hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02465.1

Complex Portal: CPX-17300

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
COIL	Coilin (p80-coilin)	5	UniProt NCBI
PATL1	Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b)	5	UniProt NCBI
PRMT5	Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]	5	UniProt NCBI
LSM7	U6 snRNA-associated Sm-like protein LSm7	5	UniProt NCBI
WBP4	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4)	5	UniProt NCBI
LSM1	U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm)	5	UniProt NCBI
TMCO6	Transmembrane and coiled-coil domain-containing protein 6	3	UniProt NCBI
RIOK1	Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1)	5	UniProt NCBI
WDR77	Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)	5	UniProt NCBI
LSM2	U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)	5	UniProt NCBI
LSM6	U6 snRNA-associated Sm-like protein LSm6	5	UniProt NCBI
LSM5	U6 snRNA-associated Sm-like protein LSm5	5	UniProt NCBI
ZNF511	Zinc finger protein 511	5	UniProt NCBI
RBM42	RNA-binding protein 42 (RNA-binding motif protein 42)	5	UniProt NCBI
LSM4	U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:561	1.25716094515e-16	0.4	LSM1 LSM7 LSM6 LSM4 LSM2 LSM5	LSm1-7 complex
REAC:R-HSA-430039	4.37671201829e-16	0.466666666667	LSM1 LSM7 LSM4 LSM6 LSM2 PATL1 LSM5	mRNA decay by 5' to 3' exoribonuclease
CORUM:562	5.50676012339e-13	0.333333333333	LSM2 LSM4 LSM5 LSM7 LSM6	LSm2-8 complex
GO:0000375	4.46522943716e-12	0.733333333333	PRMT5 LSM5 LSM7 WDR77 LSM6 WBP4 COIL RBM42 LSM4 LSM2 LSM1	RNA splicing, via transesterification reactions
REAC:R-HSA-8953854	1.20400804925e-11	0.8	PRMT5 LSM5 LSM7 WDR77 LSM4 WBP4 LSM6 RIOK1 LSM2 PATL1 LSM1 RBM42	Metabolism of RNA
REAC:R-HSA-429914	1.35394875935e-11	0.466666666667	LSM1 LSM7 LSM4 LSM6 LSM2 PATL1 LSM5	Deadenylation-dependent mRNA decay
KEGG:03018	2.05226561806e-11	0.466666666667	LSM1 LSM7 LSM4 LSM6 LSM2 PATL1 LSM5	RNA degradation
GO:0006397	4.90564186363e-11	0.733333333333	PRMT5 LSM5 LSM7 WDR77 LSM6 WBP4 COIL RBM42 LSM4 LSM2 LSM1	mRNA processing
GO:0008380	1.3067883003e-10	0.733333333333	PRMT5 LSM5 LSM7 WDR77 LSM6 WBP4 COIL RBM42 LSM4 LSM2 LSM1	RNA splicing
GO:0016071	1.60679458684e-10	0.8	PRMT5 LSM5 LSM7 WDR77 LSM4 LSM6 WBP4 COIL RBM42 LSM2 PATL1 LSM1	mRNA metabolic process
GO:0000398	4.6714758631e-10	0.666666666667	PRMT5 LSM5 LSM7 WDR77 WBP4 COIL RBM42 LSM4 LSM2 LSM6	mRNA splicing, via spliceosome
GO:0000377	4.6714758631e-10	0.666666666667	PRMT5 LSM5 LSM7 WDR77 WBP4 COIL RBM42 LSM4 LSM2 LSM6	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0120115	5.67196292709e-10	0.333333333333	LSM2 LSM4 LSM5 LSM7 LSM6	Lsm2-8 complex
GO:0005688	1.51166065257e-09	0.333333333333	LSM2 LSM4 LSM5 LSM7 LSM6	U6 snRNP
GO:0006396	7.90033791359e-09	0.8	PRMT5 LSM5 LSM7 WDR77 LSM6 WBP4 COIL RIOK1 LSM4 LSM2 LSM1 RBM42	RNA processing
GO:0046540	2.45258225799e-08	0.4	LSM7 LSM6 RBM42 LSM4 LSM2 LSM5	U4/U6 x U5 tri-snRNP complex
GO:0097526	2.45258225799e-08	0.4	LSM7 LSM6 RBM42 LSM4 LSM2 LSM5	spliceosomal tri-snRNP complex
GO:0120114	5.4209252127e-08	0.466666666667	LSM1 LSM7 LSM6 RBM42 LSM4 LSM2 LSM5	Sm-like protein family complex
REAC:R-HSA-72163	1.47144553849e-07	0.466666666667	LSM7 WBP4 LSM6 RBM42 LSM4 LSM2 LSM5	mRNA Splicing - Major Pathway
GO:1990726	1.79475545894e-07	0.266666666667	LSM2 LSM5 LSM7 LSM1	Lsm1-7-Pat1 complex
REAC:R-HSA-72172	1.87026340607e-07	0.466666666667	LSM7 WBP4 LSM6 RBM42 LSM4 LSM2 LSM5	mRNA Splicing
GO:0071005	2.87341735405e-07	0.4	LSM7 WBP4 LSM6 LSM4 LSM2 LSM5	U2-type precatalytic spliceosome
GO:0071011	3.67741044603e-07	0.4	LSM7 WBP4 LSM6 LSM4 LSM2 LSM5	precatalytic spliceosome
REAC:R-HSA-72203	1.27809076721e-06	0.466666666667	LSM7 WBP4 LSM6 RBM42 LSM4 LSM2 LSM5	Processing of Capped Intron-Containing Pre-mRNA
GO:0097525	1.34570261314e-06	0.4	LSM7 LSM6 RBM42 LSM4 LSM2 LSM5	spliceosomal snRNP complex
GO:0030532	3.04090432346e-06	0.4	LSM7 LSM6 RBM42 LSM4 LSM2 LSM5	small nuclear ribonucleoprotein complex
KEGG:03040	6.75151993135e-06	0.333333333333	LSM2 LSM4 LSM5 LSM7 LSM6	Spliceosome
GO:0005684	1.02929050402e-05	0.4	LSM7 WBP4 LSM6 LSM4 LSM2 LSM5	U2-type spliceosomal complex
GO:0000387	1.52692703458e-05	0.333333333333	PRMT5 LSM4 LSM2 COIL WDR77	spliceosomal snRNP assembly
CORUM:837	0.000143102677271	0.133333333333	PRMT5 WDR77	MEP50-PRMT5-ICLN complex
CORUM:2838	0.000143102677271	0.133333333333	PRMT5 WDR77	MEP50-PRMT5-ICLN complex
GO:0000932	0.000448399105837	0.333333333333	PATL1 LSM4 LSM6 LSM1 LSM2	P-body
CORUM:351	0.000451933310477	0.266666666667	LSM2 LSM4 LSM7 LSM6	Spliceosome
CORUM:6858	0.000476443303259	0.133333333333	PRMT5 WDR77	CHTOP-methylosome complex
GO:0005681	0.000520247571739	0.4	LSM7 WBP4 LSM6 LSM4 LSM2 LSM5	spliceosomal complex
CORUM:810	0.000999344595595	0.133333333333	PRMT5 WDR77	FCP1-associated protein complex
CORUM:811	0.000999344595595	0.133333333333	PRMT5 WDR77	FCP1-associated protein complex
GO:1990904	0.00172995805611	0.533333333333	LSM7 WBP4 LSM6 RIOK1 LSM4 LSM2 LSM5 RBM42	ribonucleoprotein complex
GO:0022613	0.00253039690998	0.466666666667	PRMT5 WDR77 COIL RIOK1 LSM4 LSM2 LSM6	ribonucleoprotein complex biogenesis
GO:0017069	0.00475956790881	0.266666666667	LSM2 LSM4 COIL LSM7	snRNA binding
GO:0003723	0.0060389379995	0.666666666667	LSM5 LSM7 LSM6 LSM4 WBP4 COIL RBM42 LSM2 PATL1 LSM1	RNA binding
GO:0016070	0.0099762017936	0.866666666667	PRMT5 LSM5 LSM7 WDR77 LSM4 LSM6 WBP4 COIL RIOK1 LSM2 PATL1 LSM1 RBM42	RNA metabolic process
GO:0017070	0.0158118674804	0.2	LSM2 LSM7 LSM4	U6 snRNA binding
GO:0003676	0.0259179260221	0.8	PRMT5 LSM5 LSM7 WDR77 LSM4 LSM6 WBP4 COIL RBM42 LSM2 PATL1 LSM1	nucleic acid binding
GO:0022618	0.0428383847677	0.333333333333	PRMT5 LSM4 LSM2 COIL WDR77	protein-RNA complex assembly
GO:0090304	0.0459903481626	0.866666666667	PRMT5 LSM5 LSM7 WDR77 LSM4 LSM6 WBP4 COIL RIOK1 LSM2 PATL1 LSM1 RBM42	nucleic acid metabolic process
CORUM:1748	0.0498224659463	0.0666666666667	PRMT5	PRMT5 complex
CORUM:2764	0.0498224659463	0.0666666666667	PRMT5	PRMT5 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
LSM2	LSM6	1.0	0.982
LSM1	LSM6	1.0	0.334	structurally_consistent (dimer)
LSM6	LSM4	1.0	0.988
LSM7	LSM6	1.0	0.95
LSM1	LSM2	1.0	0.282
LSM5	LSM4	1.0	0.922	mutually_exclusive (O15116)
LSM7	LSM2	1.0	0.966
LSM2	LSM4	1.0	0.964
LSM6	LSM5	1.0	0.868	mutually_exclusive (O15116)
LSM1	LSM5	1.0	0.462	structurally_consistent (dimer)
LSM7	LSM5	1.0	0.896
RIOK1	LSM6	1.0	0.044
PATL1	LSM1	1.0	0.172
LSM7	LSM4	1.0	0.968	structurally_consistent (P83876)
LSM7	LSM1	1.0	0.486	structurally_consistent (dimer)
PRMT5	LSM6	1.0	0.1
LSM1	LSM4	0.999	0.254	structurally_consistent (dimer)
PATL1	LSM6	0.999	0.108
WDR77	LSM6	0.999	0.082
PRMT5	WDR77	0.999	0.914	structurally_consistent (dimer)
TMCO6	ZNF511	0.999	0.208
PATL1	LSM4	0.999	0.098
LSM2	LSM5	0.999	0.864
LSM6	ZNF511	0.999	0.166
PATL1	LSM7	0.999	0.12
PATL1	LSM5	0.998	0.124
PRMT5	LSM4	0.998	0.074	structurally_consistent (dimer)
LSM5	ZNF511	0.998	0.17
COIL	LSM6	0.997	0.06
LSM7	ZNF511	0.997	0.168
WDR77	LSM4	0.996	0.126
TMCO6	LSM5	0.996	0.104
COIL	LSM4	0.996	0.126
LSM7	TMCO6	0.995	0.138
PATL1	LSM2	0.995	0.156
COIL	LSM7	0.995	0.074
RIOK1	LSM4	0.995	0.204	structurally_consistent (O14744)
PRMT5	RIOK1	0.994	0.214	structurally_consistent (dimer)
RIOK1	WDR77	0.994	0.196
RBM42	LSM2	0.993	0.432
WBP4	LSM6	0.993	0.412
ZNF511	LSM4	0.989	0.196
COIL	WBP4	0.989	0.096
RBM42	LSM5	0.985	0.288
RBM42	LSM6	0.983	0.144
COIL	LSM2	0.982	0.202
TMCO6	LSM4	0.982	0.092
WBP4	LSM4	0.981	0.448
RBM42	LSM7	0.98	0.29	mutually_exclusive (O43447)
COIL	LSM5	0.98	0.012
TMCO6	LSM6	0.975	0.072
RIOK1	COIL	0.972	0.152
WDR77	LSM1	0.946	0.094
PRMT5	COIL	0.939	0.344
PRMT5	LSM7	0.935	0.102
WDR77	COIL	0.926	0.154
PRMT5	LSM2	0.919	0.08
PATL1	TMCO6	0.898	0.076
WBP4	LSM2	0.893	0.562
PATL1	ZNF511	0.871	0.166
WDR77	LSM2	0.87	0.254
RBM42	LSM4	0.862	0.328	mutually_exclusive (O43447)
LSM1	ZNF511	0.861	0.084
TMCO6	LSM2	0.851	0.152
LSM2	ZNF511	0.841	0.258
LSM1	TMCO6	0.831	0.046
COIL	ZNF511	0.819	0.078
WDR77	LSM7	0.816	0.2	mutually_exclusive (P62314)
RBM42	WBP4	0.813	0.242
LSM7	WBP4	0.789	0.404
RIOK1	LSM5	0.787	0.034
WBP4	LSM5	0.785	0.328
WDR77	LSM5	0.782	0.076
COIL	TMCO6	0.761	0.078
PRMT5	LSM1	0.648	0.142
RBM42	LSM1	0.64	0.05	mutually_exclusive (P62306)
COIL	LSM1	0.616	0.046
RIOK1	LSM7	0.616	0.048
RIOK1	LSM2	0.559	0.07
RIOK1	PATL1	0.547	0.249138888889
RIOK1	ZNF511	0.539	0.072
RBM42	ZNF511	0.466	0.118
WDR77	ZNF511	0.395	0.094
WDR77	TMCO6	0.391	0.094
PRMT5	LSM5	0.386	0.106
WDR77	PATL1	0.377	0.108
RBM42	COIL	0.361	0.096
PRMT5	ZNF511	0.352	0.11
RIOK1	TMCO6	0.348	0.056
RBM42	TMCO6	0.334	0.068
RBM42	PATL1	0.216	0.056
WBP4	LSM1	0.21	0.136
RIOK1	LSM1	0.197	0.048
COIL	PATL1	0.174	0.156
PRMT5	PATL1	0.169	0.17
RIOK1	WBP4	0.161	0.122
RBM42	WDR77	0.149	0.124
PRMT5	WBP4	0.128	0.118
WBP4	ZNF511	0.102	0.074
WBP4	TMCO6	0.092	0.092
RBM42	RIOK1	0.068	0.038
PRMT5	TMCO6	0.059	0.166
WDR77	WBP4	0.056	0.218
RBM42	PRMT5	0.035	0.24
PATL1	WBP4	0.031	0.216

Related Complexes

Genename	Complexes
COIL	huMAP3_02465.1 huMAP3_06511.1 huMAP3_08980.1
PATL1	huMAP3_02465.1 huMAP3_05636.1 huMAP3_08980.1 huMAP3_13161.1
PRMT5	huMAP3_02247.1 huMAP3_02465.1 huMAP3_03342.1 huMAP3_06511.1 huMAP3_08980.1 huMAP3_11121.1 huMAP3_15239.1
LSM7	huMAP3_02465.1 huMAP3_05636.1 huMAP3_08980.1
WBP4	huMAP3_02465.1 huMAP3_06511.1 huMAP3_08980.1
LSM1	huMAP3_02465.1 huMAP3_05636.1 huMAP3_08980.1
TMCO6	huMAP3_02465.1 huMAP3_05636.1 huMAP3_05850.1 huMAP3_08980.1
RIOK1	huMAP3_02247.1 huMAP3_02465.1 huMAP3_03342.1 huMAP3_06511.1 huMAP3_08980.1 huMAP3_11121.1 huMAP3_15239.1
WDR77	huMAP3_02247.1 huMAP3_02465.1 huMAP3_03342.1 huMAP3_06511.1 huMAP3_08980.1 huMAP3_11121.1 huMAP3_15239.1
LSM2	huMAP3_02465.1 huMAP3_06511.1 huMAP3_08980.1
LSM6	huMAP3_02465.1 huMAP3_05636.1 huMAP3_08980.1
LSM5	huMAP3_02465.1 huMAP3_05636.1 huMAP3_05850.1 huMAP3_08980.1
ZNF511	huMAP3_02465.1 huMAP3_05636.1 huMAP3_05850.1 huMAP3_08980.1
RBM42	huMAP3_00967.1 huMAP3_02465.1 huMAP3_06511.1 huMAP3_08980.1 huMAP3_09381.1 huMAP3_14498.1
LSM4	huMAP3_02465.1 huMAP3_05636.1 huMAP3_08980.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_02465.1

Complex Portal: CPX-17300