hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02425.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDE4D | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | 5 | UniProt NCBI |
| PDE4A | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | 5 | UniProt NCBI |
| PDE4B | 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5294 | 7.51131611315e-08 | 1.0 | PDE4B PDE4D PDE4A | Sildenafil treatment |
| WP:WP4222 | 6.53926343968e-07 | 1.0 | PDE4B PDE4D PDE4A | Phosphodiesterases in neuronal function |
| KEGG:05032 | 2.61801737967e-06 | 1.0 | PDE4B PDE4D PDE4A | Morphine addiction |
| KEGG:04928 | 4.79978559464e-06 | 1.0 | PDE4B PDE4D PDE4A | Parathyroid hormone synthesis, secretion and action |
| WP:WP35 | 5.89711955236e-06 | 1.0 | PDE4B PDE4D PDE4A | G protein signaling pathways |
| KEGG:00230 | 7.94536617802e-06 | 1.0 | PDE4B PDE4D PDE4A | Purine metabolism |
| GO:0030552 | 1.58598067776e-05 | 1.0 | PDE4B PDE4D PDE4A | cAMP binding |
| GO:0004115 | 2.11464090368e-05 | 1.0 | PDE4B PDE4D PDE4A | 3',5'-cyclic-AMP phosphodiesterase activity |
| KEGG:04024 | 3.36919550068e-05 | 1.0 | PDE4B PDE4D PDE4A | cAMP signaling pathway |
| GO:0004114 | 6.5361627932e-05 | 1.0 | PDE4B PDE4D PDE4A | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| GO:0004112 | 7.84339535184e-05 | 1.0 | PDE4B PDE4D PDE4A | cyclic-nucleotide phosphodiesterase activity |
| GO:0030551 | 7.84339535184e-05 | 1.0 | PDE4B PDE4D PDE4A | cyclic nucleotide binding |
| REAC:R-HSA-180024 | 0.00129444299395 | 0.666666666667 | PDE4D PDE4A | DARPP-32 events |
| GO:1901898 | 0.00140460216025 | 0.666666666667 | PDE4D PDE4B | negative regulation of relaxation of cardiac muscle |
| GO:0008081 | 0.00328922780564 | 1.0 | PDE4B PDE4D PDE4A | phosphoric diester hydrolase activity |
| WP:WP289 | 0.00958854810456 | 0.666666666667 | PDE4D PDE4B | Myometrial relaxation and contraction pathways |
| GO:1901897 | 0.0140440992017 | 0.666666666667 | PDE4D PDE4B | regulation of relaxation of cardiac muscle |
| GO:1901078 | 0.0140440992017 | 0.666666666667 | PDE4D PDE4B | negative regulation of relaxation of muscle |
| KEGG:01100 | 0.0189521995452 | 1.0 | PDE4B PDE4D PDE4A | Metabolic pathways |
| REAC:R-HSA-111885 | 0.0204048321881 | 0.666666666667 | PDE4D PDE4A | Opioid Signalling |
| REAC:R-HSA-418555 | 0.0284248695791 | 0.666666666667 | PDE4D PDE4A | G alpha (s) signalling events |
| GO:0071872 | 0.0393180950424 | 0.666666666667 | PDE4D PDE4B | cellular response to epinephrine stimulus |
| GO:0071871 | 0.0393180950424 | 0.666666666667 | PDE4D PDE4B | response to epinephrine |
| CORUM:518 | 0.0499402709677 | 0.333333333333 | PDE4D | AKAP250-PKA-PDE4D complex |
| CORUM:6046 | 0.0499402709677 | 0.333333333333 | PDE4B | PDE4B-DISC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PDE4D | PDE4B | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PDE4D | PDE4A | 0.997 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PDE4A | PDE4B | 0.688 | bioplex3_WMM WMM_only |
Related Complexes