hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02554.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UBE2I | SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18) | 5 | UniProt NCBI |
| SUMO2 | Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B) | 5 | UniProt NCBI |
| SAE1 | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | 5 | UniProt NCBI |
| SUMO3 | Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3065678 | 1.4404725005e-12 | 1.0 | SUMO3 UBE2I SUMO2 SAE1 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| REAC:R-HSA-3215018 | 1.20999690042e-11 | 1.0 | SUMO3 UBE2I SUMO2 SAE1 | Processing and activation of SUMO |
| REAC:R-HSA-3065676 | 1.40306823124e-08 | 0.75 | SAE1 SUMO2 SUMO3 | SUMO is conjugated to E1 (UBA2:SAE1) |
| REAC:R-HSA-3232118 | 6.38068337719e-07 | 0.75 | UBE2I SUMO2 SUMO3 | SUMOylation of transcription factors |
| REAC:R-HSA-4090294 | 9.53498684462e-07 | 0.75 | UBE2I SUMO2 SUMO3 | SUMOylation of intracellular receptors |
| REAC:R-HSA-2990846 | 2.72176702781e-06 | 1.0 | SUMO3 UBE2I SUMO2 SAE1 | SUMOylation |
| GO:0016925 | 8.97405436883e-06 | 1.0 | SUMO3 UBE2I SUMO2 SAE1 | protein sumoylation |
| REAC:R-HSA-3899300 | 1.18162330858e-05 | 0.75 | UBE2I SUMO2 SUMO3 | SUMOylation of transcription cofactors |
| REAC:R-HSA-4615885 | 1.60766305396e-05 | 0.75 | UBE2I SUMO2 SUMO3 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-5696395 | 1.60766305396e-05 | 0.75 | UBE2I SUMO2 SUMO3 | Formation of Incision Complex in GG-NER |
| KEGG:03013 | 5.69208231113e-05 | 0.75 | UBE2I SUMO2 SUMO3 | Nucleocytoplasmic transport |
| REAC:R-HSA-4551638 | 6.40033583955e-05 | 0.75 | UBE2I SUMO2 SUMO3 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-3108214 | 7.99206750774e-05 | 0.75 | UBE2I SUMO2 SUMO3 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-5696399 | 0.000128399139144 | 0.75 | UBE2I SUMO2 SUMO3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-3065679 | 0.000153732433522 | 0.5 | SUMO3 SUMO2 | SUMO is proteolytically processed |
| GO:0018205 | 0.000195074084076 | 1.0 | SUMO3 UBE2I SUMO2 SAE1 | peptidyl-lysine modification |
| REAC:R-HSA-5696398 | 0.000284930280132 | 0.75 | UBE2I SUMO2 SUMO3 | Nucleotide Excision Repair |
| REAC:R-HSA-4755510 | 0.000461028962628 | 0.5 | UBE2I SUMO3 | SUMOylation of immune response proteins |
| REAC:R-HSA-196791 | 0.000461028962628 | 0.5 | UBE2I SUMO2 | Vitamin D (calciferol) metabolism |
| REAC:R-HSA-3108232 | 0.000897810107574 | 0.75 | UBE2I SUMO2 SUMO3 | SUMO E3 ligases SUMOylate target proteins |
| WP:WP5362 | 0.00299043061896 | 0.5 | UBE2I SUMO2 | TAR syndrome |
| HPA:0470673 | 0.0039388821921 | 0.75 | SAE1 SUMO2 SUMO3 | skin 2; melanocytes[High] |
| REAC:R-HSA-4085377 | 0.00507136546841 | 0.5 | UBE2I SUMO2 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-73894 | 0.00653220236003 | 0.75 | UBE2I SUMO2 SUMO3 | DNA Repair |
| REAC:R-HSA-597592 | 0.0091733555377 | 1.0 | SUMO3 UBE2I SUMO2 SAE1 | Post-translational protein modification |
| REAC:R-HSA-4570464 | 0.00922347264132 | 0.5 | UBE2I SUMO2 | SUMOylation of RNA binding proteins |
| HPA:0460182 | 0.0136756650941 | 0.75 | SAE1 SUMO2 SUMO3 | skin 1; cells in granular layer[>=Medium] |
| KEGG:05418 | 0.0168426929383 | 0.5 | SUMO3 SUMO2 | Fluid shear stress and atherosclerosis |
| HPA:0470202 | 0.0206978936317 | 0.75 | SAE1 SUMO2 SUMO3 | skin 2; endothelial cells[>=Medium] |
| GO:0016605 | 0.0218982649712 | 0.75 | UBE2I SUMO2 SUMO3 | PML body |
| HPA:0470672 | 0.0219529719185 | 0.75 | SAE1 SUMO2 SUMO3 | skin 2; melanocytes[>=Medium] |
| KEGG:04120 | 0.0224124539322 | 0.5 | UBE2I SAE1 | Ubiquitin mediated proteolysis |
| GO:0044388 | 0.0280843539964 | 0.5 | UBE2I SAE1 | small protein activating enzyme binding |
| HPA:0460181 | 0.0284745500846 | 0.75 | SAE1 SUMO2 SUMO3 | skin 1; cells in granular layer[>=Low] |
| HPA:0470181 | 0.0287284084928 | 0.75 | SAE1 SUMO2 SUMO3 | skin 2; cells in granular layer[>=Low] |
| HPA:0461453 | 0.0292462264975 | 0.5 | SUMO3 SUMO2 | skin 1; hair follicles[High] |
| HPA:0470671 | 0.0317556027822 | 0.75 | SAE1 SUMO2 SUMO3 | skin 2; melanocytes[>=Low] |
| HPA:0471493 | 0.0323185629783 | 0.5 | SUMO3 SUMO2 | skin 2; vascular mural cells[High] |
| REAC:R-HSA-392499 | 0.0339333915692 | 1.0 | SUMO3 UBE2I SUMO2 SAE1 | Metabolism of proteins |
| HPA:0461493 | 0.0366507731727 | 0.5 | SUMO3 SUMO2 | skin 1; vascular mural cells[High] |
| HPA:0471461 | 0.0392002139957 | 0.75 | SAE1 SUMO2 SUMO3 | skin 2; langerhans cells[>=Low] |
| REAC:R-HSA-5693607 | 0.0407325822829 | 0.5 | UBE2I SUMO2 | Processing of DNA double-strand break ends |
| CORUM:5756 | 0.049938562206 | 0.25 | SAE1 | SUA1-UBA2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SUMO2 | UBE2I | 0.999 | 0.436 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction |
| SAE1 | UBE2I | 0.999 | 0.294 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction |
| SUMO2 | SAE1 | 0.99 | 0.408 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction |
| UBE2I | SUMO3 | 0.988 | 0.142 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction |
| SUMO2 | SUMO3 | 0.929 | 0.33 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| SAE1 | SUMO3 | 0.928 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM fraction |
Related Complexes