hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02666.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PPP4R3A | Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1) | 5 | UniProt NCBI |
| PPP4R3B | Serine/threonine-protein phosphatase 4 regulatory subunit 3B (SMEK homolog 2) | 5 | UniProt NCBI |
| DHX38 | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (EC 3.6.4.13) (ATP-dependent RNA helicase DHX38) (DEAH box protein 38) | 5 | UniProt NCBI |
| CT45A7 | Cancer/testis antigen family 45 member A7 (Cancer/testis antigen 45A7) | 2 | UniProt NCBI |
| CT45A9 | Cancer/testis antigen family 45 member A9 (Cancer/testis antigen 45A9) | 1 | UniProt NCBI |
| PPP4R2 | Serine/threonine-protein phosphatase 4 regulatory subunit 2 | 5 | UniProt NCBI |
| CT45A10 | Cancer/testis antigen family 45 member A10 (Cancer/testis antigen 45A10) | 2 | UniProt NCBI |
| PTPA | Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B') | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030289 | 5.37995977657e-05 | 0.375 | PPP4R3A PPP4R3B PPP4R2 | protein phosphatase 4 complex |
| GO:0008287 | 0.000419928845551 | 0.5 | PPP4R3A PPP4R3B PTPA PPP4R2 | protein serine/threonine phosphatase complex |
| GO:1903293 | 0.000419928845551 | 0.5 | PPP4R3A PPP4R3B PTPA PPP4R2 | phosphatase complex |
| WP:WP4949 | 0.000551678502006 | 0.375 | PPP4R3A PPP4R3B PPP4R2 | 16p11 2 proximal deletion syndrome |
| GO:0019888 | 0.00101449748273 | 0.5 | PPP4R3A PPP4R3B PTPA PPP4R2 | protein phosphatase regulator activity |
| GO:0072542 | 0.00153551162834 | 0.375 | PPP4R3A PPP4R3B PTPA | protein phosphatase activator activity |
| TF:M02044_1 | 0.0018258515155 | 0.875 | CT45A9 CT45A10 CT45A7 PPP4R2 PTPA DHX38 PPP4R3A | Factor: YY1; motif: GCCGCCATTTTG; match class: 1 |
| GO:0019208 | 0.00186685265625 | 0.5 | PPP4R3A PPP4R3B PTPA PPP4R2 | phosphatase regulator activity |
| GO:0019211 | 0.00195378579303 | 0.375 | PPP4R3A PPP4R3B PTPA | phosphatase activator activity |
| TF:M01035_1 | 0.040931720558 | 0.75 | CT45A9 CT45A7 CT45A10 PPP4R2 PTPA PPP4R3A | Factor: YY1; motif: NYNKCCATNTT; match class: 1 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PPP4R3B | PPP4R2 | 1.0 | 0.034 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| PPP4R3A | PPP4R2 | 1.0 | 0.526 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| PPP4R2 | PTPA | 0.998 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PPP4R3A | PPP4R3B | 0.997 | 0.09 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| PPP4R3A | PTPA | 0.997 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PPP4R3A | DHX38 | 0.992 | 0.648 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 gupta_WMM |
| PPP4R3B | CT45A7 | 0.99 | 0.042 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| CT45A9 | PPP4R2 | 0.988 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PPP4R3A | CT45A7 | 0.982 | 0.09 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| CT45A7 | CT45A9 | 0.982 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CT45A7 | PPP4R2 | 0.981 | 0.072 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| DHX38 | PPP4R2 | 0.979 | 0.114 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| PPP4R2 | CT45A10 | 0.966 | hein_WMM hein () | |
| PPP4R3A | CT45A10 | 0.895 | hein_WMM hein () | |
| PPP4R3A | CT45A9 | 0.796 | bioplex3_WMM WMM_only | |
| PPP4R3B | CT45A9 | 0.796 | bioplex3_WMM WMM_only | |
| PPP4R3B | PTPA | 0.742 | 0.052 | bioplex_WMM bioplex3_WMM WMM_only |
| PPP4R3B | DHX38 | 0.627 | 0.104 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| CT45A7 | PTPA | 0.448 | 0.086 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| DHX38 | CT45A10 | 0.423 | hein_WMM WMM_only | |
| CT45A9 | PTPA | 0.261 | bioplex3_WMM WMM_only | |
| DHX38 | CT45A9 | 0.099 | bioplex3_WMM WMM_only | |
| PPP4R3B | CT45A10 | 0.063 | hein_WMM WMM_only | |
| DHX38 | PTPA | 0.007 | 0.076 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes