hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02553.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
THOC5	THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90)	5	UniProt NCBI
POLDIP3	Polymerase delta-interacting protein 3 (46 kDa DNA polymerase delta interaction protein) (p46) (S6K1 Aly/REF-like target) (SKAR)	5	UniProt NCBI
CCDC9B	Coiled-coil domain-containing protein 9B	3	UniProt NCBI
C19orf47	Uncharacterized protein C19orf47	3	UniProt NCBI
ALKBH5	RNA demethylase ALKBH5 (EC 1.14.11.53) (Alkylated DNA repair protein alkB homolog 5) (Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5)	5	UniProt NCBI
THOC1	THO complex subunit 1 (Tho1) (Nuclear matrix protein p84) (p84N5) (hTREX84)	5	UniProt NCBI
RBM27	RNA-binding protein 27 (RNA-binding motif protein 27)	4	UniProt NCBI
THOC7	THO complex subunit 7 homolog (Functional spliceosome-associated protein 24) (fSAP24) (Ngg1-interacting factor 3-like protein 1-binding protein 1) (NIF3L1-binding protein 1) (hTREX30)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:774	9.81744484776e-08	0.375	THOC7 THOC5 THOC1	THO complex
CORUM:6160	1.962985025e-07	0.375	THOC7 THOC5 THOC1	hTREX84 complex
CORUM:770	3.43434208394e-07	0.375	THOC7 THOC5 THOC1	TREX complex
REAC:R-HSA-72187	2.64339217392e-06	0.5	THOC1 THOC7 THOC5 POLDIP3	mRNA 3'-end processing
GO:0006406	4.45953644609e-06	0.625	ALKBH5 THOC7 THOC1 THOC5 POLDIP3	mRNA export from nucleus
REAC:R-HSA-73856	4.60867685367e-06	0.5	THOC1 THOC7 THOC5 POLDIP3	RNA Polymerase II Transcription Termination
GO:0051028	6.97460549517e-06	0.625	ALKBH5 THOC7 THOC1 THOC5 POLDIP3	mRNA transport
REAC:R-HSA-159236	7.08314138735e-06	0.5	THOC1 THOC7 THOC5 POLDIP3	Transport of Mature mRNA derived from an Intron-Containing Transcript
REAC:R-HSA-72202	1.15840936011e-05	0.5	THOC1 THOC7 THOC5 POLDIP3	Transport of Mature Transcript to Cytoplasm
GO:0006405	1.63146572742e-05	0.625	ALKBH5 THOC7 THOC1 THOC5 POLDIP3	RNA export from nucleus
GO:0050657	5.26755683344e-05	0.625	ALKBH5 THOC7 THOC1 THOC5 POLDIP3	nucleic acid transport
GO:0050658	5.26755683344e-05	0.625	ALKBH5 THOC7 THOC1 THOC5 POLDIP3	RNA transport
GO:0051236	6.06133240146e-05	0.625	ALKBH5 THOC7 THOC1 THOC5 POLDIP3	establishment of RNA localization
GO:0000347	0.00010757157937	0.375	THOC7 THOC5 THOC1	THO complex
GO:0000445	0.00010757157937	0.375	THOC7 THOC5 THOC1	THO complex part of transcription export complex
GO:0044417	0.0001882019462	0.375	THOC7 THOC5 THOC1	translocation of molecules into host
GO:0046784	0.0001882019462	0.375	THOC7 THOC5 THOC1	viral mRNA export from host cell nucleus
GO:0006403	0.000205434260489	0.625	ALKBH5 THOC7 THOC1 THOC5 POLDIP3	RNA localization
GO:0051168	0.000220684139706	0.625	ALKBH5 THOC7 THOC1 THOC5 POLDIP3	nuclear export
GO:0015931	0.000281322020506	0.625	ALKBH5 THOC7 THOC1 THOC5 POLDIP3	nucleobase-containing compound transport
KEGG:03013	0.000866047705047	0.375	THOC7 THOC5 THOC1	Nucleocytoplasmic transport
GO:0000346	0.000886327111509	0.375	THOC7 THOC5 THOC1	transcription export complex
REAC:R-HSA-72203	0.00169661698674	0.5	THOC1 THOC7 THOC5 POLDIP3	Processing of Capped Intron-Containing Pre-mRNA
GO:0006913	0.0032118325422	0.625	ALKBH5 THOC7 THOC1 THOC5 POLDIP3	nucleocytoplasmic transport
GO:0051169	0.0032118325422	0.625	ALKBH5 THOC7 THOC1 THOC5 POLDIP3	nuclear transport
CORUM:351	0.00397822087206	0.375	THOC7 THOC5 THOC1	Spliceosome

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
THOC7	THOC1	1.0	0.55	hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction
THOC5	THOC1	1.0	0.946	hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 fraction
THOC7	THOC5	1.0	0.522	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () Malo fraction
POLDIP3	THOC5	0.998	0.25	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
POLDIP3	THOC7	0.997	0.3	hein_WMM bioplex3_WMM youn_WMM hein ()
POLDIP3	THOC1	0.997	0.526	hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM
THOC1	RBM27	0.995	0.298	hein_WMM youn () bioplex_WMM bioplex3_WMM youn_WMM hein () fraction
POLDIP3	ALKBH5	0.994	0.164	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
THOC7	RBM27	0.981	0.092	hein_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction
ALKBH5	THOC1	0.977	0.052	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ALKBH5	RBM27	0.974	0.05	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
CCDC9B	THOC1	0.966	0.056	hein_WMM hein ()
C19orf47	THOC1	0.965	0.192	hein_WMM hein ()
C19orf47	THOC5	0.963	0.242	hein_WMM hein ()
THOC7	ALKBH5	0.939	0.062	hein_WMM bioplex_WMM bioplex3_WMM hein ()
THOC7	CCDC9B	0.934	0.05	hein_WMM hein ()
THOC5	RBM27	0.926	0.2	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
THOC7	C19orf47	0.921	0.21	hein_WMM bioplex3_HEK293 bioplex () bioplex3_WMM hein ()
POLDIP3	RBM27	0.902	0.29	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
THOC5	ALKBH5	0.86	0.09	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
C19orf47	CCDC9B	0.781	0.08	hein_WMM WMM_only
CCDC9B	RBM27	0.781	0.066	hein_WMM WMM_only
POLDIP3	C19orf47	0.729	0.23	hein_WMM gupta_WMM WMM_only
THOC5	CCDC9B	0.641	0.046	hein_WMM WMM_only
POLDIP3	CCDC9B	0.536	0.074	hein_WMM WMM_only treiber_WMM
CCDC9B	ALKBH5	0.248	0.072	hein_WMM WMM_only
C19orf47	ALKBH5	0.192	0.136	hein_WMM WMM_only
C19orf47	RBM27	0.192	0.22	hein_WMM gupta_WMM WMM_only

Related Complexes

Genename	Complexes
THOC5	huMAP3_02553.1 huMAP3_02771.1 huMAP3_04932.1 huMAP3_05846.1 huMAP3_07273.1 huMAP3_08111.1 huMAP3_08233.1 huMAP3_08963.1 huMAP3_09101.1 huMAP3_09226.1 huMAP3_09583.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
POLDIP3	huMAP3_00031.1 huMAP3_02553.1 huMAP3_04023.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06628.1 huMAP3_07273.1 huMAP3_08159.1 huMAP3_08904.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09643.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
CCDC9B	huMAP3_02553.1 huMAP3_02771.1 huMAP3_03454.1 huMAP3_05165.1 huMAP3_07755.1 huMAP3_08111.1 huMAP3_08233.1 huMAP3_08963.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09583.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
C19orf47	huMAP3_02179.1 huMAP3_02553.1 huMAP3_02771.1 huMAP3_03454.1 huMAP3_05165.1 huMAP3_07273.1 huMAP3_07755.1 huMAP3_08111.1 huMAP3_08233.1 huMAP3_08340.1 huMAP3_08963.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09457.1 huMAP3_09507.1 huMAP3_09583.1 huMAP3_10299.1 huMAP3_10359.1 huMAP3_10789.1 huMAP3_12548.1
ALKBH5	huMAP3_02553.1 huMAP3_04023.1 huMAP3_04872.1 huMAP3_05165.1 huMAP3_06628.1 huMAP3_07273.1 huMAP3_07755.1 huMAP3_08111.1 huMAP3_08159.1 huMAP3_08233.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09583.1 huMAP3_09643.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
THOC1	huMAP3_02553.1 huMAP3_02771.1 huMAP3_03454.1 huMAP3_04932.1 huMAP3_05165.1 huMAP3_07273.1 huMAP3_07755.1 huMAP3_08111.1 huMAP3_08233.1 huMAP3_08963.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09583.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1
RBM27	huMAP3_02553.1 huMAP3_05165.1 huMAP3_06678.1 huMAP3_07273.1 huMAP3_07755.1 huMAP3_08111.1 huMAP3_08233.1 huMAP3_08786.1 huMAP3_08893.1 huMAP3_09155.1 huMAP3_09583.1 huMAP3_09852.1 huMAP3_10150.1 huMAP3_10299.1 huMAP3_13593.1 huMAP3_14804.1
THOC7	huMAP3_02019.1 huMAP3_02553.1 huMAP3_04872.1 huMAP3_04932.1 huMAP3_06628.1 huMAP3_07273.1 huMAP3_08111.1 huMAP3_08159.1 huMAP3_08233.1 huMAP3_09101.1 huMAP3_09184.1 huMAP3_09225.1 huMAP3_09943.1 huMAP3_10299.1 huMAP3_10789.1 huMAP3_12548.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_02553.1