hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02464.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PHC2 | Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2) | 5 | UniProt NCBI |
| RNF2 | E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2) | 5 | UniProt NCBI |
| CBX8 | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | 5 | UniProt NCBI |
| PHC3 | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | 5 | UniProt NCBI |
| BCOR | BCL-6 corepressor (BCoR) | 5 | UniProt NCBI |
| CBX4 | E3 SUMO-protein ligase CBX4 (EC 2.3.2.-) (Chromobox protein homolog 4) (Polycomb 2 homolog) (Pc2) (hPc2) | 5 | UniProt NCBI |
| CBX7 | Chromobox protein homolog 7 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03083 | 6.43130579194e-15 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | Polycomb repressive complex |
| GO:0000152 | 6.78992320207e-14 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | nuclear ubiquitin ligase complex |
| CORUM:115 | 1.82256396553e-13 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| CORUM:116 | 1.82256396553e-13 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| GO:0035102 | 2.07167961615e-13 | 0.857142857143 | RNF2 CBX8 PHC3 PHC2 CBX7 CBX4 | PRC1 complex |
| REAC:R-HSA-4655427 | 2.19843524306e-12 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | SUMOylation of DNA methylation proteins |
| GO:0031519 | 1.35501997046e-10 | 0.857142857143 | RNF2 CBX8 PHC3 PHC2 CBX7 CBX4 | PcG protein complex |
| REAC:R-HSA-8939243 | 2.75327037387e-10 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| REAC:R-HSA-3899300 | 3.66497485291e-10 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | SUMOylation of transcription cofactors |
| REAC:R-HSA-4570464 | 7.02448042352e-10 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-8943724 | 3.050618152e-09 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | Regulation of PTEN gene transcription |
| REAC:R-HSA-4551638 | 6.50451399979e-09 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-3108214 | 9.47078429583e-09 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | SUMOylation of DNA damage response and repair proteins |
| GO:0000151 | 4.18071769705e-08 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | ubiquitin ligase complex |
| REAC:R-HSA-2559580 | 7.70112750807e-08 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-6807070 | 2.50347940837e-07 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | PTEN Regulation |
| REAC:R-HSA-3108232 | 5.54362467035e-07 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 6.48717761862e-07 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | SUMOylation |
| REAC:R-HSA-2559583 | 9.28043128936e-07 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | Cellular Senescence |
| REAC:R-HSA-8878171 | 2.37842546682e-06 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-1257604 | 3.66680296363e-06 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | PIP3 activates AKT signaling |
| REAC:R-HSA-9006925 | 7.45838493156e-06 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | Intracellular signaling by second messengers |
| GO:1990234 | 5.8503111345e-05 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | transferase complex |
| GO:0140535 | 8.76375670222e-05 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | intracellular protein-containing complex |
| CORUM:1462 | 0.000123103089524 | 0.285714285714 | RNF2 PHC2 | hPRC1L complex |
| GO:0045892 | 0.000124321163524 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | negative regulation of DNA-templated transcription |
| GO:1902679 | 0.000134775138378 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | negative regulation of RNA biosynthetic process |
| GO:0051253 | 0.000268053401307 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | negative regulation of RNA metabolic process |
| CORUM:1178 | 0.000430566012817 | 0.285714285714 | RNF2 BCOR | BCOR complex |
| GO:0045934 | 0.000542735729451 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | negative regulation of nucleobase-containing compound metabolic process |
| GO:0140513 | 0.000698274170384 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | nuclear protein-containing complex |
| REAC:R-HSA-2262752 | 0.00109457503326 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.0011477966594 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | Cellular responses to stimuli |
| GO:0010558 | 0.00589550247442 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | negative regulation of macromolecule biosynthetic process |
| REAC:R-HSA-212436 | 0.00607059142443 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | Generic Transcription Pathway |
| GO:1902494 | 0.00674355151363 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | catalytic complex |
| GO:0031327 | 0.00689985249368 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | negative regulation of cellular biosynthetic process |
| GO:0051172 | 0.0071563927307 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | negative regulation of nitrogen compound metabolic process |
| GO:0009890 | 0.00718902774641 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | negative regulation of biosynthetic process |
| WP:WP4553 | 0.00877446561805 | 0.285714285714 | RNF2 BCOR | FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma |
| REAC:R-HSA-73857 | 0.0103732213005 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | RNA Polymerase II Transcription |
| CORUM:929 | 0.0114316030043 | 0.285714285714 | RNF2 CBX8 | CEN complex |
| REAC:R-HSA-597592 | 0.0148745508598 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | Post-translational protein modification |
| REAC:R-HSA-74160 | 0.0190899982826 | 0.714285714286 | PHC3 RNF2 CBX4 PHC2 CBX8 | Gene expression (Transcription) |
| REAC:R-HSA-8953750 | 0.0212237900738 | 0.285714285714 | RNF2 PHC3 | Transcriptional Regulation by E2F6 |
| GO:0031324 | 0.02453555576 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | negative regulation of cellular metabolic process |
| GO:0010605 | 0.028006946198 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | negative regulation of macromolecule metabolic process |
| GO:0009892 | 0.0484133454299 | 1.0 | RNF2 CBX8 PHC3 BCOR PHC2 CBX7 CBX4 | negative regulation of metabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PHC2 | CBX8 | 1.0 | 0.262 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| PHC2 | RNF2 | 0.999 | 0.29 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| PHC2 | PHC3 | 0.999 | 0.238 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RNF2 | CBX4 | 0.999 | 0.316 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| CBX8 | CBX4 | 0.999 | 0.536 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| RNF2 | PHC3 | 0.999 | 0.314 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| PHC2 | CBX7 | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| CBX8 | PHC3 | 0.998 | 0.334 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| RNF2 | CBX8 | 0.998 | 0.228 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| PHC2 | CBX4 | 0.998 | 0.23 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| PHC3 | CBX4 | 0.998 | 0.354 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| RNF2 | CBX7 | 0.998 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| PHC3 | CBX7 | 0.993 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| CBX8 | BCOR | 0.992 | 0.28 | hein_WMM bioplex3_WMM youn_WMM WMM_only |
| PHC2 | BCOR | 0.991 | 0.186 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RNF2 | BCOR | 0.99 | 0.172 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| PHC3 | BCOR | 0.99 | 0.158 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| BCOR | CBX4 | 0.905 | 0.266 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| BCOR | CBX7 | 0.846 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| CBX8 | CBX7 | 0.785 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| CBX4 | CBX7 | 0.737 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes