hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02567.1
Complex Portal: CPX-14175
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NEK6 | Serine/threonine-protein kinase Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512) | 5 | UniProt NCBI |
| NEK9 | Serine/threonine-protein kinase Nek9 (EC 2.7.11.1) (Nercc1 kinase) (Never in mitosis A-related kinase 9) (NimA-related protein kinase 9) (NimA-related kinase 8) (Nek8) | 5 | UniProt NCBI |
| NEK7 | Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2980767 | 1.63310749402e-08 | 1.0 | NEK6 NEK9 NEK7 | Activation of NIMA Kinases NEK9, NEK6, NEK7 |
| REAC:R-HSA-3301854 | 2.5457812821e-06 | 1.0 | NEK6 NEK9 NEK7 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-2980766 | 7.56595371871e-06 | 1.0 | NEK6 NEK9 NEK7 | Nuclear Envelope Breakdown |
| REAC:R-HSA-9648025 | 0.00010924835892 | 1.0 | NEK6 NEK9 NEK7 | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-68875 | 0.000137759616152 | 1.0 | NEK6 NEK9 NEK7 | Mitotic Prophase |
| REAC:R-HSA-68877 | 0.000567791814488 | 1.0 | NEK6 NEK9 NEK7 | Mitotic Prometaphase |
| REAC:R-HSA-68886 | 0.00447254250064 | 1.0 | NEK6 NEK9 NEK7 | M Phase |
| REAC:R-HSA-69278 | 0.0112530904983 | 1.0 | NEK6 NEK9 NEK7 | Cell Cycle, Mitotic |
| REAC:R-HSA-1640170 | 0.0209648611427 | 1.0 | NEK6 NEK9 NEK7 | Cell Cycle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NEK7 | NEK9 | 0.998 | 0.044 |
mutually_exclusive (Q9HC98)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM |
| NEK6 | NEK9 | 0.998 | 0.05 |
mutually_exclusive (Q8TDX7)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NEK6 | NEK7 | 0.997 | 0.338 |
mutually_exclusive (Q8TD19)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt boldt_WMM |
Related Complexes