hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02779.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| COL4A5 | Collagen alpha-5(IV) chain | 5 | UniProt NCBI |
| COL17A1 | Collagen alpha-1(XVII) chain (180 kDa bullous pemphigoid antigen 2) (Bullous pemphigoid antigen 2) [Cleaved into: 120 kDa linear IgA disease antigen (120 kDa linear IgA dermatosis antigen) (Linear IgA disease antigen 1) (LAD-1); 97 kDa linear IgA disease antigen (97 kDa linear IgA bullous dermatosis antigen) (97 kDa LAD antigen) (97-LAD) (Linear IgA bullous disease antigen of 97 kDa) (LABD97)] | 5 | UniProt NCBI |
| COL4A1 | Collagen alpha-1(IV) chain [Cleaved into: Arresten] | 5 | UniProt NCBI |
| COL4A4 | Collagen alpha-4(IV) chain | 5 | UniProt NCBI |
| COL6A3 | Collagen alpha-3(VI) chain | 5 | UniProt NCBI |
| LAIR2 | Leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) (CD antigen CD306) | 4 | UniProt NCBI |
| CCBE1 | Collagen and calcium-binding EGF domain-containing protein 1 (Full of fluid protein homolog) | 5 | UniProt NCBI |
| COL26A1 | Collagen alpha-1(XXVI) chain (Alpha-1 type XXVI collagen) (EMI domain-containing protein 2) (Emilin and multimerin domain-containing protein 2) (Emu2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8948216 | 3.96532736613e-08 | 0.666666666667 | COL17A1 COL26A1 COL4A1 COL4A4 | Collagen chain trimerization |
| REAC:R-HSA-1442490 | 3.05932552684e-07 | 0.666666666667 | COL17A1 COL26A1 COL4A1 COL4A4 | Collagen degradation |
| KEGG:04974 | 3.50709282732e-07 | 0.666666666667 | COL17A1 COL26A1 COL4A1 COL4A4 | Protein digestion and absorption |
| REAC:R-HSA-1650814 | 3.90777239142e-07 | 0.666666666667 | COL17A1 COL26A1 COL4A1 COL4A4 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 1.48174523696e-06 | 0.666666666667 | COL17A1 COL26A1 COL4A1 COL4A4 | Collagen formation |
| REAC:R-HSA-1474228 | 6.85992153937e-06 | 0.666666666667 | COL17A1 COL26A1 COL4A1 COL4A4 | Degradation of the extracellular matrix |
| REAC:R-HSA-2022090 | 0.000113827315454 | 0.5 | COL17A1 COL4A1 COL4A4 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1474244 | 0.000155242509846 | 0.666666666667 | COL17A1 COL26A1 COL4A1 COL4A4 | Extracellular matrix organization |
| REAC:R-HSA-2214320 | 0.00200991204249 | 0.333333333333 | COL4A4 COL4A1 | Anchoring fibril formation |
| GO:0030312 | 0.00293512623989 | 0.833333333333 | COL17A1 CCBE1 COL4A1 COL26A1 COL4A4 | external encapsulating structure |
| GO:0031012 | 0.00293512623989 | 0.833333333333 | COL17A1 CCBE1 COL4A1 COL26A1 COL4A4 | extracellular matrix |
| REAC:R-HSA-2243919 | 0.00309047926945 | 0.333333333333 | COL4A4 COL4A1 | Crosslinking of collagen fibrils |
| GO:0030020 | 0.00699636827123 | 0.5 | COL17A1 COL4A1 COL4A4 | extracellular matrix structural constituent conferring tensile strength |
| REAC:R-HSA-3000157 | 0.00902151290218 | 0.333333333333 | COL4A4 COL4A1 | Laminin interactions |
| REAC:R-HSA-419037 | 0.00902151290218 | 0.333333333333 | COL4A4 COL4A1 | NCAM1 interactions |
| KEGG:04512 | 0.0158846761267 | 0.333333333333 | COL4A4 COL4A1 | ECM-receptor interaction |
| REAC:R-HSA-375165 | 0.0220691409046 | 0.333333333333 | COL4A4 COL4A1 | NCAM signaling for neurite out-growth |
| KEGG:05222 | 0.0261678409889 | 0.333333333333 | COL4A4 COL4A1 | Small cell lung cancer |
| KEGG:05146 | 0.0261678409889 | 0.333333333333 | COL4A4 COL4A1 | Amoebiasis |
| KEGG:04933 | 0.0267786555833 | 0.333333333333 | COL4A4 COL4A1 | AGE-RAGE signaling pathway in diabetic complications |
| REAC:R-HSA-3000171 | 0.0288812004442 | 0.333333333333 | COL4A4 COL4A1 | Non-integrin membrane-ECM interactions |
| REAC:R-HSA-186797 | 0.0288812004442 | 0.333333333333 | COL4A4 COL4A1 | Signaling by PDGF |
| WP:WP4658 | 0.0388355255908 | 0.333333333333 | COL4A4 COL4A1 | Small cell lung cancer |
| KEGG:04926 | 0.0412011786405 | 0.333333333333 | COL4A4 COL4A1 | Relaxin signaling pathway |
| REAC:R-HSA-3000178 | 0.0422459670228 | 0.333333333333 | COL4A4 COL4A1 | ECM proteoglycans |
| REAC:R-HSA-216083 | 0.0498675109087 | 0.333333333333 | COL4A4 COL4A1 | Integrin cell surface interactions |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LAIR2 | COL4A1 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| COL4A4 | LAIR2 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LAIR2 | COL4A5 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| COL6A3 | LAIR2 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| COL17A1 | LAIR2 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LAIR2 | CCBE1 | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| COL4A5 | COL4A1 | 0.98 | bioplex_WMM bioplex3_WMM WMM_only | |
| LAIR2 | COL26A1 | 0.969 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| COL6A3 | COL4A1 | 0.904 | 0.626 | bioplex3_WMM WMM_only |
| COL17A1 | COL4A1 | 0.904 | bioplex3_WMM WMM_only | |
| COL17A1 | COL4A5 | 0.902 | bioplex3_WMM WMM_only | |
| COL17A1 | COL6A3 | 0.902 | bioplex3_WMM WMM_only | |
| COL6A3 | COL4A5 | 0.902 | bioplex3_WMM WMM_only | |
| COL4A4 | COL6A3 | 0.902 | bioplex3_WMM WMM_only | |
| COL17A1 | COL4A4 | 0.902 | bioplex3_WMM WMM_only | |
| COL4A4 | COL4A1 | 0.796 | bioplex3_WMM WMM_only | |
| COL4A4 | COL4A5 | 0.656 | bioplex3_WMM WMM_only | |
| COL4A4 | CCBE1 | 0.415 | bioplex3_WMM WMM_only | |
| COL4A4 | COL26A1 | 0.415 | bioplex3_WMM WMM_only | |
| CCBE1 | COL26A1 | 0.415 | bioplex3_WMM WMM_only | |
| COL17A1 | COL26A1 | 0.214 | bioplex3_WMM WMM_only | |
| COL6A3 | CCBE1 | 0.214 | bioplex3_WMM WMM_only | |
| COL6A3 | COL26A1 | 0.214 | bioplex3_WMM WMM_only | |
| COL17A1 | CCBE1 | 0.214 | bioplex3_WMM WMM_only | |
| CCBE1 | COL4A5 | 0.131 | bioplex3_WMM WMM_only | |
| CCBE1 | COL4A1 | 0.113 | bioplex3_WMM WMM_only | |
| COL26A1 | COL4A5 | 0.106 | bioplex3_WMM WMM_only | |
| COL26A1 | COL4A1 | 0.078 | bioplex3_WMM WMM_only |
Related Complexes