hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02750.1
Complex Portal: CPX-24033
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| STK40 | Serine/threonine-protein kinase 40 (EC 2.7.11.1) (SINK-homologous serine/threonine-protein kinase) (Sugen kinase 495) (SgK495) | 5 | UniProt NCBI |
| ETV5 | ETS translocation variant 5 (Ets-related protein ERM) | 5 | UniProt NCBI |
| DET1 | DET1 homolog (De-etiolated-1 homolog) | 5 | UniProt NCBI |
| ETV1 | ETS translocation variant 1 (Ets-related protein 81) | 5 | UniProt NCBI |
| TRIB2 | Tribbles homolog 2 (TRB-2) | 5 | UniProt NCBI |
| COP1 | E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2) | 5 | UniProt NCBI |
| TRIB1 | Tribbles homolog 1 (TRB-1) (G-protein-coupled receptor-induced gene 2 protein) (GIG-2) (SKIP1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1214 | 0.000205125012531 | 0.285714285714 | DET1 COP1 | Ubiquitin E3 ligase (DET1, DDB1, CUL4A, RBX1, COP1) |
| GO:0032436 | 0.000835286748042 | 0.571428571429 | TRIB1 DET1 COP1 TRIB2 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO:2000060 | 0.00175371310235 | 0.571428571429 | TRIB1 DET1 COP1 TRIB2 | positive regulation of ubiquitin-dependent protein catabolic process |
| GO:1901800 | 0.0023201010514 | 0.571428571429 | TRIB1 DET1 COP1 TRIB2 | positive regulation of proteasomal protein catabolic process |
| GO:1903052 | 0.00432969529852 | 0.571428571429 | TRIB1 DET1 COP1 TRIB2 | positive regulation of proteolysis involved in protein catabolic process |
| GO:0032434 | 0.0048515986555 | 0.571428571429 | TRIB1 DET1 COP1 TRIB2 | regulation of proteasomal ubiquitin-dependent protein catabolic process |
| GO:2000058 | 0.011574920454 | 0.571428571429 | TRIB1 DET1 COP1 TRIB2 | regulation of ubiquitin-dependent protein catabolic process |
| GO:0061136 | 0.0197221628961 | 0.571428571429 | TRIB1 DET1 COP1 TRIB2 | regulation of proteasomal protein catabolic process |
| GO:0045732 | 0.0224390732175 | 0.571428571429 | TRIB1 DET1 COP1 TRIB2 | positive regulation of protein catabolic process |
| GO:1903050 | 0.0386866758686 | 0.571428571429 | TRIB1 DET1 COP1 TRIB2 | regulation of proteolysis involved in protein catabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| COP1 | TRIB1 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DET1 | TRIB1 | 1.0 |
structurally_consistent (Q92519)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK40 | DET1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| DET1 | COP1 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ETV5 | COP1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ETV1 | COP1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| STK40 | TRIB1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TRIB2 | TRIB1 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| DET1 | TRIB2 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TRIB2 | COP1 | 0.998 |
structurally_consistent (Q96RU8)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| STK40 | TRIB2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| STK40 | ETV5 | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ETV5 | DET1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| STK40 | ETV1 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| STK40 | COP1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| DET1 | ETV1 | 0.988 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ETV5 | ETV1 | 0.902 | bioplex3_WMM WMM_only | ||
| ETV1 | TRIB1 | 0.418 | bioplex3_WMM WMM_only | ||
| ETV5 | TRIB1 | 0.418 | bioplex3_WMM WMM_only |
Related Complexes