hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02571.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GRIN2B | Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) (N-methyl-D-aspartate receptor subunit 3) (NR3) (hNR3) | 5 | UniProt NCBI |
| GRIN2A | Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A) (hNR2A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5398 | 3.87329686614e-05 | 1.0 | GRIN2B GRIN2A | NRXN1 deletion syndrome |
| KEGG:05033 | 4.48692356747e-05 | 1.0 | GRIN2B GRIN2A | Nicotine addiction |
| WP:WP4875 | 0.000127691105477 | 1.0 | GRIN2B GRIN2A | Disruption of postsynaptic signaling by CNV |
| KEGG:05030 | 0.000133307149468 | 1.0 | GRIN2B GRIN2A | Cocaine addiction |
| WP:WP4698 | 0.000149398593408 | 1.0 | GRIN2B GRIN2A | Vitamin D sensitive calcium signaling in depression |
| REAC:R-HSA-9022699 | 0.000179419983974 | 1.0 | GRIN2B GRIN2A | MECP2 regulates neuronal receptors and channels |
| REAC:R-HSA-9617324 | 0.00023239159829 | 1.0 | GRIN2B GRIN2A | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-438066 | 0.00023239159829 | 1.0 | GRIN2B GRIN2A | Unblocking of NMDA receptors, glutamate binding and activation |
| KEGG:04720 | 0.000232637232791 | 1.0 | GRIN2B GRIN2A | Long-term potentiation |
| KEGG:05031 | 0.00025946123238 | 1.0 | GRIN2B GRIN2A | Amphetamine addiction |
| REAC:R-HSA-8849932 | 0.000261440548076 | 1.0 | GRIN2B GRIN2A | Synaptic adhesion-like molecules |
| REAC:R-HSA-9620244 | 0.000261440548076 | 1.0 | GRIN2B GRIN2A | Long-term potentiation |
| WP:WP4008 | 0.00028347425416 | 1.0 | GRIN2B GRIN2A | NO cGMP PKG mediated neuroprotection |
| WP:WP4222 | 0.000299222823835 | 1.0 | GRIN2B GRIN2A | Phosphodiesterases in neuronal function |
| WP:WP4312 | 0.00036647347272 | 1.0 | GRIN2B GRIN2A | Rett syndrome causing genes |
| WP:WP4539 | 0.000402652619272 | 1.0 | GRIN2B GRIN2A | Synaptic signaling pathways associated with autism spectrum disorder |
| KEGG:04713 | 0.000427233157076 | 1.0 | GRIN2B GRIN2A | Circadian entrainment |
| KEGG:04724 | 0.000526725810094 | 1.0 | GRIN2B GRIN2A | Glutamatergic synapse |
| KEGG:05322 | 0.000939327694667 | 1.0 | GRIN2B GRIN2A | Systemic lupus erythematosus |
| KEGG:04728 | 0.00095688522167 | 1.0 | GRIN2B GRIN2A | Dopaminergic synapse |
| REAC:R-HSA-9609736 | 0.00120125951175 | 1.0 | GRIN2B GRIN2A | Assembly and cell surface presentation of NMDA receptors |
| KEGG:05017 | 0.00125991513217 | 1.0 | GRIN2B GRIN2A | Spinocerebellar ataxia |
| GO:0022849 | 0.00140460216025 | 1.0 | GRIN2B GRIN2A | glutamate-gated calcium ion channel activity |
| REAC:R-HSA-6794361 | 0.00176856841345 | 1.0 | GRIN2B GRIN2A | Neurexins and neuroligins |
| KEGG:05034 | 0.00179249345126 | 1.0 | GRIN2B GRIN2A | Alcoholism |
| KEGG:04024 | 0.00201635192055 | 1.0 | GRIN2B GRIN2A | cAMP signaling pathway |
| KEGG:04015 | 0.00222639196581 | 1.0 | GRIN2B GRIN2A | Rap1 signaling pathway |
| REAC:R-HSA-8986944 | 0.00235467369443 | 1.0 | GRIN2B GRIN2A | Transcriptional Regulation by MECP2 |
| KEGG:04020 | 0.00239074992693 | 1.0 | GRIN2B GRIN2A | Calcium signaling pathway |
| WP:WP4549 | 0.00255169392445 | 1.0 | GRIN2B GRIN2A | Fragile X syndrome |
| WP:WP5083 | 0.00259851399646 | 1.0 | GRIN2B GRIN2A | Neuroinflammation and glutamatergic signaling |
| KEGG:04014 | 0.00273702337615 | 1.0 | GRIN2B GRIN2A | Ras signaling pathway |
| GO:0098976 | 0.0028092043205 | 1.0 | GRIN2B GRIN2A | excitatory chemical synaptic transmission |
| KEGG:04080 | 0.00282724955659 | 1.0 | GRIN2B GRIN2A | Neuroactive ligand-receptor interaction |
| REAC:R-HSA-438064 | 0.00389255927135 | 1.0 | GRIN2B GRIN2A | Post NMDA receptor activation events |
| REAC:R-HSA-6794362 | 0.00412665963139 | 1.0 | GRIN2B GRIN2A | Protein-protein interactions at synapses |
| WP:WP4223 | 0.00456751084292 | 1.0 | GRIN2B GRIN2A | Ras signaling |
| GO:0004972 | 0.00468200720083 | 1.0 | GRIN2B GRIN2A | NMDA glutamate receptor activity |
| GO:0017146 | 0.00468200720083 | 1.0 | GRIN2B GRIN2A | NMDA selective glutamate receptor complex |
| KEGG:05020 | 0.00485920816781 | 1.0 | GRIN2B GRIN2A | Prion disease |
| REAC:R-HSA-442755 | 0.00539968713673 | 1.0 | GRIN2B GRIN2A | Activation of NMDA receptors and postsynaptic events |
| KEGG:05014 | 0.00850662183301 | 1.0 | GRIN2B GRIN2A | Amyotrophic lateral sclerosis |
| KEGG:05010 | 0.0093688914925 | 1.0 | GRIN2B GRIN2A | Alzheimer disease |
| WP:WP2059 | 0.01130704739 | 1.0 | GRIN2B GRIN2A | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 0.01130704739 | 1.0 | GRIN2B GRIN2A | Alzheimer 39 s disease |
| KEGG:05022 | 0.0138982457502 | 1.0 | GRIN2B GRIN2A | Pathways of neurodegeneration - multiple diseases |
| HP:0200134 | 0.0143057533888 | 1.0 | GRIN2B GRIN2A | Epileptic encephalopathy |
| WP:WP5420 | 0.0144418640295 | 1.0 | GRIN2B GRIN2A | ADHD and autism ASD linked metabolic pathways and SNP |
| HP:0002384 | 0.0165784065192 | 1.0 | GRIN2B GRIN2A | Focal impaired awareness seizure |
| GO:1990806 | 0.0210690324038 | 1.0 | GRIN2B GRIN2A | ligand-gated ion channel signaling pathway |
| GO:0035235 | 0.0210690324038 | 1.0 | GRIN2B GRIN2A | ionotropic glutamate receptor signaling pathway |
| GO:0004970 | 0.0210690324038 | 1.0 | GRIN2B GRIN2A | glutamate-gated receptor activity |
| REAC:R-HSA-112314 | 0.0211937720117 | 1.0 | GRIN2B GRIN2A | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-112315 | 0.0350347422039 | 1.0 | GRIN2B GRIN2A | Transmission across Chemical Synapses |
| GO:0045471 | 0.0365196561665 | 1.0 | GRIN2B GRIN2A | response to ethanol |
| GO:0051968 | 0.0426062655276 | 1.0 | GRIN2B GRIN2A | positive regulation of synaptic transmission, glutamatergic |
| GO:0008066 | 0.0426062655276 | 1.0 | GRIN2B GRIN2A | glutamate receptor activity |
| CORUM:7240 | 0.0499419797295 | 0.5 | GRIN2A | CHRNA7-GRIN2A complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GRIN2B | GRIN2A | 0.99 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| GRIN2B | huMAP3_02571.1 huMAP3_12044.1 huMAP3_15079.1 |
| GRIN2A | huMAP3_02571.1 huMAP3_12044.1 huMAP3_15079.1 |