hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02362.1

Complex Portal: CPX-16048

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
SEPTIN1	Septin-1 (LARP) (Peanut-like protein 3) (Serologically defined breast cancer antigen NY-BR-24)	5	UniProt NCBI
SEPTIN12	Septin-12	5	UniProt NCBI
SEPTIN7	Septin-7 (CDC10 protein homolog)	5	UniProt NCBI
SEPTIN2	Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5)	5	UniProt NCBI
SEPTIN9	Septin-9 (MLL septin-like fusion protein MSF-A) (MLL septin-like fusion protein) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1)	5	UniProt NCBI
SEPTIN11	Septin-11	5	UniProt NCBI
SEPTIN6	Septin-6	5	UniProt NCBI
SEPTIN4	Septin-4 (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Peanut-like protein 2)	5	UniProt NCBI
SEPTIN10	Septin-10	5	UniProt NCBI
SEPTIN3	Neuronal-specific septin-3	5	UniProt NCBI
SEPTIN5	Septin-5 (Cell division control-related protein 1) (CDCrel-1) (Peanut-like protein 1)	5	UniProt NCBI
SEPTIN8	Septin-8	5	UniProt NCBI
CDC42EP4	Cdc42 effector protein 4 (Binder of Rho GTPases 4)	5	UniProt NCBI
SEPTIN14	Septin-14	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0032156	3.15727334806e-39	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	septin cytoskeleton
GO:0031105	3.15727334806e-39	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	septin complex
GO:0005940	3.15727334806e-39	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	septin ring
GO:0032153	1.11775548067e-27	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	cell division site
GO:0061640	2.93628922047e-23	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	cytoskeleton-dependent cytokinesis
GO:0000910	1.15681492152e-20	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	cytokinesis
GO:0005938	4.2479782839e-20	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	cell cortex
GO:0051301	2.51503274534e-18	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	cell division
GO:0003924	3.51404415064e-18	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	GTPase activity
GO:0017111	8.14931569652e-16	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	ribonucleoside triphosphate phosphatase activity
GO:0016818	3.7726147615e-15	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0016462	3.7726147615e-15	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	pyrophosphatase activity
GO:0016817	3.7726147615e-15	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	hydrolase activity, acting on acid anhydrides
CORUM:1345	1.88171091104e-14	0.357142857143	SEPTIN8 SEPTIN11 SEPTIN9 SEPTIN7 SEPTIN2	Septin complex
KEGG:05100	5.96168827974e-14	0.571428571429	SEPTIN11 SEPTIN9 SEPTIN3 SEPTIN2 SEPTIN12 SEPTIN1 SEPTIN8 SEPTIN6	Bacterial invasion of epithelial cells
GO:0015630	2.75342712077e-12	1.0	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 CDC42EP4 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	microtubule cytoskeleton
GO:0097227	1.80267905278e-11	0.357142857143	SEPTIN12 SEPTIN4 SEPTIN6 SEPTIN7 SEPTIN2	sperm annulus
GO:0060090	9.49679917102e-11	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	molecular adaptor activity
GO:0022402	3.37826657791e-10	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	cell cycle process
KEGG:05131	4.61629971312e-10	0.571428571429	SEPTIN11 SEPTIN9 SEPTIN3 SEPTIN2 SEPTIN12 SEPTIN8 SEPTIN7 SEPTIN6	Shigellosis
GO:0005856	8.59562005566e-10	1.0	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 CDC42EP4 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	cytoskeleton
GO:0007049	8.49327485639e-09	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	cell cycle
GO:0016787	1.06838856462e-07	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	hydrolase activity
GO:0071944	0.000128471550099	1.0	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 CDC42EP4 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	cell periphery
GO:0043228	0.000230814911387	1.0	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 CDC42EP4 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	non-membrane-bounded organelle
GO:0043232	0.000230814911387	1.0	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 CDC42EP4 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	intracellular non-membrane-bounded organelle
WP:WP5224	0.000277667759616	0.285714285714	SEPTIN12 SEPTIN4 SEPTIN2 SEPTIN6	2q37 copy number variation syndrome
GO:0036126	0.000567467813716	0.357142857143	SEPTIN12 SEPTIN4 SEPTIN6 SEPTIN7 SEPTIN2	sperm flagellum
GO:0098793	0.000810425349962	0.428571428571	SEPTIN3 SEPTIN4 SEPTIN2 SEPTIN5 SEPTIN1 SEPTIN8	presynapse
GO:0097729	0.00110804486035	0.357142857143	SEPTIN12 SEPTIN4 SEPTIN6 SEPTIN7 SEPTIN2	9+2 motile cilium
GO:0031514	0.00447662055434	0.357142857143	SEPTIN12 SEPTIN4 SEPTIN6 SEPTIN7 SEPTIN2	motile cilium
GO:0097517	0.00810452426521	0.285714285714	SEPTIN12 SEPTIN11 SEPTIN7 SEPTIN9	contractile actin filament bundle
GO:0001725	0.00810452426521	0.285714285714	SEPTIN12 SEPTIN11 SEPTIN7 SEPTIN9	stress fiber
GO:0032432	0.0116315040525	0.285714285714	SEPTIN12 SEPTIN11 SEPTIN7 SEPTIN9	actin filament bundle
GO:0042641	0.0124554894308	0.285714285714	SEPTIN12 SEPTIN11 SEPTIN7 SEPTIN9	actomyosin
WP:WP4657	0.0124841019319	0.214285714286	SEPTIN8 SEPTIN11 SEPTIN5	22q11 2 copy number variation syndrome
GO:0015629	0.0351357937908	0.428571428571	SEPTIN11 SEPTIN9 SEPTIN2 SEPTIN12 CDC42EP4 SEPTIN7	actin cytoskeleton
GO:0003824	0.0355625074729	0.928571428571	SEPTIN11 SEPTIN9 SEPTIN10 SEPTIN3 SEPTIN2 SEPTIN4 SEPTIN12 SEPTIN5 SEPTIN1 SEPTIN14 SEPTIN8 SEPTIN7 SEPTIN6	catalytic activity

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
SEPTIN11	SEPTIN8	1.0	0.534
SEPTIN10	SEPTIN8	1.0	0.08
SEPTIN2	SEPTIN9	1.0	0.518	structurally_consistent (dimer)
SEPTIN9	SEPTIN11	1.0	0.288
SEPTIN2	SEPTIN10	1.0	0.192	structurally_consistent (dimer)
SEPTIN7	SEPTIN9	1.0	0.508
SEPTIN7	SEPTIN10	1.0	0.172
SEPTIN2	SEPTIN6	1.0	0.36
SEPTIN7	SEPTIN8	1.0	0.84
SEPTIN9	SEPTIN10	1.0	0.206
SEPTIN2	SEPTIN8	1.0	0.908
SEPTIN5	SEPTIN8	1.0	0.094
SEPTIN7	SEPTIN2	1.0	0.968
SEPTIN2	SEPTIN11	1.0	0.702	structurally_consistent (dimer)
SEPTIN7	SEPTIN6	1.0	0.54
SEPTIN7	SEPTIN11	1.0	0.874
SEPTIN11	SEPTIN5	1.0	0.04	mutually_exclusive (Q15019)
SEPTIN11	SEPTIN6	1.0	0.352
SEPTIN11	SEPTIN10	1.0	0.096	mutually_exclusive (Q15019)
SEPTIN7	SEPTIN14	1.0
SEPTIN6	SEPTIN3	1.0	0.326	mutually_exclusive (Q99719)
SEPTIN9	SEPTIN6	1.0	0.19
SEPTIN7	SEPTIN5	0.999	0.096
SEPTIN3	SEPTIN8	0.999	0.162
SEPTIN2	SEPTIN5	0.999	0.104	structurally_consistent (dimer)
SEPTIN1	SEPTIN4	0.999	0.04
SEPTIN7	SEPTIN4	0.999	0.278
SEPTIN1	SEPTIN3	0.999	0.044	mutually_exclusive (Q99719)
SEPTIN9	SEPTIN8	0.999	0.352
SEPTIN1	SEPTIN5	0.999	0.044	structurally_consistent (dimer)
SEPTIN9	SEPTIN3	0.999	0.132
SEPTIN10	SEPTIN14	0.999
SEPTIN6	SEPTIN5	0.999	0.102	structurally_consistent (dimer)
SEPTIN2	SEPTIN3	0.999	0.33
SEPTIN1	SEPTIN6	0.999	0.012	mutually_exclusive (Q99719)
SEPTIN10	SEPTIN3	0.999	0.092
SEPTIN3	SEPTIN5	0.999	0.156	structurally_consistent (dimer)
SEPTIN11	SEPTIN4	0.999	0.11
SEPTIN12	SEPTIN6	0.999
SEPTIN6	SEPTIN10	0.999	0.02	mutually_exclusive (Q99719)
SEPTIN10	SEPTIN5	0.999	0.04	mutually_exclusive (Q15019) structurally_consistent (dimer)
SEPTIN1	SEPTIN2	0.999	0.128
SEPTIN1	SEPTIN9	0.999	0.076	structurally_consistent (dimer)
SEPTIN11	SEPTIN3	0.999	0.188
SEPTIN6	SEPTIN8	0.999	0.436
SEPTIN1	SEPTIN7	0.998	0.0506666666667
SEPTIN1	SEPTIN11	0.998	0.02
SEPTIN12	SEPTIN2	0.998
SEPTIN12	SEPTIN11	0.998
SEPTIN12	SEPTIN8	0.998
SEPTIN1	SEPTIN8	0.998	0.054
SEPTIN12	SEPTIN7	0.998
SEPTIN3	SEPTIN14	0.998
SEPTIN1	SEPTIN10	0.998	0.054
SEPTIN7	SEPTIN3	0.998	0.198
SEPTIN12	SEPTIN5	0.997
SEPTIN2	SEPTIN14	0.997		structurally_consistent (dimer)
SEPTIN6	SEPTIN14	0.997
SEPTIN11	SEPTIN14	0.997
SEPTIN4	SEPTIN3	0.997	0.388
SEPTIN9	SEPTIN5	0.997	0.064	mutually_exclusive (Q8WYJ6)
SEPTIN2	SEPTIN4	0.996	0.2
SEPTIN4	SEPTIN10	0.996	0.05
SEPTIN7	CDC42EP4	0.996	0.08
SEPTIN12	SEPTIN10	0.996
SEPTIN9	SEPTIN14	0.995		mutually_exclusive (Q15019)
SEPTIN8	SEPTIN14	0.995
SEPTIN9	CDC42EP4	0.994	0.124
SEPTIN2	CDC42EP4	0.994	0.136
SEPTIN6	SEPTIN4	0.993	0.306
SEPTIN11	CDC42EP4	0.993	0.028
SEPTIN4	SEPTIN8	0.993	0.102
SEPTIN4	SEPTIN5	0.993	0.424
SEPTIN9	SEPTIN4	0.993	0.266
SEPTIN10	CDC42EP4	0.993	0.054
SEPTIN6	CDC42EP4	0.992	0.024
SEPTIN8	CDC42EP4	0.99	0.104
SEPTIN3	CDC42EP4	0.98	0.08
SEPTIN4	SEPTIN14	0.98
SEPTIN12	SEPTIN4	0.98
SEPTIN5	SEPTIN14	0.974
SEPTIN5	CDC42EP4	0.973	0.07
SEPTIN12	SEPTIN3	0.972
CDC42EP4	SEPTIN14	0.94
SEPTIN4	CDC42EP4	0.229	0.114
SEPTIN12	SEPTIN9	0.053

Related Complexes

Genename	Complexes
SEPTIN1	huMAP3_02362.1
SEPTIN12	huMAP3_02362.1
SEPTIN7	huMAP3_02362.1
SEPTIN2	huMAP3_02362.1
SEPTIN9	huMAP3_02362.1
SEPTIN11	huMAP3_02362.1
SEPTIN6	huMAP3_02362.1
SEPTIN4	huMAP3_02362.1
SEPTIN10	huMAP3_02362.1
SEPTIN3	huMAP3_02362.1
SEPTIN5	huMAP3_02362.1
SEPTIN8	huMAP3_02362.1
CDC42EP4	huMAP3_02362.1 huMAP3_13397.1
SEPTIN14	huMAP3_02362.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_02362.1

Complex Portal: CPX-16048