hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02481.1
Complex Portal: CPX-11237
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PAMR1 | Inactive serine protease PAMR1 (Peptidase domain-containing protein associated with muscle regeneration 1) (Regeneration-associated muscle protease homolog) | 4 | UniProt NCBI |
| SNX5 | Sorting nexin-5 | 5 | UniProt NCBI |
| SNX6 | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] | 5 | UniProt NCBI |
| SNX1 | Sorting nexin-1 | 5 | UniProt NCBI |
| SNX2 | Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) | 5 | UniProt NCBI |
| SNX32 | Sorting nexin-32 (Sorting nexin-6B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030905 | 3.94689465137e-10 | 0.666666666667 | SNX5 SNX1 SNX2 SNX6 | retromer, tubulation complex |
| KEGG:04144 | 2.8969997442e-07 | 0.833333333333 | SNX5 SNX1 SNX2 SNX32 SNX6 | Endocytosis |
| GO:0030904 | 1.52730449682e-06 | 0.666666666667 | SNX5 SNX1 SNX2 SNX6 | retromer complex |
| GO:0042147 | 1.66038655046e-06 | 0.833333333333 | SNX5 SNX1 SNX2 SNX32 SNX6 | retrograde transport, endosome to Golgi |
| GO:0016482 | 9.80306376797e-06 | 0.833333333333 | SNX5 SNX1 SNX2 SNX32 SNX6 | cytosolic transport |
| CORUM:1058 | 1.70876175213e-05 | 0.333333333333 | SNX6 SNX1 | SNX complex (SNX1, SNX6) |
| CORUM:1096 | 5.12534978153e-05 | 0.333333333333 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, PDGFRA) |
| CORUM:1070 | 5.12534978153e-05 | 0.333333333333 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4) |
| CORUM:1093 | 0.000102488289015 | 0.333333333333 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, INSR) |
| CORUM:1091 | 0.000102488289015 | 0.333333333333 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, LEPR) |
| CORUM:1095 | 0.000102488289015 | 0.333333333333 | SNX1 SNX2 | SNX complex (SNX1, SNX1a, SNX2, SNX4, EGFR) |
| CORUM:657 | 0.000170782642132 | 0.333333333333 | SNX1 SNX2 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| CORUM:1059 | 0.000170782642132 | 0.333333333333 | SNX1 SNX2 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| CORUM:1060 | 0.000170782642132 | 0.333333333333 | SNX1 SNX2 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) |
| GO:0016197 | 0.000368555564933 | 0.833333333333 | SNX5 SNX1 SNX2 SNX32 SNX6 | endosomal transport |
| REAC:R-HSA-432722 | 0.03659902859 | 0.333333333333 | SNX5 SNX2 | Golgi Associated Vesicle Biogenesis |
| GO:1990460 | 0.042122686785 | 0.333333333333 | SNX1 SNX2 | leptin receptor binding |
| CORUM:1072 | 0.0499436884912 | 0.166666666667 | SNX2 | SNX complex (SNX2), oligomeric |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SNX5 | SNX1 | 1.0 | 0.326 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| SNX6 | SNX1 | 1.0 | 0.562 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| SNX1 | SNX2 | 1.0 | 0.378 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| SNX1 | SNX32 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SNX6 | SNX2 | 0.997 | 0.384 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction |
| SNX6 | SNX32 | 0.996 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PAMR1 | SNX1 | 0.992 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SNX2 | SNX32 | 0.987 |
mutually_exclusive (Q9UNH7)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SNX5 | SNX2 | 0.984 | 0.33 |
mutually_exclusive (Q9UNH7)
structurally_consistent (dimer) |
bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction |
| PAMR1 | SNX32 | 0.902 | bioplex3_WMM WMM_only | ||
| SNX5 | SNX6 | 0.865 | 0.146 |
mutually_exclusive (O60749)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PAMR1 | SNX5 | 0.86 | bioplex3_WMM WMM_only | ||
| SNX5 | SNX32 | 0.73 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PAMR1 | SNX6 | 0.715 | bioplex3_WMM WMM_only | ||
| PAMR1 | SNX2 | 0.356 | bioplex3_WMM WMM_only |
Related Complexes