hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02506.1
Complex Portal: CPX-20066
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF5A2 | Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) | 5 | UniProt NCBI |
| TFAP2B | Transcription factor AP-2-beta (AP2-beta) (Activating enhancer-binding protein 2-beta) | 5 | UniProt NCBI |
| MCFD2 | Multiple coagulation factor deficiency protein 2 (Neural stem cell-derived neuronal survival protein) | 5 | UniProt NCBI |
| DOHH | Deoxyhypusine hydroxylase (hDOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) (HEAT-like repeat-containing protein 1) | 5 | UniProt NCBI |
| CPB1 | Carboxypeptidase B (EC 3.4.17.2) (Pancreas-specific protein) (PASP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204626 | 6.15041976665e-05 | 0.5 | DOHH EIF5A2 | Hypusine synthesis from eIF5A-lysine |
| REAC:R-HSA-163841 | 0.0068064250699 | 0.5 | DOHH EIF5A2 | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation |
| REAC:R-HSA-597592 | 0.0091733555377 | 1.0 | MCFD2 EIF5A2 DOHH TFAP2B | Post-translational protein modification |
| REAC:R-HSA-392499 | 0.0339333915692 | 1.0 | MCFD2 EIF5A2 DOHH TFAP2B | Metabolism of proteins |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DOHH | EIF5A2 | 0.999 | 0.168 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| CPB1 | EIF5A2 | 0.998 | 0.12 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EIF5A2 | TFAP2B | 0.989 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MCFD2 | EIF5A2 | 0.96 | 0.118 | bioplex3_WMM bioplex3_HCT116 fraction | |
| MCFD2 | CPB1 | 0.89 | bioplex3_WMM WMM_only | ||
| DOHH | CPB1 | 0.888 | bioplex3_WMM WMM_only | ||
| MCFD2 | DOHH | 0.617 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only | |
| CPB1 | TFAP2B | 0.214 | bioplex3_WMM WMM_only | ||
| DOHH | TFAP2B | 0.175 | bioplex3_WMM WMM_only | ||
| MCFD2 | TFAP2B | 0.123 | bioplex3_WMM WMM_only |
Related Complexes