hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02424.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK) | 5 | UniProt NCBI |
| IKBKG | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3849 | 2.8092043205e-05 | 1.0 | MAP3K14 IKBKG | MAPK and NFkB signaling pathways inhibited by Yersinia YopJ |
| CORUM:5194 | 7.68942788458e-05 | 1.0 | MAP3K14 IKBKG | TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) |
| WP:WP262 | 9.83221512175e-05 | 1.0 | MAP3K14 IKBKG | Ebstein Barr virus LMP1 signaling |
| CORUM:5266 | 0.000133283416666 | 1.0 | MAP3K14 IKBKG | TNF-alpha/NF-kappa B signaling complex 6 |
| WP:WP2112 | 0.000160890792901 | 1.0 | MAP3K14 IKBKG | IL 17 signaling pathway |
| KEGG:05120 | 0.000317498613307 | 1.0 | MAP3K14 IKBKG | Epithelial cell signaling in Helicobacter pylori infection |
| WP:WP2795 | 0.00036647347272 | 1.0 | MAP3K14 IKBKG | Cardiac hypertrophic response |
| WP:WP195 | 0.000480118556595 | 1.0 | MAP3K14 IKBKG | IL 1 signaling pathway |
| WP:WP3863 | 0.000500549133471 | 1.0 | MAP3K14 IKBKG | T cell antigen receptor TCR pathway during Staphylococcus aureus infection |
| KEGG:04064 | 0.000513720234536 | 1.0 | MAP3K14 IKBKG | NF-kappa B signaling pathway |
| KEGG:04625 | 0.00058037380927 | 1.0 | MAP3K14 IKBKG | C-type lectin receptor signaling pathway |
| WP:WP5072 | 0.000586527811159 | 1.0 | MAP3K14 IKBKG | Modulators of TCR signaling and T cell activation |
| KEGG:04668 | 0.000725873685824 | 1.0 | MAP3K14 IKBKG | TNF signaling pathway |
| WP:WP69 | 0.000778915743411 | 1.0 | MAP3K14 IKBKG | T cell receptor signaling pathway |
| KEGG:04660 | 0.000853978605069 | 1.0 | MAP3K14 IKBKG | T cell receptor signaling pathway |
| WP:WP1544 | 0.000998544444832 | 1.0 | MAP3K14 IKBKG | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04380 | 0.00106564434727 | 1.0 | MAP3K14 IKBKG | Osteoclast differentiation |
| KEGG:04210 | 0.00116074761854 | 1.0 | MAP3K14 IKBKG | Apoptosis |
| KEGG:04936 | 0.00123975649005 | 1.0 | MAP3K14 IKBKG | Alcoholic liver disease |
| WP:WP231 | 0.00148377064565 | 1.0 | MAP3K14 IKBKG | TNF alpha signaling pathway |
| KEGG:05169 | 0.00261899777797 | 1.0 | MAP3K14 IKBKG | Epstein-Barr virus infection |
| KEGG:05166 | 0.00317059675131 | 1.0 | MAP3K14 IKBKG | Human T-cell leukemia virus 1 infection |
| KEGG:05208 | 0.0033003273675 | 1.0 | MAP3K14 IKBKG | Chemical carcinogenesis - reactive oxygen species |
| KEGG:04010 | 0.0047800367266 | 1.0 | MAP3K14 IKBKG | MAPK signaling pathway |
| REAC:R-HSA-5607764 | 0.00684359081728 | 1.0 | MAP3K14 IKBKG | CLEC7A (Dectin-1) signaling |
| WP:WP382 | 0.00855530406698 | 1.0 | MAP3K14 IKBKG | MAPK signaling pathway |
| REAC:R-HSA-5621481 | 0.0122005589102 | 1.0 | MAP3K14 IKBKG | C-type lectin receptors (CLRs) |
| CORUM:5827 | 0.0249718442457 | 0.5 | IKBKG | IKBKG homotetramer complex |
| CORUM:2123 | 0.0249718442457 | 0.5 | IKBKG | IKBKG homodimer complex |
| CORUM:5730 | 0.0249718442457 | 0.5 | IKBKG | IKBKG homotrimer complex |
| WP:WP4479 | 0.0435328773163 | 0.5 | IKBKG | Supression of HMGB1 mediated inflammation by THBD |
| WP:WP4480 | 0.049750157242 | 0.5 | IKBKG | Altered glycosylation of MUC1 in tumor microenvironment |
| WP:WP4562 | 0.049750157242 | 0.5 | IKBKG | Canonical NF kB pathway |
| CORUM:5829 | 0.0499419797295 | 0.5 | IKBKG | IKBKG-CHUK complex |
| CORUM:5828 | 0.0499419797295 | 0.5 | IKBKG | IKBKG-IKBKB complex |
| CORUM:4043 | 0.0499419797295 | 0.5 | IKBKG | NEMO-HIF2(alpha)-ARNT complex |
| CORUM:2104 | 0.0499419797295 | 0.5 | MAP3K14 | IKKB-NIK complex |
| CORUM:6152 | 0.0499419797295 | 0.5 | IKBKG | IKBKG-CHUK complex |
| HP:0012121 | 0.0499436884913 | 0.5 | IKBKG | Panuveitis |
| HP:0040042 | 0.0499436884913 | 0.5 | IKBKG | Aplasia of the eccrine sweat glands |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAP3K14 | IKBKG | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
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