hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02733.1
Complex Portal: CPX-13148
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAP3K2 | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | 5 | UniProt NCBI |
| MAP2K5 | Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) | 5 | UniProt NCBI |
| MAPK7 | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04540 | 2.98572877594e-06 | 1.0 | MAP3K2 MAP2K5 MAPK7 | Gap junction |
| REAC:R-HSA-198765 | 6.81845708859e-06 | 0.666666666667 | MAPK7 MAP2K5 | Signalling to ERK5 |
| WP:WP3915 | 1.86398464173e-05 | 1.0 | MAP3K2 MAP2K5 MAPK7 | Angiopoietin like protein 8 regulatory pathway |
| WP:WP2380 | 2.34580185085e-05 | 1.0 | MAP3K2 MAP2K5 MAPK7 | Brain derived neurotrophic factor BDNF signaling pathway |
| WP:WP481 | 3.69900149365e-05 | 1.0 | MAP3K2 MAP2K5 MAPK7 | Insulin signaling |
| WP:WP437 | 3.77770365309e-05 | 1.0 | MAP3K2 MAP2K5 MAPK7 | EGF EGFR signaling pathway |
| WP:WP382 | 0.000103352299006 | 1.0 | MAP3K2 MAP2K5 MAPK7 | MAPK signaling pathway |
| KEGG:04010 | 0.000123391020622 | 1.0 | MAP3K2 MAP2K5 MAPK7 | MAPK signaling pathway |
| WP:WP5087 | 0.000659719901928 | 1.0 | MAP3K2 MAP2K5 MAPK7 | Pleural mesothelioma |
| WP:WP2795 | 0.000973512535349 | 0.666666666667 | MAPK7 MAP2K5 | Cardiac hypertrophic response |
| KEGG:04912 | 0.00173372250929 | 0.666666666667 | MAP3K2 MAPK7 | GnRH signaling pathway |
| WP:WP1544 | 0.0026492939041 | 0.666666666667 | MAPK7 MAP2K5 | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04722 | 0.00376179101737 | 0.666666666667 | MAPK7 MAP2K5 | Neurotrophin signaling pathway |
| WP:WP185 | 0.0039339723602 | 0.666666666667 | MAPK7 MAP2K5 | Integrin mediated cell adhesion |
| KEGG:05418 | 0.00515305589505 | 0.666666666667 | MAPK7 MAP2K5 | Fluid shear stress and atherosclerosis |
| KEGG:04921 | 0.00524166128176 | 0.666666666667 | MAPK7 MAP2K5 | Oxytocin signaling pathway |
| WP:WP3931 | 0.00558201247738 | 0.666666666667 | MAPK7 MAP2K5 | Embryonic stem cell pluripotency pathways |
| GO:0071499 | 0.0140440992017 | 0.666666666667 | MAPK7 MAP2K5 | cellular response to laminar fluid shear stress |
| GO:0034616 | 0.0210651876021 | 0.666666666667 | MAPK7 MAP2K5 | response to laminar fluid shear stress |
| REAC:R-HSA-187037 | 0.0316091445651 | 0.666666666667 | MAPK7 MAP2K5 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-166520 | 0.0436932800731 | 0.666666666667 | MAPK7 MAP2K5 | Signaling by NTRKs |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAP2K5 | MAPK7 | 0.996 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MAP3K2 | MAP2K5 | 0.995 | 0.192 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MAP3K2 | MAPK7 | 0.487 | 0.12 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| MAP3K2 | huMAP3_02733.1 huMAP3_03708.1 huMAP3_08523.1 huMAP3_10808.1 huMAP3_10861.1 huMAP3_12897.1 |
| MAP2K5 | huMAP3_02733.1 huMAP3_03261.1 huMAP3_03708.1 huMAP3_10808.1 huMAP3_10861.1 |
| MAPK7 | huMAP3_02733.1 huMAP3_03261.1 huMAP3_10861.1 |