hu.MAP 3.0: Complex View

Human Protein Complex Map

Genename	Protein Name	Uniprot Annotation Score	Links
SIRT6	NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) (Regulatory protein SIR2 homolog 6) (hSIRT6) (SIR2-like protein 6)	5	UniProt NCBI
GFPT2	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 2) (Glutamine:fructose-6-phosphate amidotransferase 2) (GFAT 2) (GFAT2) (Hexosephosphate aminotransferase 2)	5	UniProt NCBI
GFPT1	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase 1) (Glutamine:fructose-6-phosphate amidotransferase 1) (GFAT 1) (GFAT1) (Hexosephosphate aminotransferase 1)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-446210	0.000190864539041	0.666666666667	GFPT2 GFPT1	Synthesis of UDP-N-acetyl-glucosamine
KEGG:00250	0.000354497763776	0.666666666667	GFPT2 GFPT1	Alanine, aspartate and glutamate metabolism
KEGG:01250	0.000453521779354	0.666666666667	GFPT2 GFPT1	Biosynthesis of nucleotide sugars
KEGG:00520	0.000754254484718	0.666666666667	GFPT2 GFPT1	Amino sugar and nucleotide sugar metabolism
GO:0004360	0.00140460216025	0.666666666667	GFPT2 GFPT1	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0070548	0.00140460216025	0.666666666667	GFPT2 GFPT1	L-glutamine aminotransferase activity
KEGG:04931	0.00361241039138	0.666666666667	GFPT2 GFPT1	Insulin resistance
REAC:R-HSA-446219	0.0112421146161	0.666666666667	GFPT2 GFPT1	Synthesis of substrates in N-glycan biosythesis
KEGG:05415	0.0124702277162	0.666666666667	GFPT2 GFPT1	Diabetic cardiomyopathy
REAC:R-HSA-446193	0.0178608636553	0.666666666667	GFPT2 GFPT1	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
KEGG:01100	0.0189521995452	1.0	SIRT6 GFPT1 GFPT2	Metabolic pathways
GO:0006048	0.0393180950424	0.666666666667	GFPT2 GFPT1	UDP-N-acetylglucosamine biosynthetic process
REAC:R-HSA-4085023	0.0498224659464	0.333333333333	GFPT1	Defective GFPT1 causes CMSTA1

Protein 1	Protein 2	Score	ProteomeHD	Evidence
GFPT2	GFPT1	0.999	0.186	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM
SIRT6	GFPT1	0.991	0.14	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
SIRT6	GFPT2	0.977	0.032	bioplex3_HEK293 bioplex3_WMM bioplex () bioplex3_HCT116 bioplex_WMM