hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02612.1
Complex Portal: CPX-12528
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CUL7 | Cullin-7 (CUL-7) | 5 | UniProt NCBI |
| ZNF761 | Zinc finger protein 761 | 3 | UniProt NCBI |
| MRI1 | Methylthioribose-1-phosphate isomerase (M1Pi) (MTR-1-P isomerase) (EC 5.3.1.23) (Mediator of RhoA-dependent invasion) (S-methyl-5-thioribose-1-phosphate isomerase) (Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein) | 5 | UniProt NCBI |
| UBE2F | NEDD8-conjugating enzyme UBE2F (EC 2.3.2.32) (NEDD8 carrier protein UBE2F) (NEDD8 protein ligase UBE2F) (NEDD8-conjugating enzyme 2) (RING-type E3 NEDD8 transferase UBE2F) (Ubiquitin-conjugating enzyme E2 F) | 5 | UniProt NCBI |
| ZNF616 | Zinc finger protein 616 | 3 | UniProt NCBI |
| ZNF841 | Zinc finger protein 841 | 3 | UniProt NCBI |
| TP53 | Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53) | 5 | UniProt NCBI |
| CUL9 | Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6577 | 3.43434208394e-07 | 0.375 | TP53 CUL7 CUL9 | 3M complex |
| KEGG:05168 | 0.00125152052582 | 0.5 | ZNF616 TP53 ZNF761 ZNF841 | Herpes simplex virus 1 infection |
| REAC:R-HSA-8951664 | 0.0405199292649 | 0.375 | CUL7 CUL9 UBE2F | Neddylation |
| CORUM:2681 | 0.0499436884912 | 0.125 | TP53 | p53 homotetramer complex |
| CORUM:5811 | 0.0499436884912 | 0.125 | TP53 | p53-BCL2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CUL7 | CUL9 | 0.999 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TP53 | CUL9 | 0.997 | 0.658421901077 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CUL7 | TP53 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CUL9 | ZNF761 | 0.995 | 0.088 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CUL9 | ZNF616 | 0.992 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ZNF841 | CUL9 | 0.981 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| UBE2F | CUL9 | 0.98 | 0.066 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MRI1 | CUL9 | 0.965 | 0.1 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZNF616 | ZNF761 | 0.795 | bioplex3_WMM WMM_only | ||
| TP53 | ZNF761 | 0.532 | 0.51651255989 | bioplex_WMM bioplex3_WMM WMM_only | |
| CUL7 | ZNF761 | 0.436 | bioplex3_WMM WMM_only | ||
| UBE2F | ZNF841 | 0.415 | bioplex3_WMM WMM_only | ||
| ZNF841 | ZNF761 | 0.415 | bioplex3_WMM WMM_only | ||
| UBE2F | ZNF761 | 0.415 | 0.114 | bioplex3_WMM WMM_only | |
| CUL7 | ZNF616 | 0.335 | bioplex3_WMM WMM_only | ||
| UBE2F | ZNF616 | 0.274 | bioplex3_WMM WMM_only | ||
| ZNF841 | ZNF616 | 0.274 | bioplex3_WMM WMM_only | ||
| MRI1 | ZNF761 | 0.257 | 0.028 | bioplex3_WMM WMM_only | |
| MRI1 | ZNF616 | 0.24 | bioplex3_WMM WMM_only | ||
| TP53 | ZNF616 | 0.223 | bioplex3_WMM WMM_only | ||
| CUL7 | MRI1 | 0.168 | bioplex3_WMM WMM_only | ||
| CUL7 | ZNF841 | 0.078 | bioplex3_WMM WMM_only | ||
| CUL7 | UBE2F | 0.078 | bioplex3_WMM WMM_only | ||
| UBE2F | TP53 | 0.076 | 0.57310232303 | bioplex3_WMM WMM_only | |
| ZNF841 | TP53 | 0.076 | bioplex3_WMM WMM_only | ||
| MRI1 | ZNF841 | 0.03 | bioplex3_WMM WMM_only | ||
| MRI1 | UBE2F | 0.03 | 0.052 | bioplex3_WMM WMM_only | |
| MRI1 | TP53 | 0.007 | 0.600598238132 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes