hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02456.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GUCY1A2 | Guanylate cyclase soluble subunit alpha-2 (GCS-alpha-2) (EC 4.6.1.2) | 5 | UniProt NCBI |
| GUCY1A1 | Guanylate cyclase soluble subunit alpha-1 (GCS-alpha-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit alpha-3) (GCS-alpha-3) (Soluble guanylate cyclase large subunit) | 5 | UniProt NCBI |
| GUCY1B1 | Guanylate cyclase soluble subunit beta-1 (GCS-beta-1) (EC 4.6.1.2) (Guanylate cyclase soluble subunit beta-3) (GCS-beta-3) (Soluble guanylate cyclase small subunit) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:408 | 1.70876175213e-06 | 1.0 | GUCY1A1 GUCY1B1 | Guanylyl cyclase, soluble (GUCY1A3, GUCY1B3) |
| WP:WP5294 | 7.2783930122e-05 | 1.0 | GUCY1A1 GUCY1B1 | Sildenafil treatment |
| WP:WP5113 | 0.000138332030934 | 1.0 | GUCY1A1 GUCY1B1 | Antiviral and anti inflammatory effects of Nrf2 on SARS CoV 2 pathway |
| KEGG:04924 | 0.000183378615366 | 1.0 | GUCY1A1 GUCY1B1 | Renin secretion |
| KEGG:04730 | 0.000183378615366 | 1.0 | GUCY1A1 GUCY1B1 | Long-term depression |
| REAC:R-HSA-392154 | 0.00023239159829 | 1.0 | GUCY1A1 GUCY1B1 | Nitric oxide stimulates guanylate cyclase |
| WP:WP4008 | 0.00028347425416 | 1.0 | GUCY1A1 GUCY1B1 | NO cGMP PKG mediated neuroprotection |
| WP:WP4222 | 0.000299222823835 | 1.0 | GUCY1A1 GUCY1B1 | Phosphodiesterases in neuronal function |
| KEGG:04970 | 0.000327740504058 | 1.0 | GUCY1A1 GUCY1B1 | Salivary secretion |
| KEGG:04540 | 0.000403985690766 | 1.0 | GUCY1A1 GUCY1B1 | Gap junction |
| KEGG:04713 | 0.000427233157076 | 1.0 | GUCY1A1 GUCY1B1 | Circadian entrainment |
| KEGG:04270 | 0.000741317806799 | 1.0 | GUCY1A1 GUCY1B1 | Vascular smooth muscle contraction |
| KEGG:04611 | 0.000772693757832 | 1.0 | GUCY1A1 GUCY1B1 | Platelet activation |
| KEGG:00230 | 0.000772693757832 | 1.0 | GUCY1A1 GUCY1B1 | Purine metabolism |
| KEGG:04921 | 0.00112221860095 | 1.0 | GUCY1A1 GUCY1B1 | Oxytocin signaling pathway |
| REAC:R-HSA-445355 | 0.00113803532692 | 1.0 | GUCY1A1 GUCY1B1 | Smooth Muscle Contraction |
| KEGG:04022 | 0.00125991513217 | 1.0 | GUCY1A1 GUCY1B1 | cGMP-PKG signaling pathway |
| GO:0008074 | 0.00140460216025 | 1.0 | GUCY1A1 GUCY1B1 | guanylate cyclase complex, soluble |
| GO:0038060 | 0.00140460216025 | 1.0 | GUCY1A1 GUCY1B1 | nitric oxide-cGMP-mediated signaling pathway |
| REAC:R-HSA-418346 | 0.00436759503844 | 1.0 | GUCY1A1 GUCY1B1 | Platelet homeostasis |
| GO:0004383 | 0.00702301080125 | 1.0 | GUCY1A1 GUCY1B1 | guanylate cyclase activity |
| GO:0006182 | 0.00983221512175 | 1.0 | GUCY1A1 GUCY1B1 | cGMP biosynthetic process |
| GO:0046068 | 0.016855225923 | 1.0 | GUCY1A1 GUCY1B1 | cGMP metabolic process |
| REAC:R-HSA-397014 | 0.01909541258 | 1.0 | GUCY1A1 GUCY1B1 | Muscle contraction |
| CORUM:407 | 0.0249718442457 | 0.5 | GUCY1B1 | Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3) |
| GO:0009190 | 0.0365196561665 | 1.0 | GUCY1A1 GUCY1B1 | cyclic nucleotide biosynthetic process |
| GO:0016849 | 0.0491610756088 | 1.0 | GUCY1A1 GUCY1B1 | phosphorus-oxygen lyase activity |
| GO:0009975 | 0.0491610756088 | 1.0 | GUCY1A1 GUCY1B1 | cyclase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GUCY1A2 | GUCY1B1 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GUCY1A1 | GUCY1B1 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| GUCY1A2 | GUCY1A1 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes