hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02474.1

Complex Portal: CPX-10915

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
WASF3	Actin-binding protein WASF3 (Protein WAVE-3) (Verprolin homology domain-containing protein 3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3)	5	UniProt NCBI
NCKAP1L	Nck-associated protein 1-like (Hematopoietic protein 1) (Membrane-associated protein HEM-1)	5	UniProt NCBI
RAPH1	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 18 protein) (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 9 protein) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1)	5	UniProt NCBI
ABI1	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)	5	UniProt NCBI
WASF2	Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2)	5	UniProt NCBI
NHSL1	NHS-like protein 1	3	UniProt NCBI
NCKAP1	Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1)	5	UniProt NCBI
CYFIP1	Cytoplasmic FMR1-interacting protein 1 (Specifically Rac1-associated protein 1) (Sra-1) (p140sra-1)	5	UniProt NCBI
CYFIP2	Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)	5	UniProt NCBI
ABI2	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1)	5	UniProt NCBI
WASF1	Actin-binding protein WASF1 (Protein WAVE-1) (Verprolin homology domain-containing protein 1) (Wiskott-Aldrich syndrome protein family member 1) (WASP family protein member 1)	5	UniProt NCBI
NHSL3	NHS-like protein 3	5	UniProt NCBI
Q56UQ5	TPT1-like protein	1	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0031209	7.23166698062e-24	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	SCAR complex
REAC:R-HSA-5663213	3.73220677404e-20	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	RHO GTPases Activate WASPs and WAVEs
REAC:R-HSA-9664422	3.14226677892e-18	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	FCGR3A-mediated phagocytosis
REAC:R-HSA-9664417	3.14226677892e-18	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Leishmania phagocytosis
REAC:R-HSA-9664407	3.14226677892e-18	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Parasite infection
REAC:R-HSA-2029482	5.36880713774e-18	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Regulation of actin dynamics for phagocytic cup formation
REAC:R-HSA-2029480	1.28708654206e-16	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Fcgamma receptor (FCGR) dependent phagocytosis
REAC:R-HSA-4420097	3.61400090602e-16	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	VEGFA-VEGFR2 Pathway
REAC:R-HSA-194138	8.26667527242e-16	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Signaling by VEGF
REAC:R-HSA-9824443	2.33688385157e-14	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Parasitic Infection Pathways
REAC:R-HSA-9658195	2.33688385157e-14	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Leishmania infection
REAC:R-HSA-9013149	9.32342728329e-14	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	RAC1 GTPase cycle
GO:2000601	9.56047657747e-14	0.5	ABI2 NCKAP1 WASF3 WASF1 WASF2 CYFIP1	positive regulation of Arp2/3 complex-mediated actin nucleation
GO:0051127	1.57581298328e-12	0.5	ABI2 NCKAP1 WASF3 WASF1 WASF2 CYFIP1	positive regulation of actin nucleation
KEGG:05130	5.51057477237e-12	0.666666666667	WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Pathogenic Escherichia coli infection
REAC:R-HSA-195258	2.88074016963e-11	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	RHO GTPase Effectors
REAC:R-HSA-9013423	4.00197044367e-11	0.583333333333	ABI2 ABI1 NCKAP1 CYFIP1 NCKAP1L WASF1 WASF2	RAC3 GTPase cycle
CORUM:186	7.91912844737e-11	0.333333333333	NCKAP1 CYFIP1 ABI1 WASF2	Wave-2 complex
REAC:R-HSA-9012999	3.82539315063e-10	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	RHO GTPase cycle
GO:0034315	7.81141062112e-10	0.5	ABI2 NCKAP1 WASF3 WASF1 WASF2 CYFIP1	regulation of Arp2/3 complex-mediated actin nucleation
REAC:R-HSA-9006934	8.76952235265e-10	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Signaling by Receptor Tyrosine Kinases
KEGG:04810	2.62972620242e-09	0.583333333333	ABI2 CYFIP2 NCKAP1 CYFIP1 NCKAP1L WASF1 WASF2	Regulation of actin cytoskeleton
GO:0051125	3.06809789974e-09	0.5	ABI2 NCKAP1 WASF3 WASF1 WASF2 CYFIP1	regulation of actin nucleation
REAC:R-HSA-9013404	6.82131004807e-09	0.5	ABI2 ABI1 NCKAP1 CYFIP1 NCKAP1L WASF2	RAC2 GTPase cycle
GO:0034314	1.2959007851e-08	0.5	ABI2 NCKAP1 WASF3 WASF1 WASF2 CYFIP1	Arp2/3 complex-mediated actin nucleation
REAC:R-HSA-194315	2.58687238634e-08	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Signaling by Rho GTPases
GO:0045010	2.74506137172e-08	0.5	ABI2 NCKAP1 WASF3 WASF1 WASF2 CYFIP1	actin nucleation
REAC:R-HSA-9716542	3.14817553673e-08	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
GO:0030027	1.08003255058e-07	0.583333333333	ABI2 NCKAP1 ABI1 WASF3 CYFIP1 WASF1 WASF2	lamellipodium
GO:1902905	1.20954209527e-07	0.583333333333	ABI2 NCKAP1 WASF3 WASF2 NCKAP1L WASF1 CYFIP1	positive regulation of supramolecular fiber organization
GO:0051495	1.50882682872e-07	0.583333333333	ABI2 NCKAP1 WASF3 WASF2 NCKAP1L WASF1 CYFIP1	positive regulation of cytoskeleton organization
REAC:R-HSA-5663205	4.30968066088e-07	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Infectious disease
KEGG:05132	5.39210505212e-07	0.5	NCKAP1 CYFIP2 ABI1 WASF3 CYFIP1 NCKAP1L	Salmonella infection
REAC:R-HSA-168249	5.49537309265e-07	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Innate Immune System
GO:0110053	1.43791073991e-06	0.583333333333	ABI2 NCKAP1 WASF3 WASF2 NCKAP1L WASF1 CYFIP1	regulation of actin filament organization
GO:0007015	1.68104462154e-06	0.666666666667	ABI2 WASF3 ABI1 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	actin filament organization
WP:WP51	4.19639394298e-06	0.416666666667	NCKAP1 WASF1 ABI2 WASF2 CYFIP2	Regulation of actin cytoskeleton
GO:0032956	8.59023247551e-06	0.583333333333	ABI2 NCKAP1 WASF3 WASF2 NCKAP1L WASF1 CYFIP1	regulation of actin cytoskeleton organization
GO:0008154	1.19884412659e-05	0.5	ABI2 NCKAP1 ABI1 WASF3 WASF1 NCKAP1L	actin polymerization or depolymerization
GO:0031252	1.45103830251e-05	0.583333333333	ABI2 NCKAP1 ABI1 WASF3 CYFIP1 WASF1 WASF2	cell leading edge
GO:0032970	1.85908662423e-05	0.583333333333	ABI2 NCKAP1 WASF3 WASF2 NCKAP1L WASF1 CYFIP1	regulation of actin filament-based process
GO:1902903	2.42369700664e-05	0.583333333333	ABI2 NCKAP1 WASF3 WASF2 NCKAP1L WASF1 CYFIP1	regulation of supramolecular fiber organization
CORUM:6991	3.75927585468e-05	0.166666666667	WASF2 CYFIP1	ABI3-WAVE2-CYFIP1 complex
CORUM:2294	3.75927585468e-05	0.166666666667	ABI1 WASF2	ABI1-WASF2 complex
CORUM:7561	3.75927585468e-05	0.166666666667	WASF3 NCKAP1	NCKAP1-WASF3 complex
REAC:R-HSA-1643685	5.07381061057e-05	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Disease
GO:0030036	6.27489836348e-05	0.666666666667	ABI2 WASF3 ABI1 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	actin cytoskeleton organization
GO:0097581	7.24897834276e-05	0.416666666667	NCKAP1 WASF1 ABI2 WASF2 CYFIP1	lamellipodium organization
CORUM:7562	0.000112726824524	0.166666666667	WASF3 NCKAP1	NCKAP1-WASF3-RAC1 complex
GO:0010592	0.000114377756046	0.333333333333	NCKAP1 ABI2 WASF2 CYFIP1	positive regulation of lamellipodium assembly
GO:0030029	0.000148299709923	0.666666666667	ABI2 WASF3 ABI1 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	actin filament-based process
REAC:R-HSA-168256	0.000153878122856	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Immune System
GO:0097435	0.000176048037019	0.666666666667	ABI2 WASF3 ABI1 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	supramolecular fiber organization
GO:0051493	0.000259497613181	0.583333333333	ABI2 NCKAP1 WASF3 WASF2 NCKAP1L WASF1 CYFIP1	regulation of cytoskeleton organization
GO:0010638	0.000333967502236	0.583333333333	ABI2 NCKAP1 WASF3 WASF2 NCKAP1L WASF1 CYFIP1	positive regulation of organelle organization
GO:0010591	0.000352898456196	0.333333333333	NCKAP1 ABI2 WASF2 CYFIP1	regulation of lamellipodium assembly
GO:1902745	0.000405002050765	0.333333333333	NCKAP1 ABI2 WASF2 CYFIP1	positive regulation of lamellipodium organization
GO:0016601	0.000405002050765	0.333333333333	NCKAP1 WASF1 CYFIP1 ABI2	Rac protein signal transduction
REAC:R-HSA-162582	0.000741552575954	0.75	ABI2 WASF3 ABI1 CYFIP2 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	Signal Transduction
CORUM:2300	0.00104971930231	0.166666666667	NCKAP1 CYFIP1	Profilin 2 complex
GO:1902743	0.00143377293746	0.333333333333	NCKAP1 ABI2 WASF2 CYFIP1	regulation of lamellipodium organization
KEGG:05231	0.00194634003274	0.25	WASF3 WASF2 WASF1	Choline metabolism in cancer
KEGG:04520	0.00216488710278	0.25	WASF3 WASF2 WASF1	Adherens junction
KEGG:04666	0.00248055863275	0.25	WASF3 WASF2 WASF1	Fc gamma R-mediated phagocytosis
GO:0000902	0.00264660884943	0.583333333333	ABI2 NCKAP1 CYFIP2 WASF3 CYFIP1 NCKAP1L WASF1	cell morphogenesis
GO:0030032	0.00345268026017	0.333333333333	NCKAP1 ABI2 WASF2 CYFIP1	lamellipodium assembly
GO:0071933	0.00765826511887	0.25	WASF3 WASF2 WASF1	Arp2/3 complex binding
GO:0120039	0.01183743901	0.5	ABI2 CYFIP2 NCKAP1 WASF1 NCKAP1L CYFIP1	plasma membrane bounded cell projection morphogenesis
GO:0048858	0.0125942558623	0.5	ABI2 CYFIP2 NCKAP1 WASF1 NCKAP1L CYFIP1	cell projection morphogenesis
GO:0120034	0.0170704961012	0.333333333333	NCKAP1 ABI2 WASF2 CYFIP1	positive regulation of plasma membrane bounded cell projection assembly
GO:0007010	0.0191816160898	0.666666666667	ABI2 WASF3 ABI1 NCKAP1 WASF2 NCKAP1L WASF1 CYFIP1	cytoskeleton organization
GO:0030031	0.0193662002445	0.5	ABI2 CYFIP2 NCKAP1 CYFIP1 NCKAP1L WASF2	cell projection assembly
GO:0034237	0.0278917334495	0.25	WASF3 WASF2 WASF1	protein kinase A regulatory subunit binding
GO:0032989	0.0300680178791	0.5	ABI2 CYFIP2 NCKAP1 WASF1 NCKAP1L CYFIP1	cellular anatomical entity morphogenesis
HPA:0100132	0.0338367549432	0.833333333333	ABI2 NHSL3 NCKAP1 ABI1 WASF3 WASF2 NCKAP1L WASF1 CYFIP1 RAPH1	cerebral cortex; neuronal cells[>=Medium]
GO:0051130	0.0341208486472	0.583333333333	ABI2 NCKAP1 WASF3 WASF2 NCKAP1L WASF1 CYFIP1	positive regulation of cellular component organization
GO:0120025	0.0399938899493	0.666666666667	ABI2 NCKAP1 CYFIP2 ABI1 WASF3 CYFIP1 WASF1 WASF2	plasma membrane bounded cell projection
GO:0042995	0.0431477082637	0.666666666667	ABI2 NCKAP1 CYFIP2 ABI1 WASF3 CYFIP1 WASF1 WASF2	cell projection
GO:0030041	0.0451474140639	0.333333333333	WASF3 WASF1 NCKAP1 NCKAP1L	actin filament polymerization

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
WASF3	CYFIP2	1.0	0.208	structurally_consistent (dimer)
WASF2	NCKAP1	1.0	0.326
ABI2	WASF1	1.0	0.226
NCKAP1	WASF1	1.0	0.16
ABI1	NHSL3	1.0
ABI1	NCKAP1	1.0
NCKAP1	CYFIP2	1.0	0.118
WASF2	NHSL3	1.0	0.112
ABI1	ABI2	1.0
CYFIP1	NHSL3	1.0	0.126
WASF2	ABI2	1.0	0.328
WASF3	ABI2	0.999	0.138	structurally_consistent (dimer)
ABI1	WASF2	0.999		mutually_exclusive (Q8WUW1)
WASF2	CYFIP2	0.999	0.092	structurally_consistent (dimer)
WASF3	NCKAP1	0.999	0.132
CYFIP1	ABI2	0.999	0.398	mutually_exclusive (Q9UPY6)
NCKAP1	NHSL3	0.999	0.122
NCKAP1	ABI2	0.999	0.404
ABI1	WASF1	0.999		mutually_exclusive (Q8WUW1)
CYFIP2	WASF1	0.999	0.228	structurally_consistent (dimer)
WASF3	CYFIP1	0.999	0.118	structurally_consistent (dimer)
ABI1	CYFIP1	0.999
WASF3	ABI1	0.999
NCKAP1	CYFIP1	0.999	0.884	structurally_consistent (dimer)
NHSL1	NCKAP1	0.999
NHSL1	CYFIP1	0.999
NCKAP1L	ABI2	0.999	0.076
NHSL1	ABI2	0.999
ABI1	NHSL1	0.999
CYFIP2	NHSL3	0.999	0.09
NHSL1	WASF1	0.998
CYFIP2	ABI2	0.998	0.074
WASF2	WASF1	0.998	0.092
ABI2	NHSL3	0.998	0.044
WASF1	NHSL3	0.998	0.074
WASF2	CYFIP1	0.997	0.69	structurally_consistent (dimer)
ABI1	CYFIP2	0.997
WASF2	NHSL1	0.996
WASF3	NHSL3	0.996	0.13
CYFIP1	WASF1	0.995	0.09	structurally_consistent (dimer)
Q56UQ5	WASF2	0.993
WASF3	WASF1	0.992	0.166	mutually_exclusive (Q96F07)
WASF3	WASF2	0.992	0.076	mutually_exclusive (Q96F07)
NHSL1	CYFIP2	0.989
RAPH1	ABI2	0.989	0.108
Q56UQ5	CYFIP2	0.986
Q56UQ5	ABI1	0.985
Q56UQ5	CYFIP1	0.98
RAPH1	ABI1	0.979
NHSL1	NHSL3	0.977
Q56UQ5	NCKAP1	0.97
WASF3	NHSL1	0.967
Q56UQ5	ABI2	0.962
RAPH1	NCKAP1	0.942	0.116
RAPH1	WASF1	0.938	0.122
NCKAP1L	CYFIP2	0.93	0.388
CYFIP1	CYFIP2	0.924	0.202
Q56UQ5	WASF1	0.915
RAPH1	NHSL3	0.913	0.09
NCKAP1L	ABI1	0.911
RAPH1	WASF2	0.905	0.132
RAPH1	CYFIP1	0.889	0.138
WASF3	NCKAP1L	0.812
NCKAP1L	WASF1	0.807	0.102
NCKAP1L	NHSL1	0.779
NCKAP1L	NHSL3	0.765	0.066
WASF3	Q56UQ5	0.715
NCKAP1L	WASF2	0.713	0.22
NCKAP1L	CYFIP1	0.582	0.378	structurally_consistent (dimer)
NCKAP1L	NCKAP1	0.514	0.108
Q56UQ5	NHSL3	0.499
Q56UQ5	NHSL1	0.499
RAPH1	NCKAP1L	0.362	0.044
RAPH1	WASF3	0.327	0.17
RAPH1	NHSL1	0.291
NCKAP1L	Q56UQ5	0.274
RAPH1	CYFIP2	0.239	0.08
RAPH1	Q56UQ5	0.224

Related Complexes

Genename	Complexes
WASF3	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
NCKAP1L	huMAP3_02474.1 huMAP3_03690.1 huMAP3_09598.1 huMAP3_13345.1 huMAP3_13550.1
RAPH1	huMAP3_02072.1 huMAP3_02474.1 huMAP3_09598.1 huMAP3_10837.1 huMAP3_13345.1
ABI1	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
WASF2	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
NHSL1	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
NCKAP1	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
CYFIP1	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
CYFIP2	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
ABI2	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
WASF1	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
NHSL3	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1
Q56UQ5	huMAP3_02474.1 huMAP3_09598.1 huMAP3_13345.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_02474.1

Complex Portal: CPX-10915