hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02807.1
Complex Portal: CPX-12961
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TLR6 | Toll-like receptor 6 (CD antigen CD286) | 5 | UniProt NCBI |
| TLR1 | Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3877 | 4.4691886917e-05 | 1.0 | TLR6 TLR1 | MYD88 distinct input output pathway |
| WP:WP3858 | 0.000149398593408 | 1.0 | TLR6 TLR1 | Toll like receptor signaling related to MyD88 |
| REAC:R-HSA-5603041 | 0.000155497319444 | 1.0 | TLR6 TLR1 | IRAK4 deficiency (TLR2/4) |
| REAC:R-HSA-5602498 | 0.000155497319444 | 1.0 | TLR6 TLR1 | MyD88 deficiency (TLR2/4) |
| REAC:R-HSA-5686938 | 0.000179419983974 | 1.0 | TLR6 TLR1 | Regulation of TLR by endogenous ligand |
| REAC:R-HSA-5602358 | 0.000599775374997 | 1.0 | TLR6 TLR1 | Diseases associated with the TLR signaling cascade |
| REAC:R-HSA-5260271 | 0.000599775374997 | 1.0 | TLR6 TLR1 | Diseases of Immune System |
| KEGG:04620 | 0.000608173227025 | 1.0 | TLR6 TLR1 | Toll-like receptor signaling pathway |
| GO:0070340 | 0.00140460216025 | 1.0 | TLR6 TLR1 | detection of bacterial lipopeptide |
| WP:WP75 | 0.00144844277313 | 1.0 | TLR6 TLR1 | Toll like receptor signaling pathway |
| KEGG:05152 | 0.001720800216 | 1.0 | TLR6 TLR1 | Tuberculosis |
| GO:0035663 | 0.0028092043205 | 1.0 | TLR6 TLR1 | Toll-like receptor 2 binding |
| GO:0042494 | 0.0028092043205 | 1.0 | TLR6 TLR1 | detection of bacterial lipoprotein |
| REAC:R-HSA-1236974 | 0.0061002794551 | 1.0 | TLR6 TLR1 | ER-Phagosome pathway |
| REAC:R-HSA-166058 | 0.00762962122326 | 1.0 | TLR6 TLR1 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168188 | 0.00762962122326 | 1.0 | TLR6 TLR1 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.00795599471791 | 1.0 | TLR6 TLR1 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 0.00795599471791 | 1.0 | TLR6 TLR1 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-1236975 | 0.00812174460787 | 1.0 | TLR6 TLR1 | Antigen processing-Cross presentation |
| GO:0071221 | 0.00983221512175 | 1.0 | TLR6 TLR1 | cellular response to bacterial lipopeptide |
| GO:0071220 | 0.00983221512175 | 1.0 | TLR6 TLR1 | cellular response to bacterial lipoprotein |
| GO:0070339 | 0.00983221512175 | 1.0 | TLR6 TLR1 | response to bacterial lipopeptide |
| GO:0071723 | 0.00983221512175 | 1.0 | TLR6 TLR1 | lipopeptide binding |
| REAC:R-HSA-166016 | 0.0128208394262 | 1.0 | TLR6 TLR1 | Toll Like Receptor 4 (TLR4) Cascade |
| GO:0032493 | 0.0131096201623 | 1.0 | TLR6 TLR1 | response to bacterial lipoprotein |
| GO:0032490 | 0.0131096201623 | 1.0 | TLR6 TLR1 | detection of molecule of bacterial origin |
| GO:0098543 | 0.016855225923 | 1.0 | TLR6 TLR1 | detection of other organism |
| GO:0016045 | 0.016855225923 | 1.0 | TLR6 TLR1 | detection of bacterium |
| REAC:R-HSA-168898 | 0.0171064139006 | 1.0 | TLR6 TLR1 | Toll-like Receptor Cascades |
| GO:0034135 | 0.0210690324038 | 1.0 | TLR6 TLR1 | regulation of toll-like receptor 2 signaling pathway |
| GO:0035325 | 0.0257510396046 | 1.0 | TLR6 TLR1 | Toll-like receptor binding |
| GO:0098581 | 0.0365196561665 | 1.0 | TLR6 TLR1 | detection of external biotic stimulus |
| GO:0034134 | 0.0426062655276 | 1.0 | TLR6 TLR1 | toll-like receptor 2 signaling pathway |
| CORUM:7048 | 0.0499419797295 | 0.5 | TLR1 | TLR1-TLR2 complex |
| CORUM:7049 | 0.0499419797295 | 0.5 | TLR1 | TLR1-TLR2-lipoprotein complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TLR6 | TLR1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes