hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02792.1
Complex Portal: CPX-18928
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| VPS18 | Vacuolar protein sorting-associated protein 18 homolog (hVPS18) | 5 | UniProt NCBI |
| VPS16 | Vacuolar protein sorting-associated protein 16 homolog (hVPS16) | 5 | UniProt NCBI |
| TECPR2 | Tectonin beta-propeller repeat-containing protein 2 (WD repeat-containing protein KIAA0329/KIAA0297) | 5 | UniProt NCBI |
| VPS41 | Vacuolar protein sorting-associated protein 41 homolog (S53) | 5 | UniProt NCBI |
| VPS33A | Vacuolar protein sorting-associated protein 33A (hVPS33A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6389 | 1.91772524101e-12 | 0.8 | VPS18 VPS41 VPS33A VPS16 | HOPS complex |
| REAC:R-HSA-9754560 | 5.38065562428e-11 | 0.8 | VPS18 VPS41 VPS33A VPS16 | SARS-CoV-2 modulates autophagy |
| CORUM:6388 | 2.80175822576e-08 | 0.6 | VPS18 VPS33A VPS16 | CORVET complex |
| GO:0034058 | 4.33992010508e-08 | 0.8 | VPS18 VPS41 VPS33A VPS16 | endosomal vesicle fusion |
| GO:0030897 | 6.50952358374e-08 | 0.8 | VPS18 VPS41 VPS33A VPS16 | HOPS complex |
| GO:0035542 | 6.50952358374e-08 | 0.8 | VPS18 VPS41 VPS33A VPS16 | regulation of SNARE complex assembly |
| GO:0035493 | 4.02274655956e-07 | 0.8 | VPS18 VPS41 VPS33A VPS16 | SNARE complex assembly |
| WP:WP4217 | 1.17619043283e-06 | 0.8 | VPS18 VPS41 VPS33A VPS16 | Ebola virus infection in host |
| KEGG:04148 | 1.19040546073e-06 | 0.8 | VPS18 VPS41 VPS33A VPS16 | Efferocytosis |
| KEGG:04140 | 3.00693972585e-06 | 0.8 | VPS18 VPS41 VPS33A VPS16 | Autophagy - animal |
| WP:WP5115 | 5.6319867132e-06 | 0.8 | VPS18 VPS41 VPS33A VPS16 | Network map of SARS CoV 2 signaling pathway |
| KEGG:05132 | 1.28860790264e-05 | 0.8 | VPS18 VPS41 VPS33A VPS16 | Salmonella infection |
| CORUM:944 | 1.36501667663e-05 | 0.4 | VPS18 VPS16 | Class C Vps complex (VPS11, VPS18, VPS16) |
| GO:0033263 | 1.92180881975e-05 | 0.6 | VPS18 VPS33A VPS16 | CORVET complex |
| REAC:R-HSA-9705683 | 2.13137033678e-05 | 0.8 | VPS18 VPS41 VPS33A VPS16 | SARS-CoV-2-host interactions |
| GO:0008333 | 4.81842507515e-05 | 0.8 | VPS18 VPS41 VPS33A VPS16 | endosome to lysosome transport |
| GO:0099023 | 6.84426164966e-05 | 0.8 | VPS18 VPS41 VPS33A VPS16 | vesicle tethering complex |
| REAC:R-HSA-9694516 | 9.5278034922e-05 | 0.8 | VPS18 VPS41 VPS33A VPS16 | SARS-CoV-2 Infection |
| CORUM:2573 | 0.000136445626745 | 0.4 | VPS18 VPS16 | Class C VPS/HOPS complex |
| GO:0006906 | 0.000334585912591 | 0.8 | VPS18 VPS41 VPS33A VPS16 | vesicle fusion |
| REAC:R-HSA-9679506 | 0.000342953102259 | 0.8 | VPS18 VPS41 VPS33A VPS16 | SARS-CoV Infections |
| GO:0090174 | 0.000365836607157 | 0.8 | VPS18 VPS41 VPS33A VPS16 | organelle membrane fusion |
| GO:0007041 | 0.000649914918254 | 0.8 | VPS18 VPS41 VPS33A VPS16 | lysosomal transport |
| WP:WP4936 | 0.000798299856649 | 0.4 | VPS18 VPS33A | Perturbations to host cell autophagy induced by SARS CoV 2 proteins |
| GO:0048284 | 0.00114810449155 | 0.8 | VPS18 VPS41 VPS33A VPS16 | organelle fusion |
| GO:0061025 | 0.00143851496917 | 0.8 | VPS18 VPS41 VPS33A VPS16 | membrane fusion |
| GO:0007034 | 0.00157850838896 | 0.8 | VPS18 VPS41 VPS33A VPS16 | vacuolar transport |
| REAC:R-HSA-9824446 | 0.00414507922686 | 0.8 | VPS18 VPS41 VPS33A VPS16 | Viral Infection Pathways |
| GO:0005770 | 0.00858929342321 | 0.8 | VPS18 VPS41 VPS33A VPS16 | late endosome |
| REAC:R-HSA-5663205 | 0.00938555933211 | 0.8 | VPS18 VPS41 VPS33A VPS16 | Infectious disease |
| HP:0002453 | 0.00979150178217 | 0.4 | VPS16 VPS41 | Abnormal globus pallidus morphology |
| HP:0012444 | 0.0163336632741 | 0.8 | VPS16 VPS41 VPS33A TECPR2 | Brain atrophy |
| HP:0007367 | 0.0243275767135 | 0.8 | VPS16 VPS41 VPS33A TECPR2 | Atrophy/Degeneration affecting the central nervous system |
| GO:0016050 | 0.0329457298686 | 0.8 | VPS18 VPS41 VPS33A VPS16 | vesicle organization |
| GO:0043254 | 0.0368664091126 | 0.8 | VPS18 VPS41 VPS33A VPS16 | regulation of protein-containing complex assembly |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| VPS18 | VPS41 | 1.0 | 0.316 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| VPS16 | VPS41 | 1.0 | 0.408 |
structurally_consistent (Q9P253)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| VPS16 | VPS33A | 1.0 | 0.962 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () |
| VPS41 | VPS33A | 1.0 | 0.46 |
mutually_exclusive (Q9H269)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| VPS18 | VPS16 | 0.999 | 0.94 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM hein () |
| TECPR2 | VPS41 | 0.999 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VPS16 | TECPR2 | 0.998 | 0.158 |
mutually_exclusive (Q96AX1)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| VPS18 | VPS33A | 0.998 | 0.768 | hein_WMM bioplex_WMM bioplex3_WMM hein () fraction | |
| VPS18 | TECPR2 | 0.998 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TECPR2 | VPS33A | 0.964 | 0.172 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
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