List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_02465.1

Confidence: Extremely High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
COIL	Coilin (p80-coilin)	5	UniProt   NCBI
PATL1	Protein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b)	5	UniProt   NCBI
PRMT5	Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]	5	UniProt   NCBI
LSM7	U6 snRNA-associated Sm-like protein LSm7	5	UniProt   NCBI
WBP4	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21) (WW domain-containing-binding protein 4)	5	UniProt   NCBI
LSM1	U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm)	5	UniProt   NCBI
TMCO6	Transmembrane and coiled-coil domain-containing protein 6	3	UniProt   NCBI
RIOK1	Serine/threonine-protein kinase RIO1 (EC 2.7.11.1) (EC 3.6.3.-) (RIO kinase 1)	5	UniProt   NCBI
WDR77	Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)	5	UniProt   NCBI
LSM2	U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)	5	UniProt   NCBI
LSM6	U6 snRNA-associated Sm-like protein LSm6	5	UniProt   NCBI
LSM5	U6 snRNA-associated Sm-like protein LSm5	5	UniProt   NCBI
ZNF511	Zinc finger protein 511	5	UniProt   NCBI
RBM42	RNA-binding protein 42 (RNA-binding motif protein 42)	5	UniProt   NCBI
LSM4	U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:561	1.25716094515e-16	0.4	LSM5 LSM4 LSM7 LSM1 LSM2 LSM6	LSm1-7 complex
REAC:R-HSA-430039	4.37671201829e-16	0.466666666667	LSM5 LSM1 PATL1 LSM7 LSM4 LSM2 LSM6	mRNA decay by 5' to 3' exoribonuclease
CORUM:562	5.50676012339e-13	0.333333333333	LSM2 LSM5 LSM4 LSM7 LSM6	LSm2-8 complex
GO:0000375	4.46522943716e-12	0.733333333333	LSM4 WBP4 LSM1 WDR77 RBM42 LSM5 LSM7 LSM2 PRMT5 COIL LSM6	RNA splicing, via transesterification reactions
REAC:R-HSA-8953854	1.20400804925e-11	0.8	RIOK1 WBP4 LSM4 LSM1 WDR77 PATL1 LSM5 LSM7 LSM2 PRMT5 RBM42 LSM6	Metabolism of RNA
REAC:R-HSA-429914	1.35394875935e-11	0.466666666667	LSM5 LSM1 PATL1 LSM7 LSM4 LSM2 LSM6	Deadenylation-dependent mRNA decay
KEGG:03018	2.05226561806e-11	0.466666666667	LSM5 LSM1 PATL1 LSM7 LSM4 LSM2 LSM6	RNA degradation
GO:0006397	4.90564186363e-11	0.733333333333	LSM4 WBP4 LSM1 WDR77 RBM42 LSM5 LSM7 LSM2 PRMT5 COIL LSM6	mRNA processing
GO:0008380	1.3067883003e-10	0.733333333333	LSM4 WBP4 LSM1 WDR77 RBM42 LSM5 LSM7 LSM2 PRMT5 COIL LSM6	RNA splicing
GO:0016071	1.60679458684e-10	0.8	LSM4 WBP4 LSM1 WDR77 RBM42 PATL1 LSM5 LSM7 LSM2 PRMT5 COIL LSM6	mRNA metabolic process
GO:0000398	4.6714758631e-10	0.666666666667	WBP4 LSM4 WDR77 RBM42 LSM5 LSM7 LSM2 PRMT5 COIL LSM6	mRNA splicing, via spliceosome
GO:0000377	4.6714758631e-10	0.666666666667	WBP4 LSM4 WDR77 RBM42 LSM5 LSM7 LSM2 PRMT5 COIL LSM6	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0120115	5.67196292709e-10	0.333333333333	LSM2 LSM5 LSM4 LSM7 LSM6	Lsm2-8 complex
GO:0005688	1.51166065257e-09	0.333333333333	LSM2 LSM5 LSM4 LSM7 LSM6	U6 snRNP
GO:0006396	7.90033791359e-09	0.8	RIOK1 WBP4 LSM4 LSM1 WDR77 RBM42 LSM5 LSM7 LSM2 PRMT5 COIL LSM6	RNA processing
GO:0046540	2.45258225799e-08	0.4	LSM5 LSM4 LSM7 LSM2 RBM42 LSM6	U4/U6 x U5 tri-snRNP complex
GO:0097526	2.45258225799e-08	0.4	LSM5 LSM4 LSM7 LSM2 RBM42 LSM6	spliceosomal tri-snRNP complex
GO:0120114	5.4209252127e-08	0.466666666667	LSM5 LSM1 LSM7 LSM4 LSM2 RBM42 LSM6	Sm-like protein family complex
REAC:R-HSA-72163	1.47144553849e-07	0.466666666667	LSM5 LSM4 WBP4 LSM7 LSM2 RBM42 LSM6	mRNA Splicing - Major Pathway
GO:1990726	1.79475545894e-07	0.266666666667	LSM1 LSM5 LSM7 LSM2	Lsm1-7-Pat1 complex
REAC:R-HSA-72172	1.87026340607e-07	0.466666666667	LSM5 LSM4 WBP4 LSM7 LSM2 RBM42 LSM6	mRNA Splicing
GO:0071005	2.87341735405e-07	0.4	LSM5 LSM4 WBP4 LSM7 LSM2 LSM6	U2-type precatalytic spliceosome
GO:0071011	3.67741044603e-07	0.4	LSM5 LSM4 WBP4 LSM7 LSM2 LSM6	precatalytic spliceosome
REAC:R-HSA-72203	1.27809076721e-06	0.466666666667	LSM5 LSM4 WBP4 LSM7 LSM2 RBM42 LSM6	Processing of Capped Intron-Containing Pre-mRNA
GO:0097525	1.34570261314e-06	0.4	LSM5 LSM4 LSM7 LSM2 RBM42 LSM6	spliceosomal snRNP complex
GO:0030532	3.04090432346e-06	0.4	LSM5 LSM4 LSM7 LSM2 RBM42 LSM6	small nuclear ribonucleoprotein complex
KEGG:03040	6.75151993135e-06	0.333333333333	LSM2 LSM5 LSM4 LSM7 LSM6	Spliceosome
GO:0005684	1.02929050402e-05	0.4	LSM5 LSM4 WBP4 LSM7 LSM2 LSM6	U2-type spliceosomal complex
GO:0000387	1.52692703458e-05	0.333333333333	PRMT5 LSM4 LSM2 COIL WDR77	spliceosomal snRNP assembly
CORUM:837	0.000143102677271	0.133333333333	PRMT5 WDR77	MEP50-PRMT5-ICLN complex
CORUM:2838	0.000143102677271	0.133333333333	PRMT5 WDR77	MEP50-PRMT5-ICLN complex
GO:0000932	0.000448399105837	0.333333333333	PATL1 LSM4 LSM2 LSM6 LSM1	P-body
CORUM:351	0.000451933310477	0.266666666667	LSM2 LSM4 LSM7 LSM6	Spliceosome
CORUM:6858	0.000476443303259	0.133333333333	PRMT5 WDR77	CHTOP-methylosome complex
GO:0005681	0.000520247571739	0.4	LSM5 LSM4 WBP4 LSM7 LSM2 LSM6	spliceosomal complex
CORUM:810	0.000999344595595	0.133333333333	PRMT5 WDR77	FCP1-associated protein complex
CORUM:811	0.000999344595595	0.133333333333	PRMT5 WDR77	FCP1-associated protein complex
GO:1990904	0.00172995805611	0.533333333333	RIOK1 LSM5 LSM4 WBP4 LSM7 LSM2 RBM42 LSM6	ribonucleoprotein complex
GO:0022613	0.00253039690998	0.466666666667	RIOK1 LSM6 LSM4 WDR77 PRMT5 LSM2 COIL	ribonucleoprotein complex biogenesis
GO:0017069	0.00475956790881	0.266666666667	LSM2 LSM4 COIL LSM7	snRNA binding
GO:0003723	0.0060389379995	0.666666666667	WBP4 LSM1 RBM42 PATL1 LSM5 LSM7 LSM4 LSM2 COIL LSM6	RNA binding
GO:0016070	0.0099762017936	0.866666666667	RIOK1 WBP4 LSM4 LSM1 WDR77 RBM42 PATL1 LSM5 LSM7 LSM2 PRMT5 COIL LSM6	RNA metabolic process
GO:0017070	0.0158118674804	0.2	LSM2 LSM7 LSM4	U6 snRNA binding
GO:0003676	0.0259179260221	0.8	LSM4 WBP4 LSM1 WDR77 RBM42 PATL1 LSM5 LSM7 LSM2 PRMT5 COIL LSM6	nucleic acid binding
GO:0022618	0.0428383847677	0.333333333333	PRMT5 LSM4 LSM2 COIL WDR77	protein-RNA complex assembly
GO:0090304	0.0459903481626	0.866666666667	RIOK1 WBP4 LSM4 LSM1 WDR77 RBM42 PATL1 LSM5 LSM7 LSM2 PRMT5 COIL LSM6	nucleic acid metabolic process
CORUM:1748	0.0498224659463	0.0666666666667	PRMT5	PRMT5 complex
CORUM:2764	0.0498224659463	0.0666666666667	PRMT5	PRMT5 complex



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
LSM2	LSM6	1.0	0.982
LSM1	LSM6	1.0	0.334
LSM6	LSM4	1.0	0.988
LSM7	LSM6	1.0	0.95
LSM1	LSM2	1.0	0.282
LSM5	LSM4	1.0	0.922
LSM7	LSM2	1.0	0.966
LSM2	LSM4	1.0	0.964
LSM6	LSM5	1.0	0.868
LSM1	LSM5	1.0	0.462
LSM7	LSM5	1.0	0.896
RIOK1	LSM6	1.0	0.044
PATL1	LSM1	1.0	0.172
LSM7	LSM4	1.0	0.968
LSM7	LSM1	1.0	0.486
PRMT5	LSM6	1.0	0.1
LSM1	LSM4	0.999	0.254
PATL1	LSM6	0.999	0.108
WDR77	LSM6	0.999	0.082
PRMT5	WDR77	0.999	0.914
TMCO6	ZNF511	0.999	0.208
PATL1	LSM4	0.999	0.098
LSM2	LSM5	0.999	0.864
LSM6	ZNF511	0.999	0.166
PATL1	LSM7	0.999	0.12
PATL1	LSM5	0.998	0.124
PRMT5	LSM4	0.998	0.074
LSM5	ZNF511	0.998	0.17
COIL	LSM6	0.997	0.06
LSM7	ZNF511	0.997	0.168
WDR77	LSM4	0.996	0.126
TMCO6	LSM5	0.996	0.104
COIL	LSM4	0.996	0.126
LSM7	TMCO6	0.995	0.138
PATL1	LSM2	0.995	0.156
COIL	LSM7	0.995	0.074
RIOK1	LSM4	0.995	0.204
PRMT5	RIOK1	0.994	0.214
RIOK1	WDR77	0.994	0.196
RBM42	LSM2	0.993	0.432
WBP4	LSM6	0.993	0.412
ZNF511	LSM4	0.989	0.196
COIL	WBP4	0.989	0.096
RBM42	LSM5	0.985	0.288
RBM42	LSM6	0.983	0.144
COIL	LSM2	0.982	0.202
TMCO6	LSM4	0.982	0.092
WBP4	LSM4	0.981	0.448
RBM42	LSM7	0.98	0.29
COIL	LSM5	0.98	0.012
TMCO6	LSM6	0.975	0.072
RIOK1	COIL	0.972	0.152
WDR77	LSM1	0.946	0.094
PRMT5	COIL	0.939	0.344
PRMT5	LSM7	0.935	0.102
WDR77	COIL	0.926	0.154
PRMT5	LSM2	0.919	0.08
PATL1	TMCO6	0.898	0.076
WBP4	LSM2	0.893	0.562
PATL1	ZNF511	0.871	0.166
WDR77	LSM2	0.87	0.254
RBM42	LSM4	0.862	0.328
LSM1	ZNF511	0.861	0.084
TMCO6	LSM2	0.851	0.152
LSM2	ZNF511	0.841	0.258
LSM1	TMCO6	0.831	0.046
COIL	ZNF511	0.819	0.078
WDR77	LSM7	0.816	0.2
RBM42	WBP4	0.813	0.242
LSM7	WBP4	0.789	0.404
RIOK1	LSM5	0.787	0.034
WBP4	LSM5	0.785	0.328
WDR77	LSM5	0.782	0.076
COIL	TMCO6	0.761	0.078
PRMT5	LSM1	0.648	0.142
RBM42	LSM1	0.64	0.05
COIL	LSM1	0.616	0.046
RIOK1	LSM7	0.616	0.048
RIOK1	LSM2	0.559	0.07
RIOK1	PATL1	0.547	0.249138888889
RIOK1	ZNF511	0.539	0.072
RBM42	ZNF511	0.466	0.118
WDR77	ZNF511	0.395	0.094
WDR77	TMCO6	0.391	0.094
PRMT5	LSM5	0.386	0.106
WDR77	PATL1	0.377	0.108
RBM42	COIL	0.361	0.096
PRMT5	ZNF511	0.352	0.11
RIOK1	TMCO6	0.348	0.056
RBM42	TMCO6	0.334	0.068
RBM42	PATL1	0.216	0.056
WBP4	LSM1	0.21	0.136
RIOK1	LSM1	0.197	0.048
COIL	PATL1	0.174	0.156
PRMT5	PATL1	0.169	0.17
RIOK1	WBP4	0.161	0.122
RBM42	WDR77	0.149	0.124
PRMT5	WBP4	0.128	0.118
WBP4	ZNF511	0.102	0.074
WBP4	TMCO6	0.092	0.092
RBM42	RIOK1	0.068	0.038
PRMT5	TMCO6	0.059	0.166
WDR77	WBP4	0.056	0.218
RBM42	PRMT5	0.035	0.24
PATL1	WBP4	0.031	0.216





Related Complexes

Genename	Complexes
COIL	huMAP3_02465.1 huMAP3_06511.1 huMAP3_08980.1
PATL1	huMAP3_02465.1 huMAP3_05636.1 huMAP3_08980.1 huMAP3_13161.1
PRMT5	huMAP3_02247.1 huMAP3_02465.1 huMAP3_03342.1 huMAP3_06511.1 huMAP3_08980.1 huMAP3_11121.1 huMAP3_15239.1
LSM7	huMAP3_02465.1 huMAP3_05636.1 huMAP3_08980.1
WBP4	huMAP3_02465.1 huMAP3_06511.1 huMAP3_08980.1
LSM1	huMAP3_02465.1 huMAP3_05636.1 huMAP3_08980.1
TMCO6	huMAP3_02465.1 huMAP3_05636.1 huMAP3_05850.1 huMAP3_08980.1
RIOK1	huMAP3_02247.1 huMAP3_02465.1 huMAP3_03342.1 huMAP3_06511.1 huMAP3_08980.1 huMAP3_11121.1 huMAP3_15239.1
WDR77	huMAP3_02247.1 huMAP3_02465.1 huMAP3_03342.1 huMAP3_06511.1 huMAP3_08980.1 huMAP3_11121.1 huMAP3_15239.1
LSM2	huMAP3_02465.1 huMAP3_06511.1 huMAP3_08980.1
LSM6	huMAP3_02465.1 huMAP3_05636.1 huMAP3_08980.1
LSM5	huMAP3_02465.1 huMAP3_05636.1 huMAP3_05850.1 huMAP3_08980.1
ZNF511	huMAP3_02465.1 huMAP3_05636.1 huMAP3_05850.1 huMAP3_08980.1
RBM42	huMAP3_00967.1 huMAP3_02465.1 huMAP3_06511.1 huMAP3_08980.1 huMAP3_09381.1 huMAP3_14498.1
LSM4	huMAP3_02465.1 huMAP3_05636.1 huMAP3_08980.1