hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02357.1
Complex Portal: CPX-13420
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PPP1R8 | Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)] | 5 | UniProt NCBI |
| CSRNP2 | Cysteine/serine-rich nuclear protein 2 (CSRNP-2) (Protein FAM130A1) (TGF-beta-induced apoptosis protein 12) (TAIP-12) | 4 | UniProt NCBI |
| CSRNP3 | Cysteine/serine-rich nuclear protein 3 (CSRNP-3) (Protein FAM130A2) (TGF-beta-induced apoptosis protein 2) (TAIP-2) | 4 | UniProt NCBI |
| PPP1R11 | E3 ubiquitin-protein ligase PPP1R11 (EC 2.3.2.27) (Hemochromatosis candidate gene V protein) (HCG V) (Protein phosphatase 1 regulatory subunit 11) (Protein phosphatase inhibitor 3) | 5 | UniProt NCBI |
| CNST | Consortin | 5 | UniProt NCBI |
| ZFYVE16 | Zinc finger FYVE domain-containing protein 16 (Endofin) (Endosome-associated FYVE domain protein) | 5 | UniProt NCBI |
| PPP1CC | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit) | 5 | UniProt NCBI |
| LMTK2 | Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2) | 5 | UniProt NCBI |
| KIF18A | Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4861 | 0.000143918669646 | 0.333333333333 | PPP1CC PPP1R8 PPP1R11 | Endoplasmic reticulum stress response in coronavirus infection |
| GO:0004864 | 0.0106791414882 | 0.333333333333 | LMTK2 PPP1R8 PPP1R11 | protein phosphatase inhibitor activity |
| GO:0019212 | 0.0184449339515 | 0.333333333333 | LMTK2 PPP1R8 PPP1R11 | phosphatase inhibitor activity |
| HPA:0460663 | 0.0362521780664 | 0.444444444444 | CSRNP2 KIF18A PPP1R8 CNST | skin 1; keratinocytes[High] |
| HPA:0460662 | 0.0395781366172 | 0.777777777778 | KIF18A CSRNP3 CNST PPP1R8 CSRNP2 PPP1R11 ZFYVE16 | skin 1; keratinocytes[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CNST | PPP1CC | 1.0 | 0.198 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| PPP1R8 | PPP1CC | 0.999 | 0.262 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 fraction boldt_WMM | |
| ZFYVE16 | PPP1CC | 0.999 | 0.07 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| PPP1CC | KIF18A | 0.999 | 0.296 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM | |
| PPP1CC | LMTK2 | 0.997 | 0.146 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| PPP1R11 | PPP1CC | 0.996 | 0.116 |
structurally_consistent (P62136)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| CSRNP2 | PPP1CC | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CSRNP3 | PPP1CC | 0.976 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PPP1R8 | LMTK2 | 0.967 | 0.094 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PPP1R11 | CNST | 0.964 | 0.19 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| CNST | ZFYVE16 | 0.962 | 0.044 |
mutually_exclusive (P62136)
|
bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| PPP1R11 | ZFYVE16 | 0.959 | 0.018 |
mutually_exclusive (P62136)
|
bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| ZFYVE16 | KIF18A | 0.959 | 0.07 |
mutually_exclusive (P62136)
|
bioplex_WMM bioplex3_WMM WMM_only boldt_WMM |
| CNST | LMTK2 | 0.959 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only | |
| LMTK2 | KIF18A | 0.959 | 0.114 | bioplex_WMM bioplex3_WMM WMM_only | |
| PPP1R11 | LMTK2 | 0.959 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZFYVE16 | LMTK2 | 0.956 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only | |
| PPP1R8 | ZFYVE16 | 0.954 | 0.044 |
mutually_exclusive (P62136)
|
bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM |
| PPP1R11 | KIF18A | 0.927 | 0.106 |
mutually_exclusive (P62136)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| PPP1R8 | PPP1R11 | 0.921 | 0.03 |
mutually_exclusive (P62136)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| CNST | KIF18A | 0.92 | 0.07 |
mutually_exclusive (P62136)
|
bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| PPP1R8 | CNST | 0.914 | 0.092 |
mutually_exclusive (P62136)
|
bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| PPP1R8 | KIF18A | 0.834 | 0.1 |
mutually_exclusive (P62136)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| CSRNP2 | PPP1R11 | 0.737 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| CSRNP2 | KIF18A | 0.653 |
mutually_exclusive (P62136)
|
bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| PPP1R8 | CSRNP2 | 0.653 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | ||
| CSRNP2 | CNST | 0.575 |
mutually_exclusive (P62136)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| CSRNP2 | ZFYVE16 | 0.575 |
mutually_exclusive (P62136)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| CSRNP3 | CNST | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CSRNP3 | ZFYVE16 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CSRNP3 | LMTK2 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CSRNP2 | CSRNP3 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CSRNP3 | PPP1R11 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CSRNP3 | KIF18A | 0.543 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CSRNP2 | LMTK2 | 0.513 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PPP1R8 | CSRNP3 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes