hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02718.1
Complex Portal: CPX-24769
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TRIT1 | tRNA dimethylallyltransferase (EC 2.5.1.75) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (hGRO1) (tRNA isopentenyltransferase 1) (IPTase) | 5 | UniProt NCBI |
| MT-ND3 | NADH-ubiquinone oxidoreductase chain 3 (EC 7.1.1.2) (NADH dehydrogenase subunit 3) | 5 | UniProt NCBI |
| NDUFS6 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial (Complex I-13kD-A) (CI-13kD-A) (NADH-ubiquinone oxidoreductase 13 kDa-A subunit) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0011923 | 9.83403274307e-05 | 1.0 | NDUFS6 TRIT1 MT-ND3 | Decreased activity of mitochondrial complex I |
| HP:0008972 | 0.000295613289572 | 1.0 | NDUFS6 TRIT1 MT-ND3 | Decreased activity of mitochondrial respiratory chain |
| HP:0011922 | 0.000324435446754 | 1.0 | NDUFS6 TRIT1 MT-ND3 | Abnormal activity of mitochondrial respiratory chain |
| HP:0003287 | 0.000760279216794 | 1.0 | NDUFS6 TRIT1 MT-ND3 | Abnormality of mitochondrial metabolism |
| HP:0012103 | 0.00112027388307 | 1.0 | NDUFS6 TRIT1 MT-ND3 | Abnormality of the mitochondrion |
| WP:WP623 | 0.00193308448658 | 0.666666666667 | NDUFS6 MT-ND3 | Oxidative phosphorylation |
| HP:0001298 | 0.00303431918859 | 1.0 | NDUFS6 TRIT1 MT-ND3 | Encephalopathy |
| CORUM:178 | 0.00308025137677 | 0.666666666667 | NDUFS6 MT-ND3 | Respiratory chain complex I (holoenzyme), mitochondrial |
| KEGG:04723 | 0.00533101781525 | 0.666666666667 | NDUFS6 MT-ND3 | Retrograde endocannabinoid signaling |
| WP:WP111 | 0.00536035090333 | 0.666666666667 | NDUFS6 MT-ND3 | Electron transport chain OXPHOS system in mitochondria |
| KEGG:00190 | 0.0056035932516 | 0.666666666667 | NDUFS6 MT-ND3 | Oxidative phosphorylation |
| HP:0012748 | 0.00667190161012 | 0.666666666667 | NDUFS6 MT-ND3 | Focal T2 hyperintense brainstem lesion |
| HP:0007704 | 0.00795970060154 | 0.666666666667 | NDUFS6 MT-ND3 | Paroxysmal involuntary eye movements |
| HP:0008316 | 0.00936084070842 | 0.666666666667 | NDUFS6 MT-ND3 | Abnormal mitochondria in muscle tissue |
| HP:0012747 | 0.00936084070842 | 0.666666666667 | NDUFS6 MT-ND3 | Abnormal brainstem MRI signal intensity |
| REAC:R-HSA-6799198 | 0.0108549519561 | 0.666666666667 | NDUFS6 MT-ND3 | Complex I biogenesis |
| KEGG:05415 | 0.0124702277162 | 0.666666666667 | NDUFS6 MT-ND3 | Diabetic cardiomyopathy |
| HP:0000114 | 0.0136509708315 | 0.666666666667 | NDUFS6 MT-ND3 | Proximal tubulopathy |
| KEGG:05208 | 0.0153557884392 | 0.666666666667 | NDUFS6 MT-ND3 | Chemical carcinogenesis - reactive oxygen species |
| KEGG:04714 | 0.0158142547588 | 0.666666666667 | NDUFS6 MT-ND3 | Thermogenesis |
| HP:0004366 | 0.0167410266547 | 0.666666666667 | NDUFS6 MT-ND3 | Abnormality of glycolysis |
| HP:0003542 | 0.0167410266547 | 0.666666666667 | NDUFS6 MT-ND3 | Increased serum pyruvate |
| HP:0001138 | 0.0173967419879 | 0.666666666667 | NDUFS6 MT-ND3 | Optic neuropathy |
| HP:0003737 | 0.0180650213362 | 0.666666666667 | NDUFS6 MT-ND3 | Mitochondrial myopathy |
| KEGG:01100 | 0.0189521995452 | 1.0 | NDUFS6 TRIT1 MT-ND3 | Metabolic pathways |
| HP:0025116 | 0.0208637442425 | 0.666666666667 | NDUFS6 MT-ND3 | Fetal distress |
| KEGG:05012 | 0.0212975456297 | 0.666666666667 | NDUFS6 MT-ND3 | Parkinson disease |
| HP:0011017 | 0.0218534403487 | 1.0 | NDUFS6 TRIT1 MT-ND3 | Abnormal cellular physiology |
| KEGG:05020 | 0.022564200016 | 0.666666666667 | NDUFS6 MT-ND3 | Prion disease |
| HP:0025354 | 0.0250749987795 | 1.0 | NDUFS6 TRIT1 MT-ND3 | Abnormal cellular phenotype |
| KEGG:05016 | 0.0275851821163 | 0.666666666667 | NDUFS6 MT-ND3 | Huntington disease |
| HP:0011013 | 0.0278951902268 | 0.666666666667 | NDUFS6 MT-ND3 | Abnormal circulating carbohydrate concentration |
| REAC:R-HSA-611105 | 0.0329299631783 | 0.666666666667 | NDUFS6 MT-ND3 | Respiratory electron transport |
| KEGG:05014 | 0.0393573532881 | 0.666666666667 | NDUFS6 MT-ND3 | Amyotrophic lateral sclerosis |
| HP:0003800 | 0.0398445800112 | 0.666666666667 | NDUFS6 MT-ND3 | Muscle abnormality related to mitochondrial dysfunction |
| KEGG:05010 | 0.0433146801558 | 0.666666666667 | NDUFS6 MT-ND3 | Alzheimer disease |
| REAC:R-HSA-163200 | 0.049233254294 | 0.666666666667 | NDUFS6 MT-ND3 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NDUFS6 | TRIT1 | 0.994 | 0.076 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| MT-ND3 | NDUFS6 | 0.974 | 0.766 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MT-ND3 | TRIT1 | 0.902 | 0.148 | bioplex3_WMM WMM_only |
Related Complexes