.0429286997388 | 0.666666666667 | SKA1 SKA2 | EML4 and NUDC in mitotic spindle formation |
| GO:0000779 | 0.0439566559847 | 1.0 | SKA3 SKA1 SKA2 | condensed chromosome, centromeric region |
| REAC:R-HSA-2500257 | 0.049233254294 | 0.666666666667 | SKA1 SKA2 | Resolution of Sister Chromatid Cohesion |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SKA1 | SKA2 | 1.0 | 0.302 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| SKA3 | SKA2 | 1.0 | 0.446 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| SKA1 | SKA3 | 1.0 | 0.636 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
Related Complexes