List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_02691.1

Confidence: Extremely High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
LDB1	LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (hLdb1) (Nuclear LIM interactor)	5	UniProt   NCBI
SSBP2	Single-stranded DNA-binding protein 2 (Sequence-specific single-stranded-DNA-binding protein 2)	4	UniProt   NCBI
LHX4	LIM/homeobox protein Lhx4 (LIM homeobox protein 4)	5	UniProt   NCBI
LHX1	LIM/homeobox protein Lhx1 (LIM homeobox protein 1) (Homeobox protein Lim-1) (hLim-1)	5	UniProt   NCBI
LMO4	LIM domain transcription factor LMO4 (Breast tumor autoantigen) (LIM domain only protein 4) (LMO-4)	5	UniProt   NCBI
LMX1B	LIM homeobox transcription factor 1-beta (LIM/homeobox protein 1.2) (LMX-1.2) (LIM/homeobox protein LMX1B)	5	UniProt   NCBI
IDI2	Isopentenyl-diphosphate delta-isomerase 2 (EC 5.3.3.2) (Isopentenyl pyrophosphate isomerase 2) (IPP isomerase 2) (IPPI2)	5	UniProt   NCBI
SSBP4	Single-stranded DNA-binding protein 4	3	UniProt   NCBI
ISL2	Insulin gene enhancer protein ISL-2 (Islet-2)	4	UniProt   NCBI
LHX3	LIM/homeobox protein Lhx3 (LIM homeobox protein 3)	5	UniProt   NCBI
LHX6	LIM/homeobox protein Lhx6 (LIM homeobox protein 6) (LIM/homeobox protein Lhx6.1)	5	UniProt   NCBI
ISL1	Insulin gene enhancer protein ISL-1 (Islet-1)	5	UniProt   NCBI
LHX2	LIM/homeobox protein Lhx2 (Homeobox protein LH-2) (LIM homeobox protein 2)	5	UniProt   NCBI
LHX9	LIM/homeobox protein Lhx9 (LIM homeobox protein 9)	5	UniProt   NCBI
LMO1	Rhombotin-1 (Cysteine-rich protein TTG-1) (LIM domain only protein 1) (LMO-1) (T-cell translocation protein 1)	5	UniProt   NCBI
SSBP3	Single-stranded DNA-binding protein 3 (Sequence-specific single-stranded-DNA-binding protein)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-9010553	2.70040803926e-06	0.4	ISL1 LHX2 LHX9 LDB1 LHX3 LHX4	Regulation of expression of SLITs and ROBOs
GO:0006357	3.30528816231e-06	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	regulation of transcription by RNA polymerase II
GO:0006366	6.53102604937e-06	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	transcription by RNA polymerase II
REAC:R-HSA-376176	1.10230603102e-05	0.4	ISL1 LHX2 LHX9 LDB1 LHX3 LHX4	Signaling by ROBO receptors
GO:0030182	1.19517020939e-05	0.666666666667	ISL1 LHX4 LHX1 LMX1B ISL2 LHX9 LDB1 LHX3 LHX6 LHX2	neuron differentiation
GO:0045893	1.32002828977e-05	0.733333333333	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LDB1 SSBP2 SSBP3 SSBP4 LHX3	positive regulation of DNA-templated transcription
GO:1902680	1.36118051669e-05	0.733333333333	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LDB1 SSBP2 SSBP3 SSBP4 LHX3	positive regulation of RNA biosynthetic process
GO:0048699	2.05885902477e-05	0.666666666667	ISL1 LHX4 LHX1 LMX1B ISL2 LHX9 LDB1 LHX3 LHX6 LHX2	generation of neurons
GO:0051254	4.4994803313e-05	0.733333333333	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LDB1 SSBP2 SSBP3 SSBP4 LHX3	positive regulation of RNA metabolic process
GO:0022008	7.74517333966e-05	0.666666666667	ISL1 LHX4 LHX1 LMX1B ISL2 LHX9 LDB1 LHX3 LHX6 LHX2	neurogenesis
GO:0006355	0.000142975581708	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	regulation of DNA-templated transcription
GO:0007399	0.000150937749373	0.733333333333	ISL1 LHX4 LHX1 LMX1B ISL2 LHX9 LDB1 LHX3 LHX6 LMO4 LHX2	nervous system development
GO:2001141	0.000154368703652	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	regulation of RNA biosynthetic process
GO:0000785	0.000178818690039	0.666666666667	ISL1 LHX4 LHX1 LMX1B ISL2 LHX9 LDB1 LHX3 LHX6 LHX2	chromatin
GO:0045935	0.000185916085962	0.733333333333	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LDB1 SSBP2 SSBP3 SSBP4 LHX3	positive regulation of nucleobase-containing compound metabolic process
GO:0006351	0.000260605124329	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	DNA-templated transcription
CORUM:2214	0.000286035615974	0.133333333333	LDB1 LMO4	LMO4-BRCA1-CTIP-LDB1 complex
GO:0032774	0.000298346405164	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	RNA biosynthetic process
GO:0032993	0.000316967442093	0.666666666667	ISL1 LHX4 LHX1 LMX1B ISL2 LHX9 LDB1 LHX3 LHX6 LHX2	protein-DNA complex
GO:0045944	0.000506525641918	0.6	ISL1 LHX4 SSBP4 LMX1B ISL2 LDB1 SSBP2 SSBP3 LHX3	positive regulation of transcription by RNA polymerase II
GO:0051252	0.000588378992431	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	regulation of RNA metabolic process
REAC:R-HSA-422475	0.00145063178111	0.4	ISL1 LHX2 LHX9 LDB1 LHX3 LHX4	Axon guidance
GO:0034654	0.00145416647034	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	nucleobase-containing compound biosynthetic process
GO:0000981	0.00169579465389	0.6	ISL1 LHX4 LMX1B ISL2 LHX9 LHX1 LHX3 LHX6 LHX2	DNA-binding transcription factor activity, RNA polymerase II-specific
REAC:R-HSA-9675108	0.00179207880155	0.4	ISL1 LHX2 LHX9 LDB1 LHX3 LHX4	Nervous system development
GO:0018130	0.00182908891309	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	heterocycle biosynthetic process
GO:0010557	0.0018405800291	0.733333333333	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LDB1 SSBP2 SSBP3 SSBP4 LHX3	positive regulation of macromolecule biosynthetic process
GO:0019438	0.00185368644094	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	aromatic compound biosynthetic process
GO:0019219	0.00186195278483	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	regulation of nucleobase-containing compound metabolic process
GO:0031328	0.00251366974359	0.733333333333	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LDB1 SSBP2 SSBP3 SSBP4 LHX3	positive regulation of cellular biosynthetic process
GO:0031325	0.00256799451163	0.8	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LDB1 SSBP2 SSBP3 SSBP4 LMO4 LHX3	positive regulation of cellular metabolic process
GO:1901362	0.00266712285287	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	organic cyclic compound biosynthetic process
GO:0009891	0.00268861838014	0.733333333333	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LDB1 SSBP2 SSBP3 SSBP4 LHX3	positive regulation of biosynthetic process
GO:0003700	0.00290880319144	0.6	ISL1 LHX4 LMX1B ISL2 LHX9 LHX1 LHX3 LHX6 LHX2	DNA-binding transcription factor activity
GO:0000976	0.0045386952108	0.6	ISL1 LHX4 LMX1B ISL2 LHX9 LHX1 LHX3 LHX6 LHX2	transcription cis-regulatory region binding
GO:0001067	0.00457896850003	0.6	ISL1 LHX4 LMX1B ISL2 LHX9 LHX1 LHX3 LHX6 LHX2	transcription regulatory region nucleic acid binding
GO:0005694	0.00591638613995	0.666666666667	ISL1 LHX4 LHX1 LMX1B ISL2 LHX9 LDB1 LHX3 LHX6 LHX2	chromosome
WP:WP2064	0.00603033830257	0.2	LHX1 LHX2 ISL1	Neural crest differentiation
GO:1990837	0.00680671581173	0.6	ISL1 LHX4 LMX1B ISL2 LHX9 LHX1 LHX3 LHX6 LHX2	sequence-specific double-stranded DNA binding
GO:0016070	0.0099762017936	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	RNA metabolic process
GO:0009893	0.0101249467713	0.8	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LDB1 SSBP2 SSBP3 SSBP4 LMO4 LHX3	positive regulation of metabolic process
GO:0003677	0.011735120084	0.666666666667	ISL1 LHX4 LHX2 LMX1B ISL2 LHX9 LHX1 LHX3 LHX6 SSBP2	DNA binding
GO:0043565	0.0125979218594	0.6	ISL1 LHX4 LMX1B ISL2 LHX9 LHX1 LHX3 LHX6 LHX2	sequence-specific DNA binding
GO:0003690	0.012895828095	0.6	ISL1 LHX4 LMX1B ISL2 LHX9 LHX1 LHX3 LHX6 LHX2	double-stranded DNA binding
GO:0010468	0.0160805513768	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	regulation of gene expression
GO:0051173	0.0162884037275	0.733333333333	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LDB1 SSBP2 SSBP3 SSBP4 LHX3	positive regulation of nitrogen compound metabolic process
HP:0031218	0.0163481858886	0.133333333333	LHX4 LHX3	Inappropriate antidiuretic hormone secretion
HP:0000839	0.0163481858886	0.133333333333	LHX4 LHX3	Pituitary dwarfism
GO:0048731	0.0164546996009	0.733333333333	ISL1 LHX4 LHX1 LMX1B ISL2 LHX9 LDB1 LHX3 LHX6 LMO4 LHX2	system development
GO:0031323	0.0164965872097	0.933333333333	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LMO4 LHX3	regulation of cellular metabolic process
GO:0044271	0.0176385196416	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	cellular nitrogen compound biosynthetic process
GO:0010556	0.0236843562468	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	regulation of macromolecule biosynthetic process
HP:0031219	0.0304804305825	0.133333333333	LHX4 LHX3	Reduced radioactive iodine uptake
HP:0031221	0.0304804305825	0.133333333333	LHX4 LHX3	Abnormal radioactive iodine uptake test result
GO:0031326	0.0311340308956	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	regulation of cellular biosynthetic process
GO:0009889	0.0335083600236	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	regulation of biosynthetic process
REAC:R-HSA-1266738	0.0371366294753	0.4	ISL1 LHX2 LHX9 LDB1 LHX3 LHX4	Developmental Biology
HP:0031098	0.0391658859752	0.133333333333	LHX4 LHX3	Decreased thyroid-stimulating hormone level
GO:0000977	0.0433861514995	0.533333333333	ISL1 LHX4 LMX1B LHX9 LHX1 LHX3 LHX6 LHX2	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0090304	0.0459903481626	0.866666666667	ISL1 LHX4 LHX1 LHX2 LMX1B ISL2 LHX9 LDB1 SSBP2 SSBP3 LHX6 SSBP4 LHX3	nucleic acid metabolic process
HP:0008828	0.0489283265382	0.133333333333	LHX4 LHX3	Delayed proximal femoral epiphyseal ossification
GO:0097376	0.0491610756088	0.133333333333	LHX1 LHX9	interneuron axon guidance
GO:0097378	0.0491610756088	0.133333333333	LHX1 LHX9	dorsal spinal cord interneuron axon guidance
GO:0097377	0.0491610756088	0.133333333333	LHX1 LHX9	spinal cord interneuron axon guidance
CORUM:3181	0.0498224659463	0.0666666666667	LMO4	LMO4-CREB complex



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
LMO4	SSBP4	1.0	0.054
LMO4	SSBP3	1.0	0.0933333333333
SSBP2	LMO4	1.0	0.076
LMX1B	SSBP4	1.0
SSBP4	ISL2	1.0
LDB1	SSBP4	1.0
LDB1	SSBP3	1.0
SSBP2	LMX1B	1.0
ISL2	SSBP3	1.0
SSBP2	SSBP3	1.0	0.098
SSBP2	SSBP4	1.0	0.088
SSBP4	ISL1	0.999
SSBP2	ISL2	0.999
LDB1	SSBP2	0.999
SSBP4	LMO1	0.999
ISL1	SSBP3	0.999
LMX1B	SSBP3	0.999
SSBP4	SSBP3	0.999	0.154
LDB1	LMX1B	0.999
LHX2	SSBP3	0.999
SSBP2	ISL1	0.998
LHX6	SSBP4	0.998
LMX1B	ISL2	0.998
LDB1	ISL2	0.998
LHX6	SSBP3	0.998
LHX6	LDB1	0.998
LDB1	LMO1	0.997
LMO1	SSBP3	0.997
LHX6	LMX1B	0.997
SSBP2	LMO1	0.997
LHX4	SSBP4	0.995
LHX3	SSBP3	0.994
LDB1	LMO4	0.994
LMO4	LMX1B	0.993
LMO4	ISL2	0.993
LDB1	LHX4	0.992
LDB1	ISL1	0.992
ISL2	ISL1	0.992
LHX4	SSBP3	0.988
LMO4	LMO1	0.987
LMO4	ISL1	0.984
LHX3	LDB1	0.984
LHX1	SSBP4	0.984
LMX1B	ISL1	0.983
SSBP4	LHX9	0.982
IDI2	SSBP3	0.977
ISL2	LMO1	0.975
SSBP4	LHX2	0.975
LMO4	IDI2	0.974
LHX9	SSBP3	0.973
LDB1	LHX9	0.972
SSBP2	IDI2	0.972
LHX1	SSBP3	0.969
IDI2	SSBP4	0.963
LHX6	SSBP2	0.961
LDB1	IDI2	0.961
LHX3	ISL2	0.956
SSBP2	LHX4	0.94
LMX1B	LMO1	0.934
LHX3	SSBP4	0.924
LHX3	SSBP2	0.916
LMX1B	IDI2	0.904
LHX2	LMO1	0.892
LMO4	LHX2	0.855
ISL2	LHX2	0.838
LMX1B	LHX2	0.838
ISL1	LHX2	0.826
SSBP2	LHX2	0.803
LDB1	LHX2	0.791
LHX4	ISL1	0.778
LHX4	ISL2	0.773
ISL1	LMO1	0.73
LHX1	LMO4	0.575
LHX4	LMX1B	0.569
LHX1	LHX2	0.465
IDI2	ISL2	0.402
LHX4	LMO4	0.4
LHX1	ISL2	0.4
SSBP2	LHX1	0.4
LDB1	LHX1	0.4
LHX1	LMX1B	0.4
LHX4	LHX1	0.396
LHX1	ISL1	0.367
LHX1	LMO1	0.333
LHX4	LMO1	0.164
LHX4	LHX2	0.146





Related Complexes

Genename	Complexes
LDB1	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
SSBP2	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LHX4	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LHX1	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LMO4	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LMX1B	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
IDI2	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
SSBP4	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
ISL2	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LHX3	huMAP3_01557.1 huMAP3_02691.1 huMAP3_06128.1 huMAP3_09723.1 huMAP3_13541.1
LHX6	huMAP3_01166.1 huMAP3_01950.1 huMAP3_02691.1 huMAP3_05656.1 huMAP3_09723.1 huMAP3_09856.1
ISL1	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LHX2	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LHX9	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1
LMO1	huMAP3_02691.1 huMAP3_03114.1 huMAP3_09723.1 huMAP3_11722.1 huMAP3_13541.1 huMAP3_14006.1 huMAP3_14094.1
SSBP3	huMAP3_02691.1 huMAP3_09723.1 huMAP3_13541.1