hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02592.1
Complex Portal: CPX-23447
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BABAM1 | BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) | 5 | UniProt NCBI |
| ABRAXAS1 | BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A) | 5 | UniProt NCBI |
| SHMT2 | Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) | 5 | UniProt NCBI |
| C9orf85 | Uncharacterized protein C9orf85 | 2 | UniProt NCBI |
| BRCC3 | Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36) | 5 | UniProt NCBI |
| BABAM2 | BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein) | 5 | UniProt NCBI |
| ABRAXAS2 | BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0070552 | 1.13442382344e-12 | 0.714285714286 | BRCC3 ABRAXAS2 BABAM2 BABAM1 SHMT2 | BRISC complex |
| REAC:R-HSA-5689901 | 7.18420679895e-11 | 0.714285714286 | BRCC3 ABRAXAS2 BABAM2 BABAM1 ABRAXAS1 | Metalloprotease DUBs |
| GO:0070531 | 6.44235965654e-08 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | BRCA1-A complex |
| KEGG:03440 | 8.73363187371e-08 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | Homologous recombination |
| REAC:R-HSA-5693571 | 1.84539860471e-06 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | Nonhomologous End-Joining (NHEJ) |
| REAC:R-HSA-5693565 | 3.43026641569e-06 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 3.63144818167e-06 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | DNA Double Strand Break Response |
| WP:WP5380 | 5.45894923866e-06 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | 5q35 copy number variation |
| REAC:R-HSA-5688426 | 5.45947084881e-06 | 0.714285714286 | BRCC3 ABRAXAS2 BABAM2 BABAM1 ABRAXAS1 | Deubiquitination |
| REAC:R-HSA-69473 | 7.83760919267e-06 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | G2/M DNA damage checkpoint |
| GO:0070536 | 8.1295172324e-06 | 0.571428571429 | BABAM2 ABRAXAS2 SHMT2 BRCC3 | protein K63-linked deubiquitination |
| REAC:R-HSA-5693607 | 8.99263973412e-06 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | Processing of DNA double-strand break ends |
| CORUM:7114 | 2.05265451394e-05 | 0.285714285714 | ABRAXAS2 SHMT2 | ABRAXAS2-SHMT2 complex |
| GO:0007095 | 2.51307843796e-05 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | mitotic G2 DNA damage checkpoint signaling |
| REAC:R-HSA-5693567 | 3.17773652341e-05 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 3.84972396515e-05 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | Homology Directed Repair |
| REAC:R-HSA-5693532 | 8.69731520059e-05 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 8.92028515313e-05 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | G2/M Checkpoints |
| GO:0044818 | 0.000149249561323 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | mitotic G2/M transition checkpoint |
| CORUM:5400 | 0.000205125012531 | 0.285714285714 | BRCC3 BABAM2 | BRCC complex |
| GO:0031593 | 0.000288863510592 | 0.571428571429 | BABAM2 ABRAXAS2 ABRAXAS1 BRCC3 | polyubiquitin modification-dependent protein binding |
| GO:0010972 | 0.000311468173387 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | negative regulation of G2/M transition of mitotic cell cycle |
| GO:1902750 | 0.0003606237206 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | negative regulation of cell cycle G2/M phase transition |
| GO:0044773 | 0.000835286748042 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | mitotic DNA damage checkpoint signaling |
| REAC:R-HSA-69620 | 0.000842721142757 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | Cell Cycle Checkpoints |
| GO:0016579 | 0.000936913630871 | 0.571428571429 | BABAM2 ABRAXAS2 SHMT2 BRCC3 | protein deubiquitination |
| GO:0044774 | 0.0010475236298 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | mitotic DNA integrity checkpoint signaling |
| REAC:R-HSA-73894 | 0.00121626736244 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | DNA Repair |
| GO:0010389 | 0.00151291269338 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | regulation of G2/M transition of mitotic cell cycle |
| GO:0010212 | 0.0018400127105 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | response to ionizing radiation |
| GO:0070646 | 0.00211804437713 | 0.571428571429 | BABAM2 ABRAXAS2 SHMT2 BRCC3 | protein modification by small protein removal |
| GO:1902749 | 0.0023201010514 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | regulation of cell cycle G2/M phase transition |
| GO:0000077 | 0.00449874442284 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | DNA damage checkpoint signaling |
| GO:0000086 | 0.00503558984177 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | G2/M transition of mitotic cell cycle |
| GO:0031570 | 0.00625142797112 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | DNA integrity checkpoint signaling |
| GO:0044839 | 0.00717572690708 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | cell cycle G2/M phase transition |
| GO:0045739 | 0.00742193936463 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | positive regulation of DNA repair |
| GO:0007093 | 0.0084704456326 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | mitotic cell cycle checkpoint signaling |
| REAC:R-HSA-597592 | 0.0148745508598 | 0.714285714286 | BRCC3 ABRAXAS2 BABAM2 BABAM1 ABRAXAS1 | Post-translational protein modification |
| GO:1901991 | 0.0154598067374 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | negative regulation of mitotic cell cycle phase transition |
| GO:0042770 | 0.0197221628961 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | signal transduction in response to DNA damage |
| GO:0140030 | 0.0218746163137 | 0.571428571429 | BABAM2 ABRAXAS2 ABRAXAS1 BRCC3 | modification-dependent protein binding |
| REAC:R-HSA-1640170 | 0.0231929958906 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | Cell Cycle |
| GO:0000075 | 0.0260575019522 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | cell cycle checkpoint signaling |
| GO:0045930 | 0.0395494837294 | 0.571428571429 | BRCC3 BABAM2 BABAM1 ABRAXAS1 | negative regulation of mitotic cell cycle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| BABAM1 | BABAM2 | 1.0 | 0.45 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM |
| BABAM1 | ABRAXAS2 | 1.0 | 0.334 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| BABAM1 | BRCC3 | 1.0 | 0.316 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM | |
| BABAM1 | SHMT2 | 1.0 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| BRCC3 | ABRAXAS2 | 1.0 | 0.372 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM | |
| SHMT2 | BRCC3 | 0.999 | 0.122482269504 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| BRCC3 | BABAM2 | 0.998 | 0.802 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | |
| BABAM1 | ABRAXAS1 | 0.998 | 0.304 |
structurally_consistent (Q9NXR7)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| SHMT2 | ABRAXAS2 | 0.996 | 0.096 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| BABAM2 | ABRAXAS2 | 0.99 | 0.282 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| C9orf85 | ABRAXAS2 | 0.989 | 0.194 |
structurally_consistent (Q9NXR7)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| SHMT2 | BABAM2 | 0.985 | 0.136 |
structurally_consistent (Q15018)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| ABRAXAS1 | BRCC3 | 0.981 | 0.32 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| C9orf85 | BABAM1 | 0.981 | 0.08 |
mutually_exclusive (Q9NXR7)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| C9orf85 | BABAM2 | 0.959 | 0.116 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ABRAXAS1 | SHMT2 | 0.929 | 0.16 |
structurally_consistent (Q9NXR7)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ABRAXAS1 | BABAM2 | 0.867 | 0.17 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
| ABRAXAS1 | ABRAXAS2 | 0.4 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only | |
| C9orf85 | BRCC3 | 0.39 | 0.114 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| C9orf85 | SHMT2 | 0.019 | 0.116 |
structurally_consistent (Q9NXR7)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes