hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02724.1
Complex Portal: CPX-11422
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EXT1 | Exostosin-1 (EC 2.4.1.225) (Exostosin glycosyltransferase 1) (Heparan sulfate co-polymerase subunit EXT1) (Multiple exostoses protein 1) (N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase) | 5 | UniProt NCBI |
| TUBA1A | Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] | 5 | UniProt NCBI |
| TUBA1B | Tubulin alpha-1B chain (EC 3.6.5.-) (Alpha-tubulin ubiquitous) (Tubulin K-alpha-1) (Tubulin alpha-ubiquitous chain) [Cleaved into: Detyrosinated tubulin alpha-1B chain] | 5 | UniProt NCBI |
| DNAJA1 | DnaJ homolog subfamily A member 1 (DnaJ protein homolog 2) (HSDJ) (Heat shock 40 kDa protein 4) (Heat shock protein J2) (HSJ-2) (Human DnaJ protein 2) (hDj-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3371497 | 3.0932996971e-05 | 0.75 | DNAJA1 TUBA1A TUBA1B | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand |
| HPA:0471423 | 0.00152524479519 | 0.5 | TUBA1A TUBA1B | skin 2; eccrine glands[High] |
| REAC:R-HSA-190840 | 0.00156635412759 | 0.5 | TUBA1A TUBA1B | Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane |
| REAC:R-HSA-190872 | 0.00175047124894 | 0.5 | TUBA1A TUBA1B | Transport of connexons to the plasma membrane |
| HPA:0500113 | 0.00236268651237 | 0.75 | DNAJA1 TUBA1A TUBA1B | soft tissue 1; chondrocytes[High] |
| REAC:R-HSA-389977 | 0.00258893271292 | 0.5 | TUBA1A TUBA1B | Post-chaperonin tubulin folding pathway |
| WP:WP2272 | 0.00299043061896 | 0.5 | TUBA1A TUBA1B | Pathogenic Escherichia coli infection |
| REAC:R-HSA-9619483 | 0.00306932002175 | 0.5 | TUBA1A TUBA1B | Activation of AMPK downstream of NMDARs |
| REAC:R-HSA-389960 | 0.00306932002175 | 0.5 | TUBA1A TUBA1B | Formation of tubulin folding intermediates by CCT/TriC |
| REAC:R-HSA-190861 | 0.00386628370571 | 0.5 | TUBA1A TUBA1B | Gap junction assembly |
| REAC:R-HSA-9668328 | 0.00415229579539 | 0.5 | TUBA1A TUBA1B | Sealing of the nuclear envelope (NE) by ESCRT-III |
| REAC:R-HSA-5626467 | 0.00415229579539 | 0.5 | TUBA1A TUBA1B | RHO GTPases activate IQGAPs |
| REAC:R-HSA-389958 | 0.00507136546841 | 0.5 | TUBA1A TUBA1B | Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding |
| HPA:0301173 | 0.00568806346412 | 0.75 | DNAJA1 TUBA1A TUBA1B | lung; alveolar cells[High] |
| WP:WP2359 | 0.00578263137464 | 0.5 | TUBA1A TUBA1B | Parkin ubiquitin proteasomal system pathway |
| KEGG:04540 | 0.00619374956043 | 0.5 | TUBA1A TUBA1B | Gap junction |
| REAC:R-HSA-9609736 | 0.00718390333861 | 0.5 | TUBA1A TUBA1B | Assembly and cell surface presentation of NMDA receptors |
| REAC:R-HSA-8955332 | 0.00718390333861 | 0.5 | TUBA1A TUBA1B | Carboxyterminal post-translational modifications of tubulin |
| REAC:R-HSA-190828 | 0.007571530532 | 0.5 | TUBA1A TUBA1B | Gap junction trafficking |
| REAC:R-HSA-157858 | 0.0079693038543 | 0.5 | TUBA1A TUBA1B | Gap junction trafficking and regulation |
| REAC:R-HSA-9646399 | 0.00837722051003 | 0.5 | TUBA1A TUBA1B | Aggrephagy |
| HPA:0471422 | 0.00986185195675 | 0.5 | TUBA1A TUBA1B | skin 2; eccrine glands[>=Medium] |
| REAC:R-HSA-437239 | 0.0105688559686 | 0.5 | TUBA1A TUBA1B | Recycling pathway of L1 |
| REAC:R-HSA-6811436 | 0.012504459305 | 0.5 | TUBA1A TUBA1B | COPI-independent Golgi-to-ER retrograde traffic |
| HPA:0471402 | 0.0126567274704 | 0.5 | TUBA1A TUBA1B | skin 2; cells in corneal layer[>=Medium] |
| REAC:R-HSA-5620924 | 0.0130136556072 | 0.5 | TUBA1A TUBA1B | Intraflagellar transport |
| HPA:0461483 | 0.0133247573673 | 0.5 | TUBA1A TUBA1B | skin 1; sebaceous glands[High] |
| REAC:R-HSA-983189 | 0.0146019089592 | 0.5 | TUBA1A TUBA1B | Kinesins |
| HPA:0471421 | 0.0150694092342 | 0.5 | TUBA1A TUBA1B | skin 2; eccrine glands[>=Low] |
| HPA:0461423 | 0.0157970760006 | 0.5 | TUBA1A TUBA1B | skin 1; eccrine glands[High] |
| HPA:0340453 | 0.0169474947772 | 0.75 | DNAJA1 TUBA1A TUBA1B | ovary; follicle cells[High] |
| KEGG:04210 | 0.0177164397058 | 0.5 | TUBA1A TUBA1B | Apoptosis |
| KEGG:04145 | 0.0214296747035 | 0.5 | TUBA1A TUBA1B | Phagosome |
| REAC:R-HSA-2995410 | 0.022534212454 | 0.5 | TUBA1A TUBA1B | Nuclear Envelope (NE) Reassembly |
| REAC:R-HSA-438064 | 0.0232149434748 | 0.5 | TUBA1A TUBA1B | Post NMDA receptor activation events |
| KEGG:04530 | 0.0237566589162 | 0.5 | TUBA1A TUBA1B | Tight junction |
| REAC:R-HSA-1445148 | 0.0239057396727 | 0.5 | TUBA1A TUBA1B | Translocation of SLC2A4 (GLUT4) to the plasma membrane |
| HPA:0570743 | 0.0278463772546 | 0.75 | DNAJA1 TUBA1A TUBA1B | testis; cells in seminiferous ducts[High] |
| REAC:R-HSA-9663891 | 0.0282617295192 | 0.5 | TUBA1A TUBA1B | Selective autophagy |
| REAC:R-HSA-8852276 | 0.0290229039331 | 0.5 | TUBA1A TUBA1B | The role of GTSE1 in G2/M progression after G2 checkpoint |
| HPA:0461453 | 0.0292462264975 | 0.5 | TUBA1A TUBA1B | skin 1; hair follicles[High] |
| REAC:R-HSA-442755 | 0.0321680026233 | 0.5 | TUBA1A TUBA1B | Activation of NMDA receptors and postsynaptic events |
| KEGG:04814 | 0.0322340970049 | 0.5 | TUBA1A TUBA1B | Motor proteins |
| HPA:0471493 | 0.0323185629783 | 0.5 | TUBA1A TUBA1B | skin 2; vascular mural cells[High] |
| HPA:0471401 | 0.0328453637696 | 0.5 | TUBA1A TUBA1B | skin 2; cells in corneal layer[>=Low] |
| KEGG:05130 | 0.0334335704012 | 0.5 | TUBA1A TUBA1B | Pathogenic Escherichia coli infection |
| REAC:R-HSA-390466 | 0.0363250695065 | 0.5 | TUBA1A TUBA1B | Chaperonin-mediated protein folding |
| HPA:0461493 | 0.0366507731727 | 0.5 | TUBA1A TUBA1B | skin 1; vascular mural cells[High] |
| REAC:R-HSA-380320 | 0.0407325822829 | 0.5 | TUBA1A TUBA1B | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-391251 | 0.0425656343513 | 0.5 | TUBA1A TUBA1B | Protein folding |
| REAC:R-HSA-6811434 | 0.0434971593242 | 0.5 | TUBA1A TUBA1B | COPI-dependent Golgi-to-ER retrograde traffic |
| HPA:0130243 | 0.0447503600593 | 0.75 | DNAJA1 TUBA1A TUBA1B | colon; peripheral nerve/ganglion[High] |
| REAC:R-HSA-6807878 | 0.046351696636 | 0.5 | TUBA1A TUBA1B | COPI-mediated anterograde transport |
| CORUM:3008 | 0.049938562206 | 0.25 | TUBA1A | 60S APC containing complex |
| CORUM:6714 | 0.049938562206 | 0.25 | TUBA1A | TBCE-TBCB-tubulin(alpha) complex |
| CORUM:6881 | 0.049938562206 | 0.25 | EXT1 | EXT1-EXT2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DNAJA1 | TUBA1B | 0.993 |
mutually_exclusive (P68366)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | |
| DNAJA1 | TUBA1A | 0.968 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | ||
| EXT1 | TUBA1A | 0.968 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| TUBA1A | TUBA1B | 0.967 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM | ||
| EXT1 | DNAJA1 | 0.027 | 0.092 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| EXT1 | TUBA1B | 0.025 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes