hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02706.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HPS5 | BLOC-2 complex member HPS5 (Alpha-integrin-binding protein 63) (Hermansky-Pudlak syndrome 5 protein) (Ruby-eye protein 2 homolog) (Ru2) | 5 | UniProt NCBI |
| HPS6 | BLOC-2 complex member HPS6 (Hermansky-Pudlak syndrome 6 protein) (Ruby-eye protein homolog) (Ru) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:12 | 5.12628525639e-06 | 1.0 | HPS5 HPS6 | BLOC-2 (biogenesis of lysosome-related organelles complex 2) |
| CORUM:654 | 9.39818963671e-05 | 1.0 | HPS5 HPS6 | BLOC1-BLOC2 complex |
| HP:0004866 | 0.000153788557692 | 1.0 | HPS5 HPS6 | Impaired ADP-induced platelet aggregation |
| HP:0011883 | 0.000187963792734 | 1.0 | HPS5 HPS6 | Abnormal platelet granules |
| HP:0001022 | 0.000410102820511 | 1.0 | HPS5 HPS6 | Albinism |
| HP:0001107 | 0.000717679935894 | 1.0 | HPS5 HPS6 | Ocular albinism |
| HP:0007513 | 0.00111069513888 | 1.0 | HPS5 HPS6 | Generalized hypopigmentation |
| HP:0003540 | 0.00138751454273 | 1.0 | HPS5 HPS6 | Impaired platelet aggregation |
| GO:0031084 | 0.00140460216025 | 1.0 | HPS5 HPS6 | BLOC-2 complex |
| HP:0030402 | 0.00158914842948 | 1.0 | HPS5 HPS6 | Abnormal platelet aggregation |
| HP:0008059 | 0.00203342648503 | 1.0 | HPS5 HPS6 | Aplasia/Hypoplasia of the macula |
| HP:0008061 | 0.00215303980768 | 1.0 | HPS5 HPS6 | Aplasia/Hypoplasia of the retina |
| HP:0003010 | 0.00240251902349 | 1.0 | HPS5 HPS6 | Prolonged bleeding time |
| HP:0000493 | 0.00294248773717 | 1.0 | HPS5 HPS6 | Abnormal foveal morphology |
| HP:0007730 | 0.0036943429081 | 1.0 | HPS5 HPS6 | Iris hypopigmentation |
| HP:0011869 | 0.0036943429081 | 1.0 | HPS5 HPS6 | Abnormal platelet function |
| HP:0000421 | 0.0102628230833 | 1.0 | HPS5 HPS6 | Epistaxis |
| HP:0005599 | 0.0113495955576 | 1.0 | HPS5 HPS6 | Hypopigmentation of hair |
| HP:0009887 | 0.0172584936965 | 1.0 | HPS5 HPS6 | Abnormality of hair pigmentation |
| HP:0008034 | 0.0248112206409 | 1.0 | HPS5 HPS6 | Abnormal iris pigmentation |
| HP:0008057 | 0.0273436055576 | 1.0 | HPS5 HPS6 | Aplasia/Hypoplasia affecting the fundus |
| HP:0000978 | 0.0371758206793 | 1.0 | HPS5 HPS6 | Bruising susceptibility |
| HP:0001103 | 0.0490927251387 | 1.0 | HPS5 HPS6 | Abnormal macular morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| HPS5 | HPS6 | 0.999 | 0.218 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes
| Genename | Complexes |
|---|---|
| HPS5 | huMAP3_02706.1 huMAP3_03275.1 huMAP3_08447.1 huMAP3_08728.1 huMAP3_09141.1 huMAP3_13683.1 |
| HPS6 | huMAP3_02706.1 huMAP3_03275.1 |