hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02461.1
Complex Portal: CPX-15987
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KIFAP3 | Kinesin-associated protein 3 (KAP-3) (KAP3) (Smg GDS-associated protein) | 5 | UniProt NCBI |
| KIF3C | Kinesin-like protein KIF3C | 5 | UniProt NCBI |
| NCKAP5 | Nck-associated protein 5 (NAP-5) (Peripheral clock protein) | 4 | UniProt NCBI |
| KIF3B | Kinesin-like protein KIF3B (HH0048) (Microtubule plus end-directed kinesin motor 3B) [Cleaved into: Kinesin-like protein KIF3B, N-terminally processed] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5620924 | 2.91499008839e-05 | 0.75 | KIF3C KIFAP3 KIF3B | Intraflagellar transport |
| REAC:R-HSA-983189 | 3.47141671819e-05 | 0.75 | KIF3C KIFAP3 KIF3B | Kinesins |
| REAC:R-HSA-6811434 | 0.000181248084935 | 0.75 | KIF3C KIFAP3 KIF3B | COPI-dependent Golgi-to-ER retrograde traffic |
| KEGG:04814 | 0.000236813619879 | 0.75 | KIF3C KIFAP3 KIF3B | Motor proteins |
| REAC:R-HSA-2132295 | 0.000362881762367 | 0.75 | KIF3C KIFAP3 KIF3B | MHC class II antigen presentation |
| REAC:R-HSA-8856688 | 0.000453862022785 | 0.75 | KIF3C KIFAP3 KIF3B | Golgi-to-ER retrograde transport |
| REAC:R-HSA-983231 | 0.000880808650283 | 0.75 | KIF3C KIFAP3 KIF3B | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-5617833 | 0.00153910156762 | 0.75 | KIF3C KIFAP3 KIF3B | Cilium Assembly |
| REAC:R-HSA-6811442 | 0.00163910921321 | 0.75 | KIF3C KIFAP3 KIF3B | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0005871 | 0.00298219742351 | 0.75 | KIF3C KIFAP3 KIF3B | kinesin complex |
| REAC:R-HSA-1852241 | 0.00474364374959 | 0.75 | KIF3C KIFAP3 KIF3B | Organelle biogenesis and maintenance |
| GO:0097542 | 0.00544401218013 | 0.75 | KIF3C KIFAP3 KIF3B | ciliary tip |
| GO:0005874 | 0.00586958333309 | 1.0 | KIF3C KIF3B KIFAP3 NCKAP5 | microtubule |
| GO:0016939 | 0.00842684400117 | 0.5 | KIFAP3 KIF3B | kinesin II complex |
| WP:WP4536 | 0.0120322522645 | 0.5 | KIFAP3 KIF3B | Genes related to primary cilium development based on CRISPR |
| REAC:R-HSA-1445148 | 0.0239057396727 | 0.5 | KIFAP3 KIF3B | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| GO:0072383 | 0.0280843539964 | 0.5 | KIFAP3 KIF3B | plus-end-directed vesicle transport along microtubule |
| REAC:R-HSA-109582 | 0.0327468558633 | 0.75 | KIF3C KIFAP3 KIF3B | Hemostasis |
| GO:0099513 | 0.0333098536164 | 1.0 | KIF3C KIF3B KIFAP3 NCKAP5 | polymeric cytoskeletal fiber |
| GO:0072386 | 0.042122686785 | 0.5 | KIFAP3 KIF3B | plus-end-directed organelle transport along microtubule |
| REAC:R-HSA-199991 | 0.0424877030349 | 0.75 | KIF3C KIFAP3 KIF3B | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0499402458571 | 0.75 | KIF3C KIFAP3 KIF3B | Vesicle-mediated transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| KIFAP3 | KIF3B | 1.0 | 0.376 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| KIFAP3 | KIF3C | 0.997 | 0.116 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| KIF3C | KIF3B | 0.983 | 0.178 |
mutually_exclusive (Q92845)
|
bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| KIFAP3 | NCKAP5 | 0.972 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| KIF3C | NCKAP5 | 0.972 |
mutually_exclusive (Q92845)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| NCKAP5 | KIF3B | 0.884 |
mutually_exclusive (Q92845)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes