hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02517.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BIRC3 | Baculoviral IAP repeat-containing protein 3 (EC 2.3.2.27) (Apoptosis inhibitor 2) (API2) (Cellular inhibitor of apoptosis 2) (C-IAP2) (IAP homolog C) (Inhibitor of apoptosis protein 1) (hIAP-1) (hIAP1) (RING finger protein 49) (RING-type E3 ubiquitin transferase BIRC3) (TNFR2-TRAF-signaling complex protein 1) | 5 | UniProt NCBI |
| HTRA2 | Serine protease HTRA2, mitochondrial (EC 3.4.21.108) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine protease 25) (Serine proteinase OMI) | 5 | UniProt NCBI |
| TANK | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | 5 | UniProt NCBI |
| TRAF2 | TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) | 5 | UniProt NCBI |
| TRAF1 | TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) | 5 | UniProt NCBI |
| IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5357905 | 1.96121538405e-07 | 0.666666666667 | TRAF2 IKBKE BIRC3 TRAF1 | Regulation of TNFR1 signaling |
| REAC:R-HSA-75893 | 4.22631019131e-07 | 0.666666666667 | TRAF2 IKBKE BIRC3 TRAF1 | TNF signaling |
| WP:WP231 | 1.08306619825e-06 | 0.666666666667 | TANK BIRC3 TRAF1 TRAF2 | TNF alpha signaling pathway |
| KEGG:04210 | 3.31382440797e-06 | 0.666666666667 | HTRA2 BIRC3 TRAF1 TRAF2 | Apoptosis |
| REAC:R-HSA-168164 | 3.8413583752e-06 | 0.666666666667 | TANK IKBKE BIRC3 TRAF2 | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166166 | 4.19553514217e-06 | 0.666666666667 | TANK IKBKE BIRC3 TRAF2 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 4.19553514217e-06 | 0.666666666667 | TANK IKBKE BIRC3 TRAF2 | TRIF(TICAM1)-mediated TLR4 signaling |
| KEGG:04621 | 7.30647383506e-06 | 0.666666666667 | TANK IKBKE BIRC3 TRAF2 | NOD-like receptor signaling pathway |
| REAC:R-HSA-166016 | 1.3002582966e-05 | 0.666666666667 | TANK IKBKE BIRC3 TRAF2 | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-5357786 | 1.42587173715e-05 | 0.5 | TRAF2 BIRC3 IKBKE | TNFR1-induced proapoptotic signaling |
| REAC:R-HSA-73887 | 1.47949188148e-05 | 0.666666666667 | TRAF2 IKBKE BIRC3 TRAF1 | Death Receptor Signaling |
| WP:WP2036 | 1.95929934718e-05 | 0.5 | TRAF2 BIRC3 TRAF1 | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| REAC:R-HSA-168898 | 2.32027043518e-05 | 0.666666666667 | TANK IKBKE BIRC3 TRAF2 | Toll-like Receptor Cascades |
| REAC:R-HSA-933541 | 2.57219421737e-05 | 0.5 | TANK IKBKE TRAF2 | TRAF6 mediated IRF7 activation |
| GO:0071345 | 3.2238979485e-05 | 1.0 | TRAF1 BIRC3 TANK TRAF2 IKBKE HTRA2 | cellular response to cytokine stimulus |
| REAC:R-HSA-5357956 | 3.48992434538e-05 | 0.5 | TRAF2 BIRC3 TRAF1 | TNFR1-induced NF-kappa-B signaling pathway |
| CORUM:5210 | 5.12534978153e-05 | 0.333333333333 | TANK TRAF2 | TANK-TRAF2-TRAF3 complex |
| GO:0034097 | 6.56123347523e-05 | 1.0 | TRAF1 BIRC3 TANK TRAF2 IKBKE HTRA2 | response to cytokine |
| WP:WP3865 | 6.78763147219e-05 | 0.5 | TANK IKBKE TRAF2 | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04622 | 8.60988412763e-05 | 0.5 | TANK IKBKE TRAF2 | RIG-I-like receptor signaling pathway |
| KEGG:04064 | 0.000161573016829 | 0.5 | TRAF2 BIRC3 TRAF1 | NF-kappa B signaling pathway |
| WP:WP254 | 0.000169701188809 | 0.5 | TRAF2 BIRC3 TRAF1 | Apoptosis |
| GO:0043122 | 0.000186039240144 | 0.833333333333 | TANK IKBKE BIRC3 TRAF1 TRAF2 | regulation of canonical NF-kappaB signal transduction |
| KEGG:05222 | 0.000201071778007 | 0.5 | TRAF2 BIRC3 TRAF1 | Small cell lung cancer |
| KEGG:04668 | 0.000271571764431 | 0.5 | TRAF2 BIRC3 TRAF1 | TNF signaling pathway |
| WP:WP4658 | 0.0003090931252 | 0.5 | TRAF2 BIRC3 TRAF1 | Small cell lung cancer |
| GO:0007249 | 0.000311676254469 | 0.833333333333 | TANK IKBKE BIRC3 TRAF1 TRAF2 | canonical NF-kappaB signal transduction |
| REAC:R-HSA-168928 | 0.000471972525246 | 0.5 | TANK IKBKE TRAF2 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| CORUM:5212 | 0.000477929626316 | 0.333333333333 | TANK TRAF2 | Kinase maturation complex 2 |
| WP:WP5182 | 0.000914914863609 | 0.333333333333 | TRAF2 BIRC3 | Pro survival signaling of neuroprotectin D1 |
| REAC:R-HSA-5676594 | 0.0014177632075 | 0.333333333333 | TRAF2 BIRC3 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| CORUM:6344 | 0.00155157094875 | 0.333333333333 | TRAF2 BIRC3 | TNF-R1-associated signaling complex |
| GO:0019221 | 0.00167744030703 | 0.833333333333 | TANK IKBKE BIRC3 TRAF1 TRAF2 | cytokine-mediated signaling pathway |
| REAC:R-HSA-9013973 | 0.00170100530318 | 0.333333333333 | TANK IKBKE | TICAM1-dependent activation of IRF3/IRF7 |
| KEGG:05417 | 0.00185087448797 | 0.5 | TANK IKBKE TRAF2 | Lipid and atherosclerosis |
| REAC:R-HSA-936964 | 0.002344469338 | 0.333333333333 | TANK IKBKE | Activation of IRF3, IRF7 mediated by TBK1, IKBKE |
| KEGG:04215 | 0.00293718589778 | 0.333333333333 | HTRA2 BIRC3 | Apoptosis - multiple species |
| WP:WP4950 | 0.00326040131097 | 0.333333333333 | TRAF2 TRAF1 | 16p11 2 distal deletion syndrome |
| WP:WP5406 | 0.00379071267612 | 0.333333333333 | TRAF2 TRAF1 | 13q12 12 copy number variation |
| GO:0071356 | 0.00428601543329 | 0.666666666667 | TANK BIRC3 TRAF1 TRAF2 | cellular response to tumor necrosis factor |
| WP:WP3941 | 0.00630862924989 | 0.333333333333 | TRAF2 TRAF1 | Oxidative damage response |
| GO:0034612 | 0.00667678491958 | 0.666666666667 | TANK BIRC3 TRAF1 TRAF2 | response to tumor necrosis factor |
| GO:0071310 | 0.00868484611575 | 1.0 | TRAF1 BIRC3 TANK TRAF2 IKBKE HTRA2 | cellular response to organic substance |
| WP:WP2018 | 0.0103452582733 | 0.333333333333 | TRAF2 TRAF1 | RANKL RANK signaling pathway |
| REAC:R-HSA-5213460 | 0.0111743831709 | 0.333333333333 | TRAF2 BIRC3 | RIPK1-mediated regulated necrosis |
| REAC:R-HSA-5675482 | 0.0111743831709 | 0.333333333333 | TRAF2 BIRC3 | Regulation of necroptotic cell death |
| WP:WP5039 | 0.0132394005765 | 0.333333333333 | TANK TRAF2 | SARS CoV 2 innate immunity evasion and cell specific immune response |
| KEGG:05168 | 0.0153678589488 | 0.5 | TRAF2 BIRC3 IKBKE | Herpes simplex virus 1 infection |
| GO:1902531 | 0.0167276191802 | 1.0 | TRAF1 BIRC3 TANK TRAF2 IKBKE HTRA2 | regulation of intracellular signal transduction |
| KEGG:04657 | 0.0209831060756 | 0.333333333333 | TRAF2 IKBKE | IL-17 signaling pathway |
| KEGG:05022 | 0.0219191039446 | 0.5 | TRAF2 HTRA2 TANK | Pathways of neurodegeneration - multiple diseases |
| KEGG:05200 | 0.0272817161758 | 0.5 | TRAF2 BIRC3 TRAF1 | Pathways in cancer |
| WP:WP1772 | 0.0298411603065 | 0.333333333333 | HTRA2 BIRC3 | Apoptosis modulation and signaling |
| REAC:R-HSA-168249 | 0.0338175140237 | 0.666666666667 | TANK IKBKE BIRC3 TRAF2 | Innate Immune System |
| REAC:R-HSA-5218859 | 0.0352499509777 | 0.333333333333 | TRAF2 BIRC3 | Regulated Necrosis |
| GO:0010033 | 0.0366453483103 | 1.0 | TRAF1 BIRC3 TANK TRAF2 IKBKE HTRA2 | response to organic substance |
| GO:0065009 | 0.0411375751433 | 1.0 | TRAF1 BIRC3 TANK TRAF2 IKBKE HTRA2 | regulation of molecular function |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TRAF2 | TRAF1 | 1.0 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TRAF1 | 0.999 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TANK | TRAF2 | 0.999 | 0.148952380952 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| HTRA2 | TRAF2 | 0.994 | 0.034 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TANK | IKBKE | 0.98 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| HTRA2 | TRAF1 | 0.98 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TRAF2 | IKBKE | 0.976 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | TRAF2 | 0.969 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| BIRC3 | TRAF1 | 0.966 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HTRA2 | TANK | 0.952 | 0.096 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| BIRC3 | IKBKE | 0.892 | bioplex3_WMM WMM_only | |
| TRAF1 | IKBKE | 0.796 | bioplex3_WMM WMM_only | |
| HTRA2 | IKBKE | 0.451 | bioplex3_WMM WMM_only | |
| BIRC3 | TANK | 0.384 | bioplex3_WMM WMM_only | |
| BIRC3 | HTRA2 | 0.306 | bioplex3_WMM WMM_only |
Related Complexes