hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02581.1
Complex Portal: CPX-12814
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ORMDL3 | ORM1-like protein 3 | 5 | UniProt NCBI |
| ORMDL2 | ORM1-like protein 2 (Adoplin-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1660661 | 0.000958615342944 | 1.0 | ORMDL3 ORMDL2 | Sphingolipid de novo biosynthesis |
| GO:0035339 | 0.0028092043205 | 1.0 | ORMDL3 ORMDL2 | SPOTS complex |
| GO:0090156 | 0.0028092043205 | 1.0 | ORMDL3 ORMDL2 | intracellular sphingolipid homeostasis |
| REAC:R-HSA-428157 | 0.00449062588459 | 1.0 | ORMDL3 ORMDL2 | Sphingolipid metabolism |
| GO:1900060 | 0.00468200720083 | 1.0 | ORMDL3 ORMDL2 | negative regulation of ceramide biosynthetic process |
| GO:0017059 | 0.00702301080125 | 1.0 | ORMDL3 ORMDL2 | serine C-palmitoyltransferase complex |
| GO:0031211 | 0.00702301080125 | 1.0 | ORMDL3 ORMDL2 | endoplasmic reticulum palmitoyltransferase complex |
| GO:0090155 | 0.00702301080125 | 1.0 | ORMDL3 ORMDL2 | negative regulation of sphingolipid biosynthetic process |
| GO:0002178 | 0.016855225923 | 1.0 | ORMDL3 ORMDL2 | palmitoyltransferase complex |
| GO:2000303 | 0.0257510396046 | 1.0 | ORMDL3 ORMDL2 | regulation of ceramide biosynthetic process |
| GO:0090153 | 0.0309012475255 | 1.0 | ORMDL3 ORMDL2 | regulation of sphingolipid biosynthetic process |
| GO:1905038 | 0.0309012475255 | 1.0 | ORMDL3 ORMDL2 | regulation of membrane lipid metabolic process |
| CORUM:6982 | 0.0499419797295 | 0.5 | ORMDL3 | ORMDL3-SPTLC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ORMDL2 | ORMDL3 | 0.988 | 0.262 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
Related Complexes