hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02367.1
Complex Portal: CPX-15709
Confidence: Extremely High  
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MRPS26 | Small ribosomal subunit protein mS26 (28S ribosomal protein S13, mitochondrial) (MRP-S13) (S13mt) (28S ribosomal protein S26, mitochondrial) (MRP-S26) (S26mt) | 4 | UniProt   NCBI |
| NOA1 | Nitric oxide-associated protein 1 | 5 | UniProt   NCBI |
| ZC3H3 | Zinc finger CCCH domain-containing protein 3 (Smad-interacting CPSF-like factor) | 5 | UniProt   NCBI |
| METTL17 | Methyltransferase-like protein 17, mitochondrial (EC 2.1.1.-) (False p73 target gene protein) (Methyltransferase 11 domain-containing protein 1) (Protein RSM22 homolog, mitochondrial) | 5 | UniProt   NCBI |
| MRPS11 | Small ribosomal subunit protein uS11m (28S ribosomal protein S11, mitochondrial) (MRP-S11) (S11mt) (Cervical cancer proto-oncogene 2 protein) (HCC-2) | 4 | UniProt   NCBI |
| ZNF777 | Zinc finger protein 777 | 5 | UniProt   NCBI |
| TRA2A | Transformer-2 protein homolog alpha (TRA-2 alpha) (TRA2-alpha) (Transformer-2 protein homolog A) | 5 | UniProt   NCBI |
| MRPS12 | Small ribosomal subunit protein uS12m (28S ribosomal protein S12, mitochondrial) (MRP-S12) (S12mt) (MT-RPS12) | 4 | UniProt   NCBI |
| MRPS24 | Small ribosomal subunit protein uS3m (28S ribosomal protein S24, mitochondrial) (MRP-S24) (S24mt) (bMRP-47) (bMRP47) | 3 | UniProt   NCBI |
| MRPL3 | Large ribosomal subunit protein uL3m (39S ribosomal protein L3, mitochondrial) (L3mt) (MRP-L3) | 4 | UniProt   NCBI |
| AURKAIP1 | Small ribosomal subunit protein mS38 (28S ribosomal protein S38, mitochondrial) (MRP-S38) (Aurora kinase A-interacting protein) (AURKA-interacting protein) | 5 | UniProt   NCBI |
| MRPS6 | Small ribosomal subunit protein bS6m (28S ribosomal protein S6, mitochondrial) (MRP-S6) (S6mt) | 5 | UniProt   NCBI |
| MCAT | Malonyl-CoA-acyl carrier protein transacylase, mitochondrial (MCT) (EC 2.3.1.39) (Mitochondrial malonyl CoA:ACP acyltransferase) (Mitochondrial malonyltransferase) ([Acyl-carrier-protein] malonyltransferase) | 5 | UniProt   NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
|   REAC:R-HSA-5419276 | 9.43290325511e-11 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | Mitochondrial translation termination |
|   REAC:R-HSA-5368286 | 9.43290325511e-11 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | Mitochondrial translation initiation |
|   REAC:R-HSA-5389840 | 9.43290325511e-11 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | Mitochondrial translation elongation |
|   REAC:R-HSA-5368287 | 1.52601278109e-10 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | Mitochondrial translation |
|   CORUM:320 | 1.77785518933e-09 | 0.461538461538 | MRPS26 MRPS6 MRPS11 MRPS12 MRPL3 MRPS24 | 55S ribosome, mitochondrial |
|   CORUM:315 | 1.83450068409e-09 | 0.384615384615 | MRPS6 MRPS12 MRPS24 MRPS26 MRPS11 | 28S ribosomal subunit, mitochondrial |
|   GO:0000314 | 5.68920262044e-09 | 0.461538461538 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPS24 | organellar small ribosomal subunit |
|   GO:0005763 | 5.68920262044e-09 | 0.461538461538 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPS24 | mitochondrial small ribosomal subunit |
|   GO:0000313 | 1.8747239249e-08 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | organellar ribosome |
|   GO:0005761 | 1.8747239249e-08 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | mitochondrial ribosome |
|   GO:0032543 | 2.32353514715e-07 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | mitochondrial translation |
|   GO:0005759 | 2.73620169494e-07 | 0.692307692308 | MCAT MRPS26 MRPS6 MRPS11 METTL17 AURKAIP1 MRPS12 MRPL3 MRPS24 | mitochondrial matrix |
|   REAC:R-HSA-72766 | 4.54672892303e-07 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | Translation |
|   GO:0140053 | 9.7724754575e-07 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | mitochondrial gene expression |
|   GO:0015935 | 1.24197683531e-06 | 0.461538461538 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPS24 | small ribosomal subunit |
|   GO:0044391 | 3.33311295411e-06 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | ribosomal subunit |
|   GO:0005840 | 9.12645611478e-06 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | ribosome |
|   GO:0005743 | 1.4572519059e-05 | 0.615384615385 | NOA1 MRPS26 MRPS6 MRPS11 AURKAIP1 MRPS12 MRPL3 MRPS24 | mitochondrial inner membrane |
|   GO:0019866 | 2.28961385111e-05 | 0.615384615385 | NOA1 MRPS26 MRPS6 MRPS11 AURKAIP1 MRPS12 MRPL3 MRPS24 | organelle inner membrane |
|   GO:0098798 | 7.73488609076e-05 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | mitochondrial protein-containing complex |
|   GO:0031966 | 0.000208404308357 | 0.615384615385 | NOA1 MRPS26 MRPS6 MRPS11 AURKAIP1 MRPS12 MRPL3 MRPS24 | mitochondrial membrane |
|   KEGG:03010 | 0.000229752845331 | 0.307692307692 | MRPS12 MRPS6 MRPS11 MRPL3 | Ribosome |
|   GO:0005739 | 0.000289450402857 | 0.769230769231 | NOA1 MRPS26 MCAT MRPS6 MRPS11 METTL17 AURKAIP1 MRPL3 MRPS12 MRPS24 | mitochondrion |
|   GO:0005740 | 0.00034790669064 | 0.615384615385 | NOA1 MRPS26 MRPS6 MRPS11 AURKAIP1 MRPS12 MRPL3 MRPS24 | mitochondrial envelope |
|   GO:1990904 | 0.000371898449967 | 0.615384615385 | TRA2A MRPS6 MRPS11 AURKAIP1 MRPS12 MRPL3 MRPS24 MRPS26 | ribonucleoprotein complex |
|   GO:0003735 | 0.00523053993714 | 0.384615384615 | MRPL3 MRPS12 MRPS6 MRPS11 MRPS24 | structural constituent of ribosome |
|   GO:0006412 | 0.00607832048563 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | translation |
|   GO:0043043 | 0.00743236750508 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | peptide biosynthetic process |
|   GO:0031967 | 0.0117901827978 | 0.615384615385 | NOA1 MRPS26 MRPS6 MRPS11 AURKAIP1 MRPS12 MRPL3 MRPS24 | organelle envelope |
|   GO:0031975 | 0.0117901827978 | 0.615384615385 | NOA1 MRPS26 MRPS6 MRPS11 AURKAIP1 MRPS12 MRPL3 MRPS24 | envelope |
|   GO:0003723 | 0.0165832809285 | 0.692307692308 | NOA1 TRA2A MCAT MRPS6 MRPS11 MRPL3 MRPS12 MRPS24 MRPS26 | RNA binding |
|   GO:0043604 | 0.0248417906677 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | amide biosynthetic process |
|   GO:0006518 | 0.0272364479095 | 0.538461538462 | MRPS26 MRPS6 AURKAIP1 MRPS11 MRPS12 MRPL3 MRPS24 | peptide metabolic process |
|   HPA:0320103 | 0.0305566096363 | 0.538461538462 | ZNF777 MRPS26 NOA1 MRPS6 MCAT AURKAIP1 MRPS11 | nasopharynx; respiratory epithelial cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
|  AURKAIP1 |  MRPS11 | 0.998 | 0.738           |          |
|  TRA2A |  MRPS11 | 0.998 | 0.08           |          |
|  TRA2A |  MRPS6 | 0.998 | 0.084           |          |
|  AURKAIP1 |  MRPS24 | 0.998 | 0.622666666667           |
structurally_consistent (dimer)        
|
|  MRPL3 |  MRPS6 | 0.996 | 0.826           |
structurally_consistent (Q5T653)        
|
|  NOA1 |  MRPS11 | 0.996 | 0.084           |          |
|  MRPS11 |  MRPS24 | 0.995 | 0.462           |
structurally_consistent (dimer)        
|
|  MRPS6 |  MCAT | 0.995 | 0.294           |
structurally_consistent (dimer)        
|
|  MRPS24 |  MRPS6 | 0.995 | 0.812           |
structurally_consistent (P82673)        
structurally_consistent (dimer)         |
|  MRPS26 |  MRPS11 | 0.993 | 0.748           |
structurally_consistent (dimer)        
|
|  AURKAIP1 |  MRPS26 | 0.993 | 0.641733990148           |          |
|  METTL17 |  MRPS6 | 0.992 | 0.404           |          |
|  MRPS11 |  MCAT | 0.992 | 0.174           |          |
|  MRPS26 |  MRPS6 | 0.991 | 0.906           |
structurally_consistent (dimer)        
|
|  MRPS26 |  MRPS24 | 0.99 | 0.692           |          |
|  MRPS11 |  MRPS6 | 0.988 | 0.902           |
structurally_consistent (Q9BYN8)        
|
|  TRA2A |  MRPS24 | 0.988 | 0.006           |
mutually_exclusive (P82673)        
|
|  AURKAIP1 |  MRPS6 | 0.988 | 0.73           |          |
|  MRPS24 |  MCAT | 0.986 | 0.178           |          |
|  METTL17 |  MCAT | 0.986 | 0.308           |          |
|  TRA2A |  MRPL3 | 0.984 | 0.106           |          |
|  AURKAIP1 |  METTL17 | 0.984 | 0.212           |          |
|  AURKAIP1 |  NOA1 | 0.983 | 0.088           |          |
|  NOA1 |  MCAT | 0.983 | 0.046           |          |
|  METTL17 |  MRPS26 | 0.979 | 0.42           |          |
|  MRPS26 |  MCAT | 0.979 | 0.222           |          |
|  NOA1 |  MRPS6 | 0.978 | 0.102           |          |
|  ZNF777 |  MRPS24 | 0.975 |            |          |
|  MRPS26 |  ZC3H3 | 0.974 | 0.166           |          |
|  MRPS26 |  MRPS12 | 0.974 | 0.693903225806           |          |
|  METTL17 |  MRPS11 | 0.974 | 0.3           |          |
|  MRPS26 |  NOA1 | 0.972 | 0.08           |          |
|  MRPS11 |  MRPS12 | 0.97 | 0.49           |          |
|  MRPS12 |  MRPS6 | 0.965 | 0.77           |          |
|  MRPL3 |  ZC3H3 | 0.964 | 0.128           |          |
|  NOA1 |  MRPS12 | 0.964 | 0.116           |          |
|  ZC3H3 |  MRPS6 | 0.962 | 0.158           |          |
|  NOA1 |  MRPS24 | 0.959 | 0.04           |          |
|  AURKAIP1 |  MRPS12 | 0.953 | 0.092           |          |
|  ZNF777 |  MRPS6 | 0.953 |            |          |
|  TRA2A |  MRPS26 | 0.951 | 0.08           |          |
|  METTL17 |  MRPS24 | 0.95 | 0.264           |          |
|  TRA2A |  NOA1 | 0.948 | 0.038           |          |
|  ZNF777 |  MRPS11 | 0.948 |            |          |
|  MRPL3 |  MRPS26 | 0.929 | 0.69           |          |
|  AURKAIP1 |  MCAT | 0.926 | 0.378           |
structurally_consistent (Q96EY7)        
|
|  MRPS12 |  MRPS24 | 0.923 | 0.674           |          |
|  MRPL3 |  MCAT | 0.912 | 0.136           |          |
|  MRPL3 |  MRPS24 | 0.866 | 0.37           |          |
|  MRPS12 |  MCAT | 0.835 | 0.058           |          |
|  MRPL3 |  MRPS11 | 0.831 | 0.416           |          |
|  METTL17 |  NOA1 | 0.814 | 0.072           |          |
|  TRA2A |  ZNF777 | 0.793 |            |          |
|  ZNF777 |  METTL17 | 0.773 |            |          |
|  ZNF777 |  MRPS26 | 0.761 |            |          |
|  METTL17 |  MRPS12 | 0.741 | 0.156           |          |
|  ZC3H3 |  MRPS24 | 0.721 | 0.156988372093           |          |
|  ZC3H3 |  MRPS11 | 0.718 | 0.138           |          |
|  TRA2A |  ZC3H3 | 0.7 | 0.144           |          |
|  MRPL3 |  AURKAIP1 | 0.697 | 0.382           |          |
|  MRPL3 |  ZNF777 | 0.651 |            |          |
|  MRPL3 |  NOA1 | 0.437 | 0.24           |          |
|  ZNF777 |  MRPS12 | 0.411 |            |          |
|  ZNF777 |  MCAT | 0.321 |            |          |
|  MRPL3 |  METTL17 | 0.312 | 0.536           |          |
|  ZNF777 |  NOA1 | 0.308 |            |          |
|  TRA2A |  MCAT | 0.227 | 0.048           |
mutually_exclusive (P82673)        
|
|  TRA2A |  METTL17 | 0.18 | 0.098           |          |
|  MRPL3 |  MRPS12 | 0.114 | 0.688           |          |
|  ZNF777 |  AURKAIP1 | 0.082 |            |          |
|  ZNF777 |  ZC3H3 | 0.061 |            |          |
|  ZC3H3 |  MRPS12 | 0.043 | 0.17           |          |
|  ZC3H3 |  MCAT | 0.035 | 0.208           |          |
|  TRA2A |  MRPS12 | 0.028 | 0.068           |          |
|  METTL17 |  ZC3H3 | 0.018 | 0.124           |          |
|  NOA1 |  ZC3H3 | 0.015 | 0.186           |          |
|  TRA2A |  AURKAIP1 | 0.006 | 0.198           |          |
Related Complexes