hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_02811.1
Complex Portal: CPX-16402
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| C5 | Complement C5 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4) [Cleaved into: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain] | 5 | UniProt NCBI |
| MAB21L4 | Protein mab-21-like 4 | 2 | UniProt NCBI |
| TIGAR | Fructose-2,6-bisphosphatase TIGAR (EC 3.1.3.46) (TP53-induced glycolysis and apoptosis regulator) (TP53-induced glycolysis regulatory phosphatase) | 5 | UniProt NCBI |
| PYCARD | Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1) | 5 | UniProt NCBI |
| ANKRD22 | Ankyrin repeat domain-containing protein 22 | 2 | UniProt NCBI |
| C4BPA | C4b-binding protein alpha chain (C4bp) (Proline-rich protein) (PRP) | 5 | UniProt NCBI |
| PHF11 | PHD finger protein 11 (BRCA1 C-terminus-associated protein) (Renal carcinoma antigen NY-REN-34) | 5 | UniProt NCBI |
| ITIH1 | Inter-alpha-trypsin inhibitor heavy chain H1 (ITI heavy chain H1) (ITI-HC1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:05133 | 0.000112854967466 | 0.428571428571 | C5 C4BPA PYCARD | Pertussis |
| KEGG:04610 | 0.0251056026519 | 0.285714285714 | C5 C4BPA | Complement and coagulation cascades |
| REAC:R-HSA-977606 | 0.030972755234 | 0.285714285714 | C5 C4BPA | Regulation of Complement cascade |
| REAC:R-HSA-166658 | 0.0425383740248 | 0.285714285714 | C5 C4BPA | Complement cascade |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAB21L4 | PHF11 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| C5 | PHF11 | 0.998 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ITIH1 | PHF11 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| C4BPA | PHF11 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| TIGAR | PHF11 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ANKRD22 | PHF11 | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PYCARD | PHF11 | 0.992 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PYCARD | ANKRD22 | 0.901 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ITIH1 | C4BPA | 0.828 | 0.272 | bioplex3_WMM WMM_only | |
| MAB21L4 | ANKRD22 | 0.827 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MAB21L4 | PYCARD | 0.824 | bioplex_WMM bioplex3_WMM WMM_only treiber_WMM | ||
| C5 | ANKRD22 | 0.634 | bioplex3_WMM WMM_only | ||
| C4BPA | MAB21L4 | 0.634 | bioplex3_WMM WMM_only | ||
| ITIH1 | MAB21L4 | 0.634 | bioplex3_WMM WMM_only | ||
| C4BPA | ANKRD22 | 0.634 | bioplex3_WMM WMM_only | ||
| C5 | MAB21L4 | 0.633 | bioplex3_WMM WMM_only | ||
| TIGAR | ANKRD22 | 0.605 | bioplex3_WMM WMM_only | ||
| ITIH1 | ANKRD22 | 0.587 | bioplex3_WMM WMM_only | ||
| C5 | C4BPA | 0.534 | 0.236 | bioplex3_WMM WMM_only | |
| C5 | ITIH1 | 0.534 | 0.468 | bioplex3_WMM WMM_only | |
| TIGAR | MAB21L4 | 0.415 | bioplex3_WMM WMM_only | ||
| C5 | TIGAR | 0.384 | 0.054 | bioplex3_WMM WMM_only | |
| TIGAR | C4BPA | 0.373 | 0.04 | bioplex3_WMM WMM_only | |
| ITIH1 | TIGAR | 0.373 | 0.014 | bioplex3_WMM WMM_only | |
| C5 | PYCARD | 0.362 | 0.072 | bioplex3_WMM WMM_only | |
| C4BPA | PYCARD | 0.352 | 0.038 | bioplex3_WMM WMM_only | |
| ITIH1 | PYCARD | 0.352 | 0.052 | bioplex3_WMM WMM_only | |
| TIGAR | PYCARD | 0.274 | 0.0632 | bioplex3_WMM WMM_only |
Related Complexes