hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_02751.1
Complex Portal: CPX-22565
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VLDLR | Very low-density lipoprotein receptor (VLDL receptor) (VLDL-R) | 5 | UniProt NCBI |
| LRPAP1 | Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) | 5 | UniProt NCBI |
| LRP2 | Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin) | 5 | UniProt NCBI |
| LRP8 | Low-density lipoprotein receptor-related protein 8 (LRP-8) (Apolipoprotein E receptor 2) | 5 | UniProt NCBI |
| LRP1 | Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005041 | 1.31622611039e-07 | 0.8 | VLDLR LRP1 LRP2 LRP8 | low-density lipoprotein particle receptor activity |
| GO:0030228 | 2.39287617466e-07 | 0.8 | VLDLR LRP1 LRP2 LRP8 | lipoprotein particle receptor activity |
| KEGG:04979 | 9.90919093578e-06 | 0.6 | LRP1 LRPAP1 LRP2 | Cholesterol metabolism |
| GO:0038024 | 1.78207144985e-05 | 0.8 | VLDLR LRP1 LRP2 LRP8 | cargo receptor activity |
| REAC:R-HSA-975634 | 3.07163147334e-05 | 0.6 | LRP8 LRP2 LRP1 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 3.83555767792e-05 | 0.6 | LRP8 LRP2 LRP1 | Metabolism of fat-soluble vitamins |
| GO:0034185 | 0.000211268761872 | 0.6 | VLDLR LRP1 LRP8 | apolipoprotein binding |
| REAC:R-HSA-2187338 | 0.000235592298974 | 0.6 | LRP8 LRP2 LRP1 | Visual phototransduction |
| WP:WP5110 | 0.00032310719867 | 0.4 | VLDLR LRP1 | Familial hyperlipidemia type 3 |
| GO:0045056 | 0.000436807598019 | 0.6 | LRP1 LRPAP1 LRP2 | transcytosis |
| GO:0006897 | 0.00144724421431 | 1.0 | LRP8 VLDLR LRP1 LRPAP1 LRP2 | endocytosis |
| REAC:R-HSA-196854 | 0.00194346431817 | 0.6 | LRP8 LRP2 LRP1 | Metabolism of vitamins and cofactors |
| REAC:R-HSA-9709957 | 0.00451677062682 | 0.6 | LRP8 LRP2 LRP1 | Sensory Perception |
| GO:0038025 | 0.00468200720083 | 0.4 | VLDLR LRP8 | reelin receptor activity |
| GO:0097242 | 0.00475337188383 | 0.6 | LRP1 LRPAP1 LRP2 | amyloid-beta clearance |
| GO:0098657 | 0.00559566605185 | 1.0 | LRP8 VLDLR LRP1 LRPAP1 LRP2 | import into cell |
| GO:0006898 | 0.00685002760202 | 0.8 | VLDLR LRP1 LRPAP1 LRP2 | receptor-mediated endocytosis |
| WP:WP5304 | 0.010677250915 | 0.4 | LRP1 LRPAP1 | Cholesterol metabolism |
| GO:0030229 | 0.0140440992017 | 0.4 | VLDLR LRP8 | very-low-density lipoprotein particle receptor activity |
| GO:1905167 | 0.0140440992017 | 0.4 | LRP1 LRP2 | positive regulation of lysosomal protein catabolic process |
| GO:0001523 | 0.0279690439474 | 0.6 | LRP8 LRP2 LRP1 | retinoid metabolic process |
| GO:0038026 | 0.0280843539964 | 0.4 | VLDLR LRP8 | reelin-mediated signaling pathway |
| GO:0016101 | 0.0310683011928 | 0.6 | LRP8 LRP2 LRP1 | diterpenoid metabolic process |
| GO:0043235 | 0.0329457298686 | 0.8 | VLDLR LRP1 LRP2 LRP8 | receptor complex |
| GO:0006721 | 0.0457443058639 | 0.6 | LRP8 LRP2 LRP1 | terpenoid metabolic process |
| GO:1904352 | 0.0468008499735 | 0.4 | LRP1 LRP2 | positive regulation of protein catabolic process in the vacuole |
| CORUM:7535 | 0.0498708842806 | 0.2 | LRP1 | CD44-LRP1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LRP2 | LRPAP1 | 0.99 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRP8 | LRPAP1 | 0.979 | 0.058 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| VLDLR | LRPAP1 | 0.966 | 0.088 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| LRPAP1 | LRP1 | 0.96 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| LRP2 | LRP1 | 0.575 | 0.254 | bioplex_WMM bioplex3_WMM WMM_only | |
| VLDLR | LRP2 | 0.497 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP8 | VLDLR | 0.172 | 0.082 |
mutually_exclusive (P30533)
|
bioplex_WMM bioplex3_WMM WMM_only |
| VLDLR | LRP1 | 0.117 | 0.166 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP8 | LRP1 | 0.111 | 0.152 | bioplex_WMM bioplex3_WMM WMM_only | |
| LRP8 | LRP2 | 0.066 | 0.086 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes