hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02384.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PNKP | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] | 5 | UniProt NCBI |
| POLB | DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18) | 5 | UniProt NCBI |
| TDP1 | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) | 5 | UniProt NCBI |
| XRCC1 | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | 5 | UniProt NCBI |
| APLF | Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) | 5 | UniProt NCBI |
| APTX | Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | 5 | UniProt NCBI |
| LIG3 | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03410 | 5.3719390717e-11 | 0.833333333333 | TDP1 PNKP APTX LIG3 POLB | Base excision repair |
| CORUM:5243 | 4.67737426163e-09 | 0.5 | PNKP LIG3 TDP1 | XRCC1-LIG3-PNK-TDP1 complex |
| CORUM:362 | 4.67737426163e-09 | 0.5 | PNKP LIG3 POLB | DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex |
| REAC:R-HSA-5649702 | 2.47215416054e-07 | 0.5 | PNKP LIG3 POLB | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
| WP:WP4752 | 1.11514262748e-05 | 0.5 | PNKP LIG3 POLB | Base excision repair |
| REAC:R-HSA-73933 | 4.60302232639e-05 | 0.5 | PNKP LIG3 POLB | Resolution of Abasic Sites (AP sites) |
| GO:0006281 | 6.40006279167e-05 | 1.0 | PNKP APLF TDP1 POLB APTX LIG3 | DNA repair |
| CORUM:1085 | 0.000102488289015 | 0.333333333333 | POLB LIG3 | DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| CORUM:1086 | 0.000102488289015 | 0.333333333333 | POLB LIG3 | DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| GO:0140097 | 0.000113200789661 | 0.833333333333 | APTX POLB APLF LIG3 TDP1 | catalytic activity, acting on DNA |
| REAC:R-HSA-110381 | 0.000154862819062 | 0.333333333333 | POLB LIG3 | Resolution of AP sites via the single-nucleotide replacement pathway |
| GO:0000012 | 0.0002304395259 | 0.5 | TDP1 APLF APTX | single strand break repair |
| HP:0003380 | 0.000290543404042 | 0.5 | TDP1 LIG3 APTX | Decreased number of peripheral myelinated nerve fibers |
| REAC:R-HSA-73884 | 0.000491292751059 | 0.5 | PNKP LIG3 POLB | Base Excision Repair |
| REAC:R-HSA-73894 | 0.000502730176626 | 0.666666666667 | TDP1 PNKP LIG3 POLB | DNA Repair |
| GO:0006287 | 0.000548960443183 | 0.5 | PNKP LIG3 POLB | base-excision repair, gap-filling |
| GO:0006266 | 0.000548960443183 | 0.5 | PNKP APLF LIG3 | DNA ligation |
| GO:0006302 | 0.00061299016503 | 0.833333333333 | TDP1 PNKP APLF LIG3 POLB | double-strand break repair |
| WP:WP4946 | 0.000634899192361 | 0.5 | PNKP LIG3 POLB | DNA repair pathways full network |
| HP:0003431 | 0.000687513326152 | 0.5 | PNKP LIG3 TDP1 | Decreased motor nerve conduction velocity |
| GO:0006974 | 0.000689085771861 | 1.0 | PNKP APLF TDP1 POLB APTX LIG3 | DNA damage response |
| HP:0040131 | 0.000769715072349 | 0.5 | PNKP LIG3 TDP1 | Abnormal motor nerve conduction velocity |
| GO:0006259 | 0.00100146498641 | 1.0 | PNKP APLF TDP1 POLB APTX LIG3 | DNA metabolic process |
| HP:0003124 | 0.00100321433019 | 0.5 | APTX PNKP TDP1 | Hypercholesterolemia |
| HP:0007141 | 0.0026840867676 | 0.5 | PNKP LIG3 TDP1 | Sensorimotor neuropathy |
| HP:0003474 | 0.00371596358652 | 0.666666666667 | APTX PNKP LIG3 TDP1 | Somatic sensory dysfunction |
| HP:0003130 | 0.00378495258144 | 0.5 | TDP1 LIG3 APTX | Abnormal peripheral myelination |
| HP:0000762 | 0.00390912678804 | 0.5 | PNKP LIG3 TDP1 | Decreased nerve conduction velocity |
| HP:0003073 | 0.0042978003653 | 0.5 | APTX PNKP TDP1 | Hypoalbuminemia |
| HP:0012116 | 0.0042978003653 | 0.5 | APTX PNKP TDP1 | Abnormal circulating albumin concentration |
| HP:0040129 | 0.00443283482612 | 0.5 | PNKP LIG3 TDP1 | Abnormal nerve conduction velocity |
| HP:0002495 | 0.00530249442786 | 0.5 | APTX PNKP TDP1 | Impaired vibratory sensation |
| HP:0001272 | 0.0054109367211 | 0.666666666667 | APTX PNKP LIG3 TDP1 | Cerebellar atrophy |
| HP:0009830 | 0.00686692509015 | 0.666666666667 | APTX PNKP LIG3 TDP1 | Peripheral neuropathy |
| HP:0002936 | 0.0069909928987 | 0.5 | APTX PNKP TDP1 | Distal sensory impairment |
| HPA:0570792 | 0.00728091434471 | 0.833333333333 | TDP1 PNKP APTX LIG3 POLB | testis; round or early spermatids[>=Medium] |
| HP:0003134 | 0.0075592305979 | 0.5 | PNKP LIG3 TDP1 | Abnormality of peripheral nerve conduction |
| HP:0010831 | 0.00878583114312 | 0.5 | APTX PNKP TDP1 | Impaired proprioception |
| HP:0003107 | 0.00967270294092 | 0.5 | APTX PNKP TDP1 | Abnormal circulating cholesterol concentration |
| GO:0140640 | 0.0126169815669 | 0.833333333333 | APTX POLB APLF LIG3 TDP1 | catalytic activity, acting on a nucleic acid |
| HP:0030177 | 0.0129601794289 | 0.5 | PNKP LIG3 TDP1 | Abnormality of peripheral nervous system electrophysiology |
| HP:0032120 | 0.0138111776458 | 0.5 | PNKP LIG3 TDP1 | Abnormal peripheral nervous system physiology |
| HP:0003621 | 0.0149045236961 | 0.666666666667 | APTX PNKP LIG3 TDP1 | Juvenile onset |
| HP:0003387 | 0.0164828756284 | 0.333333333333 | APTX LIG3 | Decreased number of large peripheral myelinated nerve fibers |
| GO:0006284 | 0.0188853212627 | 0.5 | PNKP LIG3 POLB | base-excision repair |
| HPA:0570791 | 0.0193965540142 | 0.833333333333 | TDP1 PNKP APTX LIG3 POLB | testis; round or early spermatids[>=Low] |
| HP:0012447 | 0.0204888410025 | 0.666666666667 | APTX PNKP LIG3 TDP1 | Abnormal myelination |
| GO:0033554 | 0.0233939744337 | 1.0 | PNKP APLF TDP1 POLB APTX LIG3 | cellular response to stress |
| HP:0000764 | 0.0284303919892 | 0.5 | TDP1 LIG3 APTX | Peripheral axonal degeneration |
| WP:WP4016 | 0.0290813206156 | 0.333333333333 | POLB TDP1 | DNA IR damage and cellular response via ATR |
| HP:0003693 | 0.0308282983803 | 0.5 | APTX PNKP TDP1 | Distal amyotrophy |
| HP:0002460 | 0.0354738812843 | 0.5 | PNKP LIG3 TDP1 | Distal muscle weakness |
| GO:0051103 | 0.042122686785 | 0.333333333333 | PNKP LIG3 | DNA ligation involved in DNA repair |
| GO:0006303 | 0.0421653429605 | 0.5 | PNKP APLF POLB | double-strand break repair via nonhomologous end joining |
| CORUM:363 | 0.0499436884912 | 0.166666666667 | LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:365 | 0.0499436884912 | 0.166666666667 | LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:212 | 0.0499436884912 | 0.166666666667 | LIG3 | DNA ligase III-XRCC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LIG3 | XRCC1 | 1.0 | 0.55 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| POLB | XRCC1 | 0.999 | 0.084 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| LIG3 | POLB | 0.999 | 0.1 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| LIG3 | PNKP | 0.998 | 0.18 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| LIG3 | APTX | 0.997 | 0.136 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| APLF | LIG3 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LIG3 | TDP1 | 0.996 | 0.0660385964912 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PNKP | POLB | 0.994 | 0.108 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PNKP | XRCC1 | 0.993 | 0.13 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| APLF | POLB | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| APLF | XRCC1 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| POLB | APTX | 0.99 | 0.134 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| POLB | TDP1 | 0.986 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PNKP | APTX | 0.958 | 0.13 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| XRCC1 | APTX | 0.951 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| XRCC1 | TDP1 | 0.918 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only |
| APLF | TDP1 | 0.904 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PNKP | TDP1 | 0.862 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only |
| TDP1 | APTX | 0.765 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only |
| APLF | APTX | 0.353 | bioplex_WMM bioplex3_WMM WMM_only | |
| APLF | PNKP | 0.297 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes