hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02378.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NDUFA2 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 (Complex I-B8) (CI-B8) (NADH-ubiquinone oxidoreductase B8 subunit) | 5 | UniProt NCBI |
| NDUFS6 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2920 | 0.000205051410255 | 1.0 | NDUFA2 NDUFS6 | Respiratory chain complex I (lambda subunit) mitochondrial |
| WP:WP4324 | 0.000632070972113 | 1.0 | NDUFA2 NDUFS6 | Mitochondrial complex I assembly model OXPHOS system |
| WP:WP623 | 0.000728264938239 | 1.0 | NDUFA2 NDUFS6 | Oxidative phosphorylation |
| KEGG:04723 | 0.0011414018249 | 1.0 | NDUFA2 NDUFS6 | Retrograde endocannabinoid signaling |
| KEGG:00190 | 0.00119992691491 | 1.0 | NDUFA2 NDUFS6 | Oxidative phosphorylation |
| CORUM:178 | 0.00154301186217 | 1.0 | NDUFA2 NDUFS6 | Respiratory chain complex I (holoenzyme), mitochondrial |
| KEGG:04932 | 0.00155920593969 | 1.0 | NDUFA2 NDUFS6 | Non-alcoholic fatty liver disease |
| WP:WP111 | 0.00202305274778 | 1.0 | NDUFA2 NDUFS6 | Electron transport chain OXPHOS system in mitochondria |
| KEGG:05415 | 0.00267768543767 | 1.0 | NDUFA2 NDUFS6 | Diabetic cardiomyopathy |
| REAC:R-HSA-6799198 | 0.0027271837564 | 1.0 | NDUFA2 NDUFS6 | Complex I biogenesis |
| KEGG:05208 | 0.0033003273675 | 1.0 | NDUFA2 NDUFS6 | Chemical carcinogenesis - reactive oxygen species |
| KEGG:04714 | 0.00339933231144 | 1.0 | NDUFA2 NDUFS6 | Thermogenesis |
| WP:WP4396 | 0.00396523446209 | 1.0 | NDUFA2 NDUFS6 | Nonalcoholic fatty liver disease |
| KEGG:05012 | 0.00458495309323 | 1.0 | NDUFA2 NDUFS6 | Parkinson disease |
| KEGG:05020 | 0.00485920816781 | 1.0 | NDUFA2 NDUFS6 | Prion disease |
| KEGG:05016 | 0.00594761227231 | 1.0 | NDUFA2 NDUFS6 | Huntington disease |
| REAC:R-HSA-611105 | 0.00828920325958 | 1.0 | NDUFA2 NDUFS6 | Respiratory electron transport |
| KEGG:05014 | 0.00850662183301 | 1.0 | NDUFA2 NDUFS6 | Amyotrophic lateral sclerosis |
| KEGG:05010 | 0.0093688914925 | 1.0 | NDUFA2 NDUFS6 | Alzheimer disease |
| REAC:R-HSA-163200 | 0.0124056103205 | 1.0 | NDUFA2 NDUFS6 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| HP:0011923 | 0.0133830220427 | 1.0 | NDUFA2 NDUFS6 | Decreased activity of mitochondrial complex I |
| KEGG:05022 | 0.0138982457502 | 1.0 | NDUFA2 NDUFS6 | Pathways of neurodegeneration - multiple diseases |
| REAC:R-HSA-1428517 | 0.0242575818332 | 1.0 | NDUFA2 NDUFS6 | The citric acid (TCA) cycle and respiratory electron transport |
| HP:0008972 | 0.0277776310426 | 1.0 | NDUFA2 NDUFS6 | Decreased activity of mitochondrial respiratory chain |
| HP:0011922 | 0.0295479082178 | 1.0 | NDUFA2 NDUFS6 | Abnormal activity of mitochondrial respiratory chain |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NDUFA2 | NDUFS6 | 1.0 | 0.986 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
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