hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02458.1

Complex Portal: CPX-19252

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
WASHC2C	WASH complex subunit 2C (Vaccinia virus penetration factor) (VPEF)	5	UniProt NCBI
CRACD	Capping protein-inhibiting regulator of actin dynamics (Cancer-related regulator of actin dynamics)	5	UniProt NCBI
RCSD1	CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1)	5	UniProt NCBI
CARMIL2	Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker 2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein)	5	UniProt NCBI
CAPZA1	F-actin-capping protein subunit alpha-1 (CapZ alpha-1)	5	UniProt NCBI
CPVL	Probable serine carboxypeptidase CPVL (EC 3.4.16.-) (Carboxypeptidase, vitellogenic-like) (Vitellogenic carboxypeptidase-like protein) (VCP-like protein) (hVLP)	4	UniProt NCBI
CAPZB	F-actin-capping protein subunit beta (CapZ beta)	5	UniProt NCBI
KIAA1671	Uncharacterized protein KIAA1671	2	UniProt NCBI
CAPZA2	F-actin-capping protein subunit alpha-2 (CapZ alpha-2)	5	UniProt NCBI
PLEKHO1	Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0051693	5.77241464357e-11	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	actin filament capping
GO:0051016	5.77241464357e-11	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	barbed-end actin filament capping
GO:0030835	1.36916403995e-10	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	negative regulation of actin filament depolymerization
GO:0030834	6.99427541614e-10	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of actin filament depolymerization
GO:0030837	1.79223373282e-09	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	negative regulation of actin filament polymerization
GO:0030042	1.79223373282e-09	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	actin filament depolymerization
GO:1901880	6.26742705426e-09	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	negative regulation of protein depolymerization
GO:0032272	9.43597092401e-09	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	negative regulation of protein polymerization
GO:0043242	2.22544333765e-08	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	negative regulation of protein-containing complex disassembly
GO:1901879	2.49190999624e-08	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of protein depolymerization
GO:0030833	1.53850929515e-07	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of actin filament polymerization
GO:0051261	2.67103933926e-07	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	protein depolymerization
GO:0008064	4.12801644775e-07	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of actin polymerization or depolymerization
GO:0043244	4.42538373683e-07	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of protein-containing complex disassembly
GO:0030832	5.07378211117e-07	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of actin filament length
CORUM:6484	5.88502576438e-07	0.3	CAPZB WASHC2C CAPZA1	WASH-CAPZalpa/beta complex
GO:0031333	6.19330980606e-07	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	negative regulation of protein-containing complex assembly
GO:0030041	7.9991521371e-07	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	actin filament polymerization
GO:0051494	1.45073794148e-06	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	negative regulation of cytoskeleton organization
GO:1902904	1.53488461042e-06	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	negative regulation of supramolecular fiber organization
GO:0008154	2.76144951612e-06	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	actin polymerization or depolymerization
GO:0071203	3.93917350423e-06	0.4	CAPZA1 WASHC2C CAPZB RCSD1	WASH complex
GO:0032271	5.16762668501e-06	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of protein polymerization
CORUM:6483	3.07577115383e-05	0.2	CAPZB CAPZA1	CAPZalpha-CAPZbeta complex
GO:0110053	3.23660665464e-05	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of actin filament organization
GO:2000813	4.61210427592e-05	0.3	CARMIL2 WASHC2C CRACD	negative regulation of barbed-end actin filament capping
GO:0032984	5.41199402069e-05	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	protein-containing complex disassembly
GO:0051258	6.11316447202e-05	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	protein polymerization
GO:0032535	7.97011535611e-05	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of cellular component size
GO:2000812	0.000115261178119	0.3	CARMIL2 WASHC2C CRACD	regulation of barbed-end actin filament capping
GO:0032956	0.000149377418575	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of actin cytoskeleton organization
GO:0032970	0.000289293396564	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of actin filament-based process
GO:0090066	0.000296056621564	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of anatomical structure size
GO:0010639	0.000347171973776	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	negative regulation of organelle organization
GO:1902903	0.000363051176943	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of supramolecular fiber organization
GO:0008290	0.00040312426486	0.3	CAPZB CAPZA1 CAPZA2	F-actin capping protein complex
GO:0043254	0.000557788853723	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of protein-containing complex assembly
KEGG:04144	0.000596735285093	0.4	CAPZA2 CAPZB WASHC2C CAPZA1	Endocytosis
CORUM:846	0.000859331699025	0.2	CAPZB CAPZA1	RICH1/AMOT polarity complex, Flag-Rich1 precipitated
REAC:R-HSA-6811436	0.00107384244619	0.3	CAPZB CAPZA1 CAPZA2	COPI-independent Golgi-to-ER retrograde traffic
REAC:R-HSA-9662360	0.00114054706802	0.3	CAPZB CAPZA1 CAPZA2	Sensory processing of sound by inner hair cells of the cochlea
REAC:R-HSA-3371497	0.00120994095815	0.3	CAPZB CAPZA1 CAPZA2	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
GO:0030836	0.00138065085968	0.3	CARMIL2 WASHC2C CRACD	positive regulation of actin filament depolymerization
GO:0007015	0.00139680063579	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	actin filament organization
REAC:R-HSA-9659379	0.00143477582929	0.3	CAPZB CAPZA1 CAPZA2	Sensory processing of sound
CORUM:6671	0.00238948713682	0.2	CAPZB CAPZA1	PI4K2A-WASH complex
GO:0051493	0.00276797925936	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	regulation of cytoskeleton organization
GO:1901881	0.00328700479383	0.3	CARMIL2 WASHC2C CRACD	positive regulation of protein depolymerization
GO:0022411	0.00423303735962	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	cellular component disassembly
REAC:R-HSA-879415	0.00456686801865	0.2	CAPZA1 CAPZA2	Advanced glycosylation endproduct receptor signaling
KEGG:04814	0.00762923053273	0.3	CAPZB CAPZA1 CAPZA2	Motor proteins
REAC:R-HSA-6807878	0.00769948216088	0.3	CAPZB CAPZA1 CAPZA2	COPI-mediated anterograde transport
GO:0051129	0.0125941137949	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	negative regulation of cellular component organization
REAC:R-HSA-2132295	0.0139121018372	0.3	CAPZB CAPZA1 CAPZA2	MHC class II antigen presentation
REAC:R-HSA-8856688	0.0173517632316	0.3	CAPZB CAPZA1 CAPZA2	Golgi-to-ER retrograde transport
GO:0030036	0.0207394393406	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	actin cytoskeleton organization
REAC:R-HSA-199977	0.0252825613706	0.3	CAPZB CAPZA1 CAPZA2	ER to Golgi Anterograde Transport
REAC:R-HSA-983231	0.0333532977065	0.3	CAPZB CAPZA1 CAPZA2	Factors involved in megakaryocyte development and platelet production
GO:0043243	0.033448305627	0.3	CARMIL2 WASHC2C CRACD	positive regulation of protein-containing complex disassembly
GO:0030029	0.0393567503283	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	actin filament-based process
REAC:R-HSA-948021	0.0436921850818	0.3	CAPZB CAPZA1 CAPZA2	Transport to the Golgi and subsequent modification
GO:0097435	0.0447187351818	0.6	CAPZA1 CAPZB WASHC2C CRACD CARMIL2 CAPZA2	supramolecular fiber organization
CORUM:7002	0.0499436884912	0.1	CAPZB	CAPZA3-CAPZB complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
CAPZA1	CAPZB	1.0	0.946	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM
CAPZB	PLEKHO1	1.0	0.126		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
WASHC2C	CAPZA2	1.0	0.094		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
CAPZB	CAPZA2	1.0	0.934	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM
CAPZA1	PLEKHO1	0.999	0.086	mutually_exclusive (P47755) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CAPZA1	CAPZA2	0.999	0.72	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM boldt_WMM
CRACD	CAPZB	0.999	0.242		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
CARMIL2	CAPZB	0.998	0.18		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
KIAA1671	CAPZA2	0.998	0.108	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM
CARMIL2	CAPZA2	0.998	0.09	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
CRACD	CAPZA1	0.998	0.174	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
CARMIL2	CAPZA1	0.998	0.082	mutually_exclusive (P47755)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only
RCSD1	CAPZA2	0.997	0.118	mutually_exclusive (P52907) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CPVL	CAPZB	0.997	0.144		bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only
CPVL	CAPZA2	0.997	0.168	mutually_exclusive (O00399)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM
CRACD	CAPZA2	0.997	0.252	mutually_exclusive (P52907) structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM
WASHC2C	CAPZB	0.997	0.208		hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only
RCSD1	CAPZB	0.997	0.052		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CAPZA2	PLEKHO1	0.997	0.08	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CAPZA1	CPVL	0.996	0.104		bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only
RCSD1	CAPZA1	0.996	0.06	mutually_exclusive (P47755) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CAPZB	KIAA1671	0.994	0.228	mutually_exclusive (P47755)	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
CAPZA1	KIAA1671	0.993	0.096	mutually_exclusive (P47755)	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only
WASHC2C	CAPZA1	0.99	0.173050905953		bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM boldt_WMM WMM_only
WASHC2C	CRACD	0.972	0.11		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
CRACD	CPVL	0.967	0.142		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only
CRACD	CARMIL2	0.964	0.076		bioplex_WMM bioplex3_WMM WMM_only
CRACD	KIAA1671	0.958	0.042	mutually_exclusive (P47755)	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
WASHC2C	CARMIL2	0.95	0.028		bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
WASHC2C	KIAA1671	0.935	0.096		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
CARMIL2	KIAA1671	0.864	0.04	mutually_exclusive (P47755)	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
CPVL	PLEKHO1	0.834	0.104		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
KIAA1671	PLEKHO1	0.766	0.074	mutually_exclusive (P47755)	bioplex_WMM bioplex3_WMM WMM_only
WASHC2C	CPVL	0.67	0.068		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
CRACD	PLEKHO1	0.629	0.102		bioplex_WMM bioplex3_WMM WMM_only
CARMIL2	PLEKHO1	0.629	0.124		bioplex_WMM bioplex3_WMM WMM_only
CARMIL2	CPVL	0.603	0.072		bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
WASHC2C	PLEKHO1	0.594	0.104		bioplex_WMM bioplex3_WMM WMM_only
CPVL	KIAA1671	0.203	0.042		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only

Related Complexes

Genename	Complexes
WASHC2C	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
CRACD	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
RCSD1	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
CARMIL2	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
CAPZA1	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
CPVL	huMAP3_02458.1 huMAP3_02470.1 huMAP3_04946.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_09952.1 huMAP3_10870.1 huMAP3_11730.1 huMAP3_12900.1
CAPZB	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
KIAA1671	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12900.1
CAPZA2	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_09348.1 huMAP3_10870.1 huMAP3_12900.1
PLEKHO1	huMAP3_02458.1 huMAP3_06652.1 huMAP3_08077.1 huMAP3_10870.1 huMAP3_12723.1 huMAP3_12900.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_02458.1

Complex Portal: CPX-19252