hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_02648.1

Complex Portal: CPX-15805

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
RUVBL1	RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)	5	UniProt NCBI
DPCD	Protein DPCD	3	UniProt NCBI
MRGBP	MRG/MORF4L-binding protein (MRG-binding protein) (Up-regulated in colon cancer 4) (Urcc4)	5	UniProt NCBI
ACTL6A	Actin-like protein 6A (53 kDa BRG1-associated factor A) (Actin-related protein Baf53a) (ArpNbeta) (BRG1-associated factor 53A) (BAF53A) (INO80 complex subunit K)	5	UniProt NCBI
RUVBL2	RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)	5	UniProt NCBI
NOPCHAP1	NOP protein chaperone 1	3	UniProt NCBI
TNFSF13	Tumor necrosis factor ligand superfamily member 13 (A proliferation-inducing ligand) (APRIL) (TNF- and APOL-related leukocyte expressed ligand 2) (TALL-2) (TNF-related death ligand 1) (TRDL-1) (CD antigen CD256)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:528	2.61965734068e-09	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	NuA4/Tip60-HAT complex
CORUM:798	2.61965734068e-09	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	NuA4/Tip60-HAT complex A
CORUM:529	3.49230239814e-09	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	NuA4/Tip60-HAT complex
CORUM:1173	7.02338504734e-09	0.428571428571	ACTL6A RUVBL1 RUVBL2	TIP49-TIP48-BAF53 complex
CORUM:525	7.02050133195e-08	0.428571428571	ACTL6A RUVBL1 RUVBL2	TIP60 histone acetylase complex
CORUM:1170	7.02050133195e-08	0.428571428571	ACTL6A RUVBL1 RUVBL2	c-MYC-ATPase-helicase complex
CORUM:1171	7.02050133195e-08	0.428571428571	ACTL6A RUVBL1 RUVBL2	c-MYC-ATPase-helicase complex
CORUM:1166	1.4038119659e-07	0.428571428571	ACTL6A RUVBL1 RUVBL2	p400-associated complex
GO:0045911	2.8866785733e-07	0.714285714286	MRGBP RUVBL2 TNFSF13 RUVBL1 ACTL6A	positive regulation of DNA recombination
CORUM:787	3.92905941962e-07	0.428571428571	ACTL6A RUVBL1 RUVBL2	NuA4/Tip60-HAT complex B
CORUM:799	8.41595542506e-07	0.428571428571	ACTL6A RUVBL1 RUVBL2	DMAP1-associated complex
CORUM:304	8.41595542506e-07	0.428571428571	ACTL6A RUVBL1 RUVBL2	SRCAP-associated chromatin remodeling complex
CORUM:302	1.54229147311e-06	0.428571428571	ACTL6A RUVBL1 RUVBL2	INO80 chromatin remodeling complex
CORUM:2857	2.55074322511e-06	0.428571428571	ACTL6A RUVBL1 RUVBL2	NuA4/Tip60 HAT complex
KEGG:03082	4.34806074029e-06	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	ATP-dependent chromatin remodeling
GO:0000018	1.55760174675e-05	0.714285714286	MRGBP RUVBL2 TNFSF13 RUVBL1 ACTL6A	regulation of DNA recombination
GO:0035267	1.87820507464e-05	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	NuA4 histone acetyltransferase complex
GO:0043189	1.87820507464e-05	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	H4/H2A histone acetyltransferase complex
GO:1905168	3.75057231239e-05	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	positive regulation of double-strand break repair via homologous recombination
REAC:R-HSA-3214847	3.84972396515e-05	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	HATs acetylate histones
GO:1902562	0.000102438985779	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	H4 histone acetyltransferase complex
GO:0000492	0.000282244947588	0.428571428571	RUVBL2 RUVBL1 NOPCHAP1	box C/D snoRNP assembly
REAC:R-HSA-4839726	0.000544540630676	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	Chromatin organization
REAC:R-HSA-3247509	0.000544540630676	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	Chromatin modifying enzymes
GO:0000491	0.000554182028596	0.428571428571	RUVBL2 RUVBL1 NOPCHAP1	small nucleolar ribonucleoprotein complex assembly
GO:0010569	0.000617288463902	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	regulation of double-strand break repair via homologous recombination
CORUM:781	0.000737776422886	0.285714285714	RUVBL2 RUVBL1	URI complex (Unconventional prefoldin RPB5 Interactor)
CORUM:2856	0.000922010129722	0.285714285714	ACTL6A RUVBL1	NuA4/Tip60 HAT complex
GO:0051054	0.00114690182955	0.714285714286	MRGBP RUVBL2 TNFSF13 RUVBL1 ACTL6A	positive regulation of DNA metabolic process
GO:2000781	0.00129775343676	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	positive regulation of double-strand break repair
GO:0006310	0.00135274447935	0.714285714286	MRGBP RUVBL2 TNFSF13 RUVBL1 ACTL6A	DNA recombination
GO:0000786	0.00136674157899	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	nucleosome
GO:1904507	0.00152694380207	0.428571428571	ACTL6A RUVBL1 RUVBL2	positive regulation of telomere maintenance in response to DNA damage
GO:0031011	0.00187892941497	0.428571428571	ACTL6A RUVBL1 RUVBL2	Ino80 complex
GO:0000123	0.00211804437713	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	histone acetyltransferase complex
GO:0060382	0.00228108846854	0.428571428571	ACTL6A RUVBL1 RUVBL2	regulation of DNA strand elongation
GO:1904505	0.00273674384085	0.428571428571	ACTL6A RUVBL1 RUVBL2	regulation of telomere maintenance in response to DNA damage
GO:1902493	0.00327560699829	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	acetyltransferase complex
GO:0031248	0.00327560699829	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	protein acetyltransferase complex
WP:WP2361	0.00531562340489	0.285714285714	ACTL6A RUVBL1	Gastric cancer network 1
GO:0045739	0.00742193936463	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	positive regulation of DNA repair
GO:2000779	0.00742193936463	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	regulation of double-strand break repair
REAC:R-HSA-171319	0.00959557699108	0.285714285714	RUVBL2 RUVBL1	Telomere Extension By Telomerase
GO:0043247	0.00979189312029	0.428571428571	ACTL6A RUVBL1 RUVBL2	telomere maintenance in response to DNA damage
GO:0097346	0.00979189312029	0.428571428571	ACTL6A RUVBL1 RUVBL2	INO80-type complex
GO:0051052	0.0182760903465	0.714285714286	MRGBP RUVBL2 TNFSF13 RUVBL1 ACTL6A	regulation of DNA metabolic process
GO:0000724	0.0224390732175	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	double-strand break repair via homologous recombination
GO:0000725	0.0248063154794	0.571428571429	MRGBP RUVBL2 RUVBL1 ACTL6A	recombinational repair
GO:0022616	0.0259578682575	0.428571428571	ACTL6A RUVBL1 RUVBL2	DNA strand elongation
REAC:R-HSA-5696394	0.0265716665994	0.285714285714	ACTL6A RUVBL1	DNA Damage Recognition in GG-NER
HPA:0570762	0.0297218581462	0.714285714286	DPCD RUVBL2 ACTL6A RUVBL1 MRGBP	testis; pachytene spermatocytes[>=Medium]
HPA:0570793	0.0331675907289	0.571428571429	DPCD RUVBL2 ACTL6A MRGBP	testis; round or early spermatids[High]
REAC:R-HSA-180786	0.0480490075434	0.285714285714	RUVBL2 RUVBL1	Extension of Telomeres

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
RUVBL1	RUVBL2	1.0	0.998	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM
RUVBL1	MRGBP	0.999	0.318		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
RUVBL1	NOPCHAP1	0.998	0.526	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM boldt_WMM
MRGBP	ACTL6A	0.998	0.136		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 fraction
ACTL6A	RUVBL2	0.998	0.38		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 fraction treiber_WMM
RUVBL1	DPCD	0.998	0.378		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM
DPCD	RUVBL2	0.997	0.342	structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM
MRGBP	RUVBL2	0.997	0.344		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
RUVBL1	ACTL6A	0.996	0.356		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 treiber_WMM
DPCD	TNFSF13	0.996			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
RUVBL2	NOPCHAP1	0.991	0.58	structurally_consistent (Q9Y265)	hein_WMM bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM boldt_WMM
RUVBL2	TNFSF13	0.982			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
RUVBL1	TNFSF13	0.974			bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
ACTL6A	NOPCHAP1	0.974	0.068		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
MRGBP	NOPCHAP1	0.967	0.084		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
DPCD	NOPCHAP1	0.945	0.108		hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only
DPCD	MRGBP	0.569	0.05		hein_WMM bioplex_WMM bioplex3_WMM WMM_only
DPCD	ACTL6A	0.195	0.07		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ACTL6A	TNFSF13	0.002			bioplex3_HCT116 WMM_only

Related Complexes

Genename	Complexes
RUVBL1	huMAP3_02648.1 huMAP3_06881.1 huMAP3_07843.1 huMAP3_09291.1 huMAP3_10481.1 huMAP3_14133.1 huMAP3_14306.1
DPCD	huMAP3_02648.1 huMAP3_03251.1 huMAP3_06881.1 huMAP3_07843.1 huMAP3_09291.1 huMAP3_09612.1 huMAP3_10402.1 huMAP3_10481.1 huMAP3_10507.1 huMAP3_14133.1 huMAP3_14306.1
MRGBP	huMAP3_02648.1 huMAP3_03817.1 huMAP3_06592.1 huMAP3_07843.1 huMAP3_09291.1 huMAP3_10481.1 huMAP3_13013.1 huMAP3_14306.1
ACTL6A	huMAP3_02648.1 huMAP3_06592.1 huMAP3_07843.1 huMAP3_09291.1 huMAP3_10481.1 huMAP3_14306.1
RUVBL2	huMAP3_02648.1 huMAP3_06881.1 huMAP3_07843.1 huMAP3_09291.1 huMAP3_10481.1 huMAP3_14133.1 huMAP3_14306.1
NOPCHAP1	huMAP3_02648.1 huMAP3_06592.1 huMAP3_07843.1 huMAP3_09291.1 huMAP3_10481.1 huMAP3_14133.1 huMAP3_14306.1
TNFSF13	huMAP3_02648.1 huMAP3_03251.1 huMAP3_03914.1 huMAP3_06881.1 huMAP3_07843.1 huMAP3_09291.1 huMAP3_10402.1 huMAP3_10481.1 huMAP3_10507.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_02648.1

Complex Portal: CPX-15805