hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02774.1
Complex Portal: CPX-14861
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PROC | Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide] | 5 | UniProt NCBI |
| PROS1 | Vitamin K-dependent protein S | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001038 | 3.41752350426e-06 | 1.0 | PROS1 PROC | Warfarin-induced skin necrosis |
| HP:0002638 | 1.02525705128e-05 | 1.0 | PROS1 PROC | Superficial thrombophlebitis |
| WP:WP5186 | 2.8092043205e-05 | 1.0 | PROS1 PROC | Vitamin K metabolism and activation of dependent proteins |
| REAC:R-HSA-159763 | 4.78453290596e-05 | 1.0 | PROS1 PROC | Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus |
| REAC:R-HSA-159740 | 6.15154230766e-05 | 1.0 | PROS1 PROC | Gamma-carboxylation of protein precursors |
| REAC:R-HSA-159782 | 6.15154230766e-05 | 1.0 | PROS1 PROC | Removal of aminoterminal propeptides from gamma-carboxylated proteins |
| HP:0005305 | 7.17679935894e-05 | 1.0 | PROS1 PROC | Cerebral venous thrombosis |
| REAC:R-HSA-159854 | 7.68942788458e-05 | 1.0 | PROS1 PROC | Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| HP:0004418 | 0.000153788557692 | 1.0 | PROS1 PROC | Thrombophlebitis |
| HP:0030780 | 0.000225556551281 | 1.0 | PROS1 PROC | Abnormality of the protein C anticoagulant pathway |
| REAC:R-HSA-140875 | 0.00023239159829 | 1.0 | PROS1 PROC | Common Pathway of Fibrin Clot Formation |
| HP:0100724 | 0.000266566833332 | 1.0 | PROS1 PROC | Hypercoagulability |
| REAC:R-HSA-140837 | 0.000324664732905 | 1.0 | PROS1 PROC | Intrinsic Pathway of Fibrin Clot Formation |
| KEGG:04610 | 0.000403985690766 | 1.0 | PROS1 PROC | Complement and coagulation cascades |
| HP:0002625 | 0.000410102820511 | 1.0 | PROS1 PROC | Deep venous thrombosis |
| WP:WP558 | 0.000460113616736 | 1.0 | PROS1 PROC | Complement and coagulation cascades |
| REAC:R-HSA-140877 | 0.00079457421474 | 1.0 | PROS1 PROC | Formation of Fibrin Clot (Clotting Cascade) |
| REAC:R-HSA-163841 | 0.00113803532692 | 1.0 | PROS1 PROC | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation |
| HP:0002204 | 0.00169509165811 | 1.0 | PROS1 PROC | Pulmonary embolism |
| HP:0005293 | 0.00191723068589 | 1.0 | PROS1 PROC | Venous insufficiency |
| HP:0100758 | 0.0036943429081 | 1.0 | PROS1 PROC | Gangrene |
| HP:0004936 | 0.00688972738458 | 1.0 | PROS1 PROC | Venous thrombosis |
| REAC:R-HSA-202733 | 0.00880183178522 | 1.0 | PROS1 PROC | Cell surface interactions at the vascular wall |
| HP:0000963 | 0.0110727761538 | 1.0 | PROS1 PROC | Thin skin |
| HP:0000979 | 0.0190185183012 | 1.0 | PROS1 PROC | Purpura |
| HP:0003256 | 0.0252247409849 | 1.0 | PROS1 PROC | Abnormality of the coagulation cascade |
| HP:0002624 | 0.0277776310426 | 1.0 | PROS1 PROC | Abnormal venous morphology |
| HP:0030875 | 0.0423875440233 | 1.0 | PROS1 PROC | Abnormality of pulmonary circulation |
| HP:0001977 | 0.0451215628267 | 1.0 | PROS1 PROC | Abnormal thrombosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PROC | PROS1 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| PROC | huMAP3_02774.1 huMAP3_12681.1 huMAP3_12792.1 huMAP3_13191.1 |
| PROS1 | huMAP3_02774.1 huMAP3_12928.1 |